Complement Components (C1, C2, C3, C4) In Bronchial Secretions ...

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Abstract

Shortly after intranasal infection of guinea pigs with Mycoplasma pneumoniae, the titers of the complement components increased significantly in bronchial secretions by the folllowing amounts, compared with the titer of a control group: C1, about 2-fold; C2, 1.6-fold; C3, 17-fold; and C4, 942-fold. Histopathological signs of inflammation were not apparent at this time. At 2 weeks after infection, when the titers of complement components in the bronchial secretions were at the level of control values or lower, the serum antibody titer increased, and it reached the highest level at 6 weeks after infection. Therefore, one can distinguish two phases of reaction of the macroorganism to intranasal inoculation. The increase in complement components shortly after infection may represent an earlyunspecific defense mechanism of the host before the specific immune response becomes effective, since the complement system can be activated by M. pneumoniae via the classical as well as the alternative pathway in the absence of antibodies.

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• Surface modulation of classical pathway activation: C2 and C3 convertase formation and regulation on sheep, guinea pig, and human erythrocytes. Brown EJ, Ramsey J, Hammer CH, Frank MM. Brown EJ, et al. J Immunol. 1983 Jul;131(1):403-8. J Immunol. 1983. PMID: 6602833
• Interactions between mycoplasma pneumoniae and the first components of complement. Bredt W, Wellek B, Brunner H, Loos M. Bredt W, et al. Infect Immun. 1977 Jan;15(1):7-12. doi: 10.1128/iai.15.1.7-12.1977. Infect Immun. 1977. PMID: 832909 Free PMC article.
• Level of complement activity and components C1, C4, C2, and C3 in complement response to bacterial challenge in malnourished rats. Sakamoto M, Ishii S, Nishioka K, Shimada K. Sakamoto M, et al. Infect Immun. 1981 May;32(2):553-6. doi: 10.1128/iai.32.2.553-556.1981. Infect Immun. 1981. PMID: 7251136 Free PMC article.
• The properdin pathway: mechanisms of complement activation and analogies to the classical pathway. Fearon DT, Austen KF, Ruddy S. Fearon DT, et al. Rheumatology. 1975;6:2-16. Rheumatology. 1975. PMID: 1105744 Review. No abstract available.
• Activation of the complement system by antibody-antigen complexes: the classical pathway. Porter RR, Reid KB. Porter RR, et al. Adv Protein Chem. 1979;33:1-71. doi: 10.1016/s0065-3233(08)60458-1. Adv Protein Chem. 1979. PMID: 396780 Review. No abstract available.

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• Antibacterial Fusion Proteins Enhance Moraxella catarrhalis Killing. Laabei M, Colineau L, Bettoni S, Maziarz K, Ermert D, Riesbeck K, Ram S, Blom AM. Laabei M, et al. Front Immunol. 2020 Sep 2;11:2122. doi: 10.3389/fimmu.2020.02122. eCollection 2020. Front Immunol. 2020. PMID: 32983170 Free PMC article.
• Insights into the pathogenesis of Mycoplasma pneumoniae (Review). He J, Liu M, Ye Z, Tan T, Liu X, You X, Zeng Y, Wu Y. He J, et al. Mol Med Rep. 2016 Nov;14(5):4030-4036. doi: 10.3892/mmr.2016.5765. Epub 2016 Sep 23. Mol Med Rep. 2016. PMID: 27667580 Free PMC article. Review.
• Role of complement component C1q in phagocytosis of Listeria monocytogenes by murine macrophage-like cell lines. Alvarez-Dominguez C, Carrasco-Marin E, Leyva-Cobian F. Alvarez-Dominguez C, et al. Infect Immun. 1993 Sep;61(9):3664-72. doi: 10.1128/iai.61.9.3664-3672.1993. Infect Immun. 1993. PMID: 8359889 Free PMC article.
• Auto-antibody dependent activation of the autologous classical complement pathway by guinea-pig red cells treated with influenza virus or neuraminidase: in vitro and in vivo study. Lambre CR, Thibon M, Le Maho S, Di Bella G. Lambre CR, et al. Immunology. 1983 Jun;49(2):311-9. Immunology. 1983. PMID: 6852870 Free PMC article.

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• Administration, Intranasal Actions
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• Bronchi / immunology* Actions
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• Complement C1 / metabolism Actions
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