Top 14+ Cx-5461 hay nhất
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1.CX-5461 Activates The DNA Damage Response And Demonstrates ...
26 thg 5, 2020 · Here, we demonstrate CX-5461, the first-in-class inhibitor of RNA polymerase I transcription of ribosomal RNA genes (rDNA), induces replication ...
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2.CX-5461 Is A DNA G-quadruplex Stabilizer With Selective Lethality In ...
17 thg 2, 2017 · 18). CX-5461 is an rDNA transcription inhibitor currently in phase I trials for haematologic malignancies. CX-5461 reduces the binding affinity ...
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3.Pidnarulex (CX-5461) | Selleck | DNA/RNA Synthesis Inhibitor
CX-5461 possesses 250- to 300-fold selectivity for inhibition of rRNA transcription versus DNA replication and protein translation. CX-5461 exhibits broad ...
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4.Study Of CX-5461 In Patients With Solid Tumours And BRCA1/2 ...
18 thg 5, 2021 · CX-5461 (Pidnarulex), a synthetically-derived small molecule that selectively kills HR-deficient cancer cells through the binding and ...
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5.The Primary Mechanism Of Cytotoxicity Of The ... - PNAS
10 thg 2, 2020 · CX-5461 was discovered and described as an RNA polymerase I inhibitor (7, 8), but it was recently suggested to stabilize G-quadruplex DNA and ...
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6.The RNA Polymerase I Transcription Inhibitor CX-5461 Cooperates ...
11 thg 11, 2020 · The RNA polymerase I transcription inhibitor CX-5461 cooperates with topoisomerase 1 inhibition by enhancing the DNA damage response in ...
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7.CX-5461 Treatment Leads To Cytosolic DNA-Mediated ... - NCBI
9 thg 10, 2021 · CX-5461 is an RNA polymerase I inhibitor that is in clinical trials for both advanced hematological cancers and solid tumors.
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8.FDA Grants Fast-Track Designation To CX-5461 In Treatment Of ...
26 thg 1, 2022 · CX-5461 is a G4-stablizing compound that acts in tandem with HR pathway deficiency, aiming to stabilize folded conformation and stall DNA ...
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9.CX-5461 | RNA Polymerase I Inhibitor - MedChemExpress
Description. CX-5461 is a potent and oral rRNA synthesis inhibitor. It inhibits RNA polymerase I-driven transcription of rRNA with IC50s of 142, 113, and 54 nM ...
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10.Chemotherapeutic Agent CX-5461 Irreversibly Blocks RNA ...
In the search for drugs to effectively treat cancer, the last 10 years have seen a resurgence of interest in targeting ribosome biogenesis. CX-5461 is a ...
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11.Discovery Of CX-5461, The First Direct And Selective Inhibitor Of RNA ...
8 thg 5, 2012 · The preclinical data support the development of CX-5461 as an anticancer drug with potential for activity in several types of cancer.
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12.FDA Grants Fast Track Status To CX-5461 For Breast And Ovarian ...
25 thg 1, 2022 · CX-5461 is currently under investigation in an open-label, multicenter phase 1b trial (NCT04890613), which seeks to determine a tolerable dose ...
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13.Phase 1b Expansion Study Of CX-5461 In Patients With Solid Tumors ...
19 thg 1, 2022 · CX-5461, a G-quadruplex stabilizer, employs an alternative mechanism in destabilizing the DNA replication fork to promote DNA damage ...
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14.CX-5461 Treatment Leads To Cytosolic DNA-Mediated STING ...
CX-5461 is an RNA polymerase I inhibitor that is in clinical trials for both advanced hematological cancers and solid tumors. Experimentally, this drug has ...
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