Dr Dong Gui Hu - Research @ Flinders

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Dr Dong Gui Hu

• Academic Status, College of Medicine and Public Health
• Full Member, College of Medicine and Public Health, Flinders Health and Medical Research Institute

 https://orcid.org/0000-0002-4879-348X

• h-index

• 1352 Citations
• 20 h-index

Calculated based on number of publications stored in Pure and citations from Scopus 19992024

Research activity per year

• Overview
• Fingerprint
• Network
• Research Outputs (45)
• Similar Profiles (6)

Personal profile

Research Interests

Dr Hu's research over the last 17 years has been focusing on deciphering molecular mechanisms controlling the expression and activity of UDP-glucuronosyltransferases (UGTs) in response to therapeutic drugs and signalling molecules such as sex steroid hormones. These studies discovered a series of transcriptional factors and microRNAs that control  UGT expression and function in drug-metabolically relevant organs (Liver) and sex hormone-sensitive cancers (Prostate and Breast cancer). These studies have been published in over 20 articles in prestigious international journals in the fields of Pharmacology and Cancers, including Molecular pharmacology, Journal of Pharmacology and Experimental Therapeutics, Drug Metabolism and Disposition, Drug Metabolism Reviews, Pharmacology & Therapeutics, cancers, and Cancer Research.

Dr Hu's research on UGT genes also recently extends to define novel alternatively spliced UGT transcripts, including circular and chimeric transcripts that have been published in Molecular Pharmacology.

Dr Hu's research recently extends to cover ADME genes, a group of approximately 300 genes that are involved in drug Absorption, Distribution, Metabolism, Excretion (ADME). ADME genes are also involved in clearing endogenous compounds (steroids, fatty acids, bile acids, lipids). Dr Hu's published bioinformatic analysis of The Cancer Genome Atlas (TCGA) datasets reported widespread deregulation of ADME genes in cancers and their association with cancer patient survival. These discoveries highlight the potentials for ADME genes as prognostic and diagnostic biomarkers for human cancers.

Dr Hu's recent research also discovered novel androgen receptor splice variants (ARVs) and showed for the first time ARV expression in breast cancer.  These discoveries are clinically relevant given their potential role in mediating anti-androgen resistance in breast cancers treated with anti-antiandrogens.

Research Areas

• Molecular biosciences

Supervisory Interests

• Molecular biology
• Drug metabolising enzymes, cytochrome P450 and UDP-glucuronosyltransferase

Fingerprint

Dive into the research topics where Dong Gui Hu is active. These topic labels come from the works of this person. Together they form a unique fingerprint.

• 6 Similar Profiles

• Glucuronosyltransferase Biochemistry, Genetics and Molecular Biology 100%
• Glycosyltransferase Biochemistry, Genetics and Molecular Biology 78%
• Uridine Diphosphate Biochemistry, Genetics and Molecular Biology 78%
• Cancer Cell Biochemistry, Genetics and Molecular Biology 65%
• Breast Cancer Medicine and Dentistry 60%
• Exon Biochemistry, Genetics and Molecular Biology 46%
• Androgen Receptor Biochemistry, Genetics and Molecular Biology 41%
• Metabolic Pathway Biochemistry, Genetics and Molecular Biology 36%

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Collaborations and top research areas from the last five years

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Research output

Research output per year 1999 2010 2014 2015 2016 2017 2018 2019 2021 2024

• 31 Article
• 5 Review article
• 3 Abstract
• 2 Chapter
• 4 More
  • 2 Meeting Abstract
  • 1 Paper
  • 1 Conference article

Research output per year

Research output per year

• A Comprehensive Bioinformatic Analysis of RNA-seq Datasets Reveals a Differential and Variable Expression of Wildtype and Variant UGT1A Transcripts in Human Tissues and Their Deregulation in Cancers

  Hu, D. G., Marri, S., Hulin, J. A., McKinnon, R. A., Mackenzie, P. I. & Meech, R., 13 Jan 2024, In: Cancers. 16, 2, 23 p., 353.

  Research output: Contribution to journal › Article › peer-review

  Open AccessFile
  • UGT1A@ 100%
  • RNA Sequencing 100%
  • Bioinformatics 100%
  • Glucuronidation 28%
  • Esophagus 14%
  61 Downloads (Pure)

• Activation of Cryptic Donor Splice Sites within the UDP-Glucuronosyltransferase (UGT)1A First-Exon Region Generates Variant Transcripts That Encode UGT1A Proteins with Truncated Aglycone-Binding Domains

  Hu, D. G., Marri, S., Hulin, J.-A., Ansaar, R., Mackenzie, P. I., McKinnon, R. A. & Meech, R., 1 Jun 2024, In: Drug Metabolism and Disposition. 52, 6, p. 526-538 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Binding Domain 100%
  • Exon 100%
  • UGT1A@ 100%
  • Glucuronosyltransferase 100%
  • Aglycone 100%

• Regulation of human UDP-glycosyltransferase (UGT) genes by miRNAs

  Hu, D. G., Mackenzie, P. I., Hulin, J. A., McKinnon, R. A. & Meech, R., 2022, In: Drug Metabolism Reviews. 54, 2, p. 120-140 21 p.

  Research output: Contribution to journal › Review article › peer-review

  • Glycosyltransferase 100%
  • Uridine Diphosphate 100%
  • MicroRNA 71%
  • Untranslated Region 57%
  • UGT1A@ 42%
  7 Citations (Scopus)

• The Somatic Mutation Landscape of UDP-Glycosyltransferase (UGT) Genes in Human Cancers

  Hu, D. G., Marri, S., Hulin, J.-A., McKinnon, R., Mackenzie, P. & Meech, R., 2 Nov 2022, In: Cancers. 14, 22, 28 p., 5708.

  Research output: Contribution to journal › Article › peer-review

  Open AccessFile
  • Glycosyltransferase 100%
  • Somatic Mutation 100%
  • Uridine Diphosphate 100%
  • Anticancer 40%
  • Bile Acid 10%
  4 Citations (Scopus) 87 Downloads (Pure)

• Circular RNAs of UDP-Glycosyltransferase (UGT) genes expand the complexity and diversity of the UGT transcriptome

  Hu, D. G., Mackenzie, P., Hulin, J.-A., McKinnon, R. & Meech, R., 1 Jun 2021, In: Molecular Pharmacology. 99, 6, p. 488-503 16 p., 000225.

  Research output: Contribution to journal › Article › peer-review

  • Circular RNA 100%
  • Transcriptome 100%
  • Glycosyltransferase 100%
  • Uridine Diphosphate 100%
  • Human Cell 23%
  5 Citations (Scopus)

View all 45 research outputs