EP300 Acetylates Histone H2A, H2B, H3, H4 - Reactome

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EP300 acetylates histone H2A, H2B, H3, H4

Stable Identifier R-HSA-3662335 Type Reaction [transition] Species Homo sapiens Compartment nucleoplasm ReviewStatus 5/5 Locations in the PathwayBrowser Expand all Chromatin organization (Homo sapiens)
    • Chromatin modifying enzymes (Homo sapiens)
      • HATs acetylate histones (Homo sapiens)
        • EP300 acetylates histone H2A, H2B, H3, H4 (Homo sapiens)
General SBML | BioPAX Level 2 Level 3 | PDF SVG | PNG Low Medium High | PPTX | SBGN EP300 acetylates histone H2A, H2B, H3, H4 Click the image above or here to open this reaction in the Pathway Browser The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout EP300 and the related CREBBP are transcriptional regulators that interact with many other proteins. They have overlapping functions but also unique properties, particularly in vivo (Kalkhoven 2004). CREBBP and EP300 proteins are able to form a physical bridge between DNA-binding transcription factors and the RNA polymerase II complex. Histones are believed to be their main acetylation targets, but their ability to acetylate and thereby regulate transcription factors such as p53 (Gu & Roeder 1997) is also believed to be crucial (Kasper et al. 2006). EP300 can acetylate lysine-6 of histone H2A (H2AK5), lysines-12 (H2BK11), 15 (H2BK14) and to a lesser extent 5 and 20 of histone H2B, but preferentially acetylates lysines 14 and 18 of histone H3 and lysines 5 and 8 of histone H4 (Ogryzko et al. 1996, Schiltz et al. 1999). Heterozygous knockout of Ep300 is embryonic-lethal (Yao et al. 1998). Conditional knockouts have a phenotype that overlaps with that of conditional CREBBP knockouts (Kasper et al. 2006). Literature References
PubMed ID Title Journal Year
9880483 Overlapping but distinct patterns of histone acetylation by the human coactivators p300 and PCAF within nucleosomal substrates

Schiltz, RL, Mizzen, CA, Vassilev, A, Cook, RG, Allis, CD, Nakatani, Y

J. Biol. Chem. 1999
Participants Input
  • Ac-CoA [nucleoplasm]
  • Histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
Output
  • AcK-histone H2A, H2B, H3, H4 [nucleoplasm] (Homo sapiens)
  • CoA-SH [nucleoplasm]
Participates as an event of
  • HATs acetylate histones (Homo sapiens)
Catalyst Activity

histone acetyltransferase activity of EP300 [nucleoplasm]

Physical Entity EP300 [nucleoplasm] (Homo sapiens) Activity histone acetyltransferase activity (GO:0004402) Orthologous Events EP300 acetylates histone H2A, H2B, H3, H4 (Bos taurus) EP300 acetylates histone H2A, H2B, H3, H4 (Drosophila melanogaster) EP300 acetylates histone H2A, H2B, H3, H4 (Gallus gallus) EP300 acetylates histone H2A, H2B, H3, H4 (Xenopus tropicalis) Authored Jupe, S (2013-03-12) Reviewed Karagiannis, T (2013-11-18) Created Jupe, S (2013-06-07)
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