Facile Access To 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H ...

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L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives†

Shaik Karamthulla,a Suman Pal,a Tasneem Parvinb and Lokman H. Choudhury*a Author affiliations

* Corresponding authors

a Department of Chemistry, Indian Institute of Technology Patna, Patna-800013, India E-mail: lokman@iitp.ac.in Fax: +91 612 227 7383 Tel: +91 612 2552038

b Department of Chemistry, National Institute of Technology Patna, Ashok Rajpath, Patna-800 005, India

Abstract

A series of 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives has been synthesized from the three component reactions of 2-hydroxy-1,4-naphthoquinone, aldehydes, and aminopyrazoles in the presence of a catalytic amount of L-proline. This domino reaction proceeds smoothly in good to excellent yields and offers several advantages including no column chromatography, a simple reaction procedure, metal-free reaction conditions and being applicable to a broad range of aldehydes.

Graphical abstract: L-proline catalyzed multicomponent reactions: facile access to 2H-benzo[g]pyrazolo[3,4-b]quinoline-5,10(4H,11H)-dione derivatives You have access to this article Please wait while we load your content...

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