Family C69 - MEROPS - The Peptidase Database
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Summary Holotypes Alignment Tree Genomes Literature H-seq M-seq Architecture
Summary for family C69
| Family type peptidase | C69.001 - dipeptidase A (Lactobacillus helveticus), MEROPS Accession MER0002163 (peptidase unit: 6-474) |
| Content of family | Peptidase family C69 contains dipeptidases and aminopeptidases. |
| History | Identifier created: MEROPS 6.5 (22 December 2003) |
| Catalytic type | Cysteine |
| Active site residues | C6 |
| Active site | Catalytic residues were tentatively identified by sequence comparison with penicillin V acylase (C59.001) and other N-terminal nucleophile hydrolases (Pei & Grishin, 2003). The alignments highlighted the conservation of two regions of hydrophobic residues located between the catalytic Cys and the conserved Arg/Lys and Asp residues (see the Alignment). |
| Activities and specificities | It has been demonstrated that dipeptidase A (C69.001) is able to cleave Leu Leu and PheLeu, but not Leu-Leu-NH2 and Phe-Leu-NH2, indicating that the enzyme can only cleave dipeptides with a free C-terminus (Dudley & Steele, 2004). The peptidase is also unable to cleave bonds involving proline (Vesanto et al., 1996). |
| Inhibitors | Dipeptidase A (C69.001) is inhibited by p-hydroxymercuribenzoate (Vesanto et al., 1996). |
| Molecular structure | No three-dimensional structure is available for any member of the family. The molecular mass of native dipeptidase A was estimated to be 420 kDa and the monomeric mass deduced as 53.5 kDa, suggesting that dipeptidase A is an octamer (Vesanto et al., 1996). |
| Clan | PB |
| Subclan | PB(C) |
| Distribution of family | Bacteria | details |
| Archaea | details | |
| Protozoa | details | |
| Fungi | - | |
| Plants | details | |
| Animals | details | |
| Viruses | - |
| Biological functions | ||
| Statistics for family C69 | Sequences: | 2310 |
| Identifiers: | 6 | |
| Identifiers with PDB entries: | 0 | |
| Downloadable files | Sequence library (FastA format) | |
| Sequence alignment (FastA format) | ||
| Phylogenetic tree (Newick format) | ||
| Other databases | INTERPRO | IPR005322 | ||
| PANTHER | PTHR12994 | |||
| PFAM | PF03577 | |||