Fan Bai-Beijing Advanced Innovation Center For Genomics

Profile

　　Dr. Fan Bai received BSc (Physics) from Peking University in 2003 and DPhil (Biophysics) from University of Oxford in 2008. He returned to China in 2011 and led his own research team. Dr. Fan Bai is pioneering the application of single cell sequencing in biomedical research. Dr. Bai and collaborators published the world's first whole genome sequencing of individual circulating tumor cells collected from cancer patients' peripheral blood (PNAS 2013, Genome Research 2017, Clinical Cancer Research 2019) and received broad media coverage. Recently, Dr. Fan Bai’s team investigated

　　multiple tumor lesions in patients with Hepatocellular Carcinoma, revealing remarkable intra-tumor heterogeneity and the genetic feature of intra- liver metastases (Gastroenterology 2016, Cancer Cell 2019). By combining single-bacterium fluorescent imaging and sequencing, Dr. Fan Bai’s team has revealed the mechanism underlying bacterial antibiotic persistence (Molecular Cell 2016, Molecular Cell 2019, received editorial comments from Nature).

　　The Bai Lab studies the frontiers of biomedical research by combining cutting-edge single-molecule fluorescence imaging and single-cell sequencing, aiming at:

1. study circulating tumor cells to gain deeper insights into the molecular mechanism of cancer metastasis and explore its clinical value for non- invasive cancer diagnosis, prognosis and therapy evaluation,
2. study the genomic features of Chinese cancers,
3. study bacterial motility, virulence, and mechanisms of antibiotic killing and bacterial drug resistance and tolerance.

Selected Publications

1. Li F#, Xing X#, Jin Q#, ……, Yu C*, Chen L*, Bai F*, Gao D*, Sex differences orchestrated by androgens at single-cell resolution, Nature 629 (2024), 193-200
2. Chen L#, Zhang C#, Xue R#, ……, Wu L*, Rozen SG*, Bai F*, Wang H*, Deep whole genome analysis of 494 hepatocellular carcinomas, Nature 624 (2024), 586-593
3. Li R#, Di L#, Li J#, Fan W#, etc., Lin D*, Huang Y*, Wang J*, Bai F*, Wu C*, A body map of somatic mutagenesis in morphologically normal human tissues, Nature 597 (2021), 398-403
4. Wang J#, Xu Y#, Chen Z#, Liang J#, Lin Z#, Liang H#, ……, Bai F*, Xia H*, Wen Z*, Zhang Y*, Liver immune profiling reveals pathogenesis and therapeutics for biliary atresia, Cell 183 (2020), pp. 1867-1883
5. Li R#, Du Y#, Chen Z#, Xu D#, Lin T#, Jin S, Wang G, Liu Z, Lu M, Chen X, Xu T*, Bai F*, Macroscopic somatic clonal expansion in morphologically normal human urothelium, Science 370 (2020), pp. 82-89
6. Jin S#, Li R#, Chen M#, Yu C#, Tang L#, …….., Mai H, Gewurz B, Zhao B, Young L, Zhong Q*, Bai F*, Zeng M*, Single-cell transcriptomic analysis defines the interplay between tumor cells, viral infection, and the microenvironment in nasopharyngeal carcinoma, Cell Research 30 (2020), pp. 950-965
7. Zhang J#, Wang X#, Xing X#, Xu Z#, ……., Zhang Y, Zumla A, Maeurer M, Bai F*, Wang F*, Single-cell landscape of immunological responses in patients with COVID-19, Nature Immunology 21 (2020), pp. 1107-1118
8. Zhang C#, Zhang L#, Xu T#, Xue R#, Yu L#, Zhu Y, Wu Y, Zhang Q, Li D, Shen S, Tan D, Bai F*, Zhang H*, Mapping the spreading routes of lymphatic metastases in human colorectal cancer, Nature Communications 11 (2020), 1993
9. Wang X#, Lu Y#, Song Y#, Dong J#, Li R, Wang G, Wang X, Zhang S, Dong Z, Lu M, Wang S, Ge L, Luo G, Ma R, Rozen S, Bai F*, Wu D*, Ma L*, Integrative genomic study of Chinese clear cell renal cell carcinoma reveals features associated with thrombus, Nature Communications 11 (2020), 739
10. Huang B#, Chen Z#, Geng L#, Wang J#, Liang H#, ......, Gong S*, Bai F*, Yang M*, Zhang Y*, Mucosal profiling of pediatric-onset colitis and IBD reveals common pathogenics and therapeutic pathways, Cell 179 (2019), pp. 1160-1176