FlyBase Reference Report: Hu Et Al., 2019, Cell Rep. 26(6): 1369

• Tools
  • Tools Overview & Help
  • Query by symbols/IDs
    • Batch Download
    • Sequence Downloader
    • ID Validator
    • Feature Mapper
  • Search/Browse Portals
    • QuickSearch
    • Vocabularies
    • QueryBuilder
    • CytoSearch
    • Sequenced Species
    • Interactions Browser
    • ImageBrowse
  • Genomics Tools
    • BLAST
    • Fly BLAST @ Alliance
    • JBrowse
    • CytoSearch
    • Feature Mapper
    • Chromosome Maps
    • Synteny Table
    • Coordinates Converter
    • Sequence Downloader
    • modENCODE RNA-Seq
      • Overview
      • RNA-Seq Similarity
      • RNA-Seq Profile
      • RNA-Seq By Region
      • JBrowse
  • Submit Data
    • Fast-Track Your Paper
    • Submit Personal Communication
    • Feedback on Gene Snapshots
• Downloads
  • Overview
  • Current Release
  • Archived Data
  • Map Conversion
  • Releases (FTP)
• Links
  • External Resources
  • Model Organisms (MODs)
    • Alliance of Genome Resources
    • BeeBase
    • DictyBase
    • EcoCyc
    • Gramene
    • MGI
    • PomBase
    • Pseudobase
    • RGD
    • SGD
    • TAIR
    • VectorBase
    • WormBase
    • Xenbase
    • ZFIN
  • Stock Collections
    • Bloomington Drosophila Stock Center (BDSC)
    • FlyORF
    • Korea Drosophila Resource Center (KDRC)
    • Kyoto Stock Center
    • NIG-FLY
    • Tsinghua Fly Center (THFC)
    • Vienna Drosophila Resource Center (VDRC)
  • BDGP
  • DGRC
  • DRSC/TRiP
  • DIS by issue
  • FlyBook
  • FlyExpress
  • Interactive Fly
  • Virtual Fly Brain
  • FlyCyc
• Community
  • Fast-Track Your Paper
  • FlyBase Community Advisory Group
  • Fly Lab List
  • Recent Papers With Technical Advances
  • Gene Snapshots
  • FlyBase Forum
  • Newsletter
  • FlySlack Community
  • Mastodon
  • Bluesky
  • X (formerly Twitter)
  • Fly Board
  • NIH Funding
• About
  • Release Notes
  • New In This Release
  • Release Schedule
  • FlyBase Positions
  • Citing FlyBase
  • FlyBase Licensing
  • FlyBase Consortium
  • FlyBase Publications
  • FlyBase Presentations
  • Grants Supporting FlyBase
• Help
  • Contact FlyBase
  • FlyBase Wiki:
  • Help Index
  • Tool help
  • Report help
  • FlyBase FAQ
  • Info for Authors
    • Author guidelines
    • Citing FlyBase
    • Fast-Track Your Paper Help
    • Gene Snapshots
    • Personal communications
  • Linking to/from FlyBase
  • Nomenclature
  • Curation documentation
    • Controlled Vocabularies in FlyBase
    • Gene Model Annotation
    • Gene Ontology (GO) Annotation
    • Nontraditional alleles
    • Vectors & Constructs
  • New to Flies?
  • Video Tutorials
  • Programmatic Access to FlyBase: APIs, etc.

FlyBase in AWS Open Data FlyBase NIH Grant Terminated Previous Next FB2025_05 , released December 11, 2025 Open Close Reference Citation Hu, Y., Wang, Z., Liu, T., Zhang, W. (2019). Piezo-like Gene Regulates Locomotion in Drosophila Larvae. Cell Rep. 26(6): 1369--1377.e4. FlyBase ID FBrf0241386 Publication Type Research paper Abstract To maintain proper locomotive patterns, animals constantly monitor body posture with their proprioceptive receptors. In Drosophila, the chordotonal organs (Cho) are especially important in the regulation of locomotion pattern. However, how Cho neurons that are normally activated with sound (vibration) transduce static displacement caused by body position change remains unclear. Here, we report that piezo-like (pzl), a homolog for mammalian piezo1 and 2, is essential for Cho's function in locomotion. The mutant allele of pzl showed severe defects in crawling pattern and body gesture control, which were rescued by expressing Pzl specifically in Cho neurons. The ability of Cho neurons to respond to micrometer-scale body wall displacement requires pzl. Intriguingly, human or mouse Piezo1 can rescue pzl-mutant phenotypes, suggesting a conserved role of the Piezo-family proteins in locomotion. PubMed ID 30726723 PubMed Central ID DOI 10.1016/j.celrep.2019.01.055 Associated Information Comments Associated Files Other Information Secondary IDs Language of Publication English Additional Languages of Abstract Parent Publication Publication Type Journal Abbreviation Cell Rep. Title Cell reports ISBN/ISSN 2211-1247 Data From Reference Alleles (14) Export to HitList

• Hsap\KCNJ2UAS.EGFP
• Hsap\PIEZO1UAS.cJa
• Mmus\Piezo1UAS.GFP
• PzlKK115662
• PzlKO
• PzlU6.sgRNA
• PzlUAS.EGFP
• Scer\GAL4GH298
• Scer\GAL4iav.PP
• Scer\GAL4Pzl.1.5
• Scer\GAL4Pzl.1
• Scer\GAL4Pzl.2
• Scer\GAL4Pzl.5
• Spyo\Cas9UAS.Tag:NLS(Unk)

Genes (7) Export to HitList

• Hsap\KCNJ2
• Hsap\PIEZO1
• Mmus\Piezo1
• nompC
• Pzl
• Scer\GAL4
• Spyo\Cas9

Cell Lines (1) Export to HitList

• S2-DRSC

Natural transposons (1) Export to HitList

• P-element

Insertions (1) Export to HitList

• P{GawB}GH298

Experimental Tools (4) Export to HitList

• EGFP
• GAL4
• GFP
• UAS

Transgenic Constructs (12) Export to HitList

• P{KK115662}
• P{Pzl-GAL4.1.5}
• P{Pzl-GAL4.1}
• P{Pzl-GAL4.2}
• P{Pzl-GAL4.5}
• P{U6-pzl.sgRNA}
• P{UAS-Cas9.C}
• P{UAS-hPIEZO1-IRES-GFP}
• P{UAS-Hsap\KCNJ2.EGFP}
• P{UAS-mPiezo1.GFP}
• P{UAS-Pzl.EGFP}
• PBac{iav-GAL4.P}

Transcripts (1) Export to HitList

• Scer\GAL4Pzl.2RA

Report Sections

Open Close

• Reference
• Associated Information
• Other Information
• Parent Publication
• Data From Reference