Gene ResultKlp31E Kinesin-like Protein At 31E [ (fruit Fly)] - NCBI

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Create FileAdd to ClipboardAdd to Collections Klp31E Kinesin-like protein at 31E [ Drosophila melanogaster (fruit fly) ] Gene ID: 34422, updated on 19-Nov-2025 Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA)

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Summary

Go to the top of the page Help Official Symbol Klp31Eprovided by FlyBase Official Full Name Kinesin-like protein at 31Eprovided by FlyBase Primary source FLYBASE:FBgn0032243 Locus tag Dmel_CG5300 See related AllianceGenome:FB:FBgn0032243 Gene type protein coding RefSeq status REVIEWED Organism Drosophila melanogaster Lineage Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora Also known as CG5300; DmCG5300; Dmel\CG5300; DmKlp31D; DmKlp31E; KIF 21A; KIF21A/B; KLP31E Summary Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Predicted to be involved in microtubule-based movement. Predicted to be part of kinesin complex. Predicted to be active in cytoplasm and microtubule. Is expressed in organism. Human ortholog(s) of this gene implicated in congenital fibrosis of the extraocular muscles 1. Orthologous to human KIF21A (kinesin family member 21A) and KIF21B (kinesin family member 21B). [provided by Alliance of Genome Resources, Jul 2025] Orthologs all NEW Try the new Gene table Try the new Transcript table

Genomic context

Go to the top of the page Help See Klp31E in Genome Data Viewer Location: 31E1-31E1; 2-42 cM Exon count: 12
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (10414017..10418991)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (10414017..10418991)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence: NT_033779.5 Chromosome 2L Reference Release 6 plus ISO1 MT Primary Assembly NT_033779.4 Chromosome 2L Reference Release 5 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Three novel mutations in KIF21A highlight the importance of the third coiled-coil stalk domain in the etiology of CFEOM1. Chan WM, et al. BMC Genet, 2007 May 18. PMID 17511870, Free PMC Article
  2. Heterozygous mutations of the kinesin KIF21A in congenital fibrosis of the extraocular muscles type 1 (CFEOM1). Yamada K, et al. Nat Genet, 2003 Dec. PMID 14595441
  3. Acentric chromosome congression and alignment on the metaphase plate via kinetochore-independent forces. Vicars H, et al. Genetics, 2025 Feb 5. PMID 39552081, Free PMC Article
  4. Msps governs acentrosomal microtubule assembly and reactivation of quiescent neural stem cells. Deng Q, et al. EMBO J, 2021 Oct 1. PMID 34368973, Free PMC Article
  5. A kinesin family tree. Kim AJ, et al. J Cell Sci, 2000 Nov. PMID 11034894

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF? Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

  • NCBI Orthologs
    • Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA Inferred from Electronic Annotationmore info  
enables ATP hydrolysis activity IBA Inferred from Biological aspect of Ancestormore info  
enables cytoskeletal motor activity IEA Inferred from Electronic Annotationmore info  
enables microtubule binding IBA Inferred from Biological aspect of Ancestormore info  
enables microtubule binding IEA Inferred from Electronic Annotationmore info  
enables microtubule motor activity IBA Inferred from Biological aspect of Ancestormore info  
enables microtubule motor activity IEA Inferred from Electronic Annotationmore info  
enables nucleotide binding IEA Inferred from Electronic Annotationmore info  
Process Evidence Code Pubs
involved_in microtubule-based movement IBA Inferred from Biological aspect of Ancestormore info  
involved_in microtubule-based movement IEA Inferred from Electronic Annotationmore info  
Component Evidence Code Pubs
is_active_in cytoplasm IBA Inferred from Biological aspect of Ancestormore info  
located_in cytoskeleton IEA Inferred from Electronic Annotationmore info  
part_of kinesin complex IBA Inferred from Biological aspect of Ancestormore info  
is_active_in microtubule IBA Inferred from Biological aspect of Ancestormore info  
located_in microtubule IEA Inferred from Electronic Annotationmore info  
located_in microtubule cytoskeleton IEA Inferred from Electronic Annotationmore info  

General protein information

Go to the top of the page Help Preferred Names Kinesin-like protein at 31E Names CG5300-PA CG5300-PB CG5300-PC CG5300-PE Kinesin3D Klp31E-PA Klp31E-PB Klp31E-PC Klp31E-PE

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range 10414017..10418991 Download GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_135554.3 → NP_609398.2  Kinesin-like protein at 31E, isoform A

    See identical proteins and their annotated locations for NP_609398.2

    Status: REVIEWED

    UniProtKB/TrEMBL Q9NGN7, Q9VKW4 Related FBpp0079608 Conserved Domains (4) summary smart00129Location:13 → 370 KISc; Kinesin motor, catalytic domain. ATPase cd01372Location:12 → 364 KISc_KIF4; Kinesin motor domain, KIF4-like subfamily pfam14662Location:409 → 589 KASH_CCD; Coiled-coil region of CCDC155 or KASH cl02569Location:685 → 750 RasGAP; Ras GTPase Activating Domain

  2. NM_001169466.2 → NP_001162937.2  Kinesin-like protein at 31E, isoform E

    See identical proteins and their annotated locations for NP_001162937.2

    Status: REVIEWED

    UniProtKB/TrEMBL E1JHE1, Q9NGN7 Conserved Domains (3) summary smart00129Location:13 → 370 KISc; Kinesin motor, catalytic domain. ATPase cd01372Location:12 → 364 KISc_KIF4; Kinesin motor domain, KIF4-like subfamily cl02569Location:684 → 749 RasGAP; Ras GTPase Activating Domain

  3. NM_001169465.2 → NP_001162936.1  Kinesin-like protein at 31E, isoform C

    See identical proteins and their annotated locations for NP_001162936.1

    Status: REVIEWED

    UniProtKB/TrEMBL Q9NGN7, Q9VKW4 Conserved Domains (4) summary smart00129Location:13 → 370 KISc; Kinesin motor, catalytic domain. ATPase cd01372Location:12 → 364 KISc_KIF4; Kinesin motor domain, KIF4-like subfamily pfam14662Location:409 → 589 KASH_CCD; Coiled-coil region of CCDC155 or KASH cl02569Location:685 → 750 RasGAP; Ras GTPase Activating Domain

  4. NM_001169464.1 → NP_001162935.1  Kinesin-like protein at 31E, isoform B

    See identical proteins and their annotated locations for NP_001162935.1

    Status: REVIEWED

    UniProtKB/TrEMBL Q9NGN7, Q9VKW4 Conserved Domains (4) summary smart00129Location:13 → 370 KISc; Kinesin motor, catalytic domain. ATPase cd01372Location:12 → 364 KISc_KIF4; Kinesin motor domain, KIF4-like subfamily pfam14662Location:409 → 589 KASH_CCD; Coiled-coil region of CCDC155 or KASH cl02569Location:685 → 750 RasGAP; Ras GTPase Activating Domain
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Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JHE1 E1JHE1
Q9NGN7 Q9NGN7
Q9VKW4 Q9VKW4
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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
  • Dryad Digital Repository
    • Dryad Digital Repository
Molecular Biology Databases
  • Bgee database
    • Klp31E gene expression
  • BioGPS
    • BioGPS
  • BioGRID Open Repository of CRISPR Screens (ORCS)
    • BioGRID CRISPR Screen Phenotypes (0 hits/3 screens)
  • CTD: Comparative Toxicogenomics Database
    • CTD: Comparative Toxicogenomics Database - KLP31E
  • Eukaryotic Promoter Database
    • Klp31E_1
  • GlyGen glycoinformatics resource
    • GlyGen glycoinformatics resource
  • Kyoto Encyclopedia of Genes and Genomes
    • dme:Dmel_CG5300
  • OMA Browser: Orthologous MAtrix
    • OMA Browser: Orthologous MAtrix
    • OMA Browser: Orthologous MAtrix
    • OMA Browser: Orthologous MAtrix
  • OrthoDB catalog of orthologs
    • Orthologs
Research Materials
  • Addgene Non-profit plasmid repository
    • Get Plasmids - Addgene
  • GenScript latest version of gene cDNA ORF Clone
    • GenScript latest version of gene cDNA ORF Clone
Tools
  • GeneMANIA
    • GeneMANIA
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Supplemental Content

Table of contents

  • Summary
  • Genomic context
  • Genomic regions, transcripts, and products
  • Bibliography
  • Interactions
  • General gene information Homology, Gene Ontology
  • General protein information
  • NCBI Reference Sequences (RefSeq)
  • Related sequences
  • Additional links

Genome Browsers

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Related information

  • BioAssay by Target (List) BioAssays related to the gene by protein target or RNAi target
  • BioAssay, by Gene target PubChem BioAssays done on the Gene target
  • BioAssays, RNAi Target, Tested BioAssays that contain the gene as the target of a RNAi reagent
  • BioProjects BioProjects related to a gene
  • Conserved Domains Related CDD
  • Full text in PMC PMC links
  • Full text in PMC_nucleotide Full text in PubMedCentral identified from shared sequence links
  • Functional Class Functional class of the sequence domain architecture
  • Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side
  • Genome Related Genome
  • GEO Profiles Related GEO
  • HomoloGene Related HomoloGene
  • Nucleotide Link to related Nucleotide entry
  • Protein Link to related protein entry
  • PubChem Substance PubChem Substances
  • PubMed Link to related PubMed entry
  • PubMed(nucleotide/PMC) Citations in PubMed identified from shared sequence and PMC links.
  • RefSeq Proteins Link to Protein RefSeqs
  • RefSeq RNAs Link to Nucleotide RefSeq RNAs
  • Taxonomy Link to related taxonomy entry

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