4 thg 2, 2010 · ... replication arrest in the xeroderma pigmentosum variant leads to DNA double-strand breaks, gH2AX formation, and Mre11 relocalization.
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H2AX is a variant of the H2A protein family, which is a component of the histone octomer in nucleosomes. It is phosphorylated by kinases such as ataxia ...
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γ-H2AX is required for the concentration and stabilization of DNA repair proteins and plays a role in both non-homologous end-joining (NHEJ) and homologous ...
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5 thg 7, 2022 · One of the earliest cellular responses to DNA double strand breaks (DSBs) is the phosphorylation of the core histone protein H2AX (termed ...
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The proposed method is based on gH2AX/pH3 biomarkers for the prediction of genotoxic potential of all kind of substances. The combination of the two ...
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Method Description. The method is an in vitro genotoxic 96-well plate format assay for the measurement of histone gH2AX phosphorylation, normally occurring ...
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H2A histone family member X (usually abbreviated as H2AX) is a type of histone protein from the H2A family encoded by the H2AFX gene.
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29 thg 3, 2017 · gamma-H2AX (gH2AX) is the phosphorylated form of histone H2AX and can function as a sensitive marker for double-strand breaks (DSBs), ...
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31 thg 5, 2016 · In this study, we evaluated retrospectively 53 patients with larynx cancer to determine whether gH2AX phosphorylation (pH2AX) alone or in ...
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Understanding the mode of genotoxic action (MoA: aneugen or clastogen) of a genotoxic chemical is another important requirement. The proposed gH2AX/pH3 method ...
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... our work on genotoxicity assay (comet assay on TK6 & gH2AX on keratinocytes and HepG2) in collaboration with the team of in vitro of Galderma R&D.
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The percentage of peripheral blood gH2AX + cells showed an increasing tendency. •. Continuity of DNA damage response appears compromised by a deficient nutrient ...
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22 thg 8, 2019 · Following radiation exposure, histone H2AX is rapidly phosphorylated by ATM and/or DNA-PK kinases at or near the vicinity of DNA DSB sites to ...
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19 thg 3, 2020 · It is well known that a severe cell injury after exposure to ionizing radiation is the induction of DNA double-strand breaks (DSBs).
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