H19 H19, Imprinted Maternally Expressed Transcript [ (house Mouse)]

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Create FileAdd to ClipboardAdd to Collections H19 H19, imprinted maternally expressed transcript [ Mus musculus (house mouse) ] Gene ID: 14955, updated on 1-Dec-2025

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Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA)

In addition, your package will include a detailed data report in both TSV and JSONL formats.

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Summary

Go to the top of the page Help Official Symbol H19provided by MGI Official Full Name H19, imprinted maternally expressed transcriptprovided by MGI Primary source MGI:MGI:95891 See related Ensembl:ENSMUSG00000000031 AllianceGenome:MGI:95891 Gene type ncRNA RefSeq status VALIDATED Organism Mus musculus Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus Also known as EyeLinc6 Summary Acts upstream of or within negative regulation of cell population proliferation; regulation of gene expression; and regulation of growth. Predicted to be located in cytoplasm. Is expressed in several structures, including egg cylinder; eye; genitourinary system; gut; and heart. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); cerebral infarction; mature T-cell and NK-cell lymphoma; teratoma; and urinary system cancer (multiple). Orthologous to human H19 (H19 imprinted maternally expressed transcript). [provided by Alliance of Genome Resources, Jul 2025] Expression Biased expression in liver E18 (RPKM 5536.3), placenta adult (RPKM 4196.2) and 5 other tissues See more Orthologs all Try the new Gene page Try the new Transcripts and proteins table

Genomic context

Go to the top of the page Help See H19 in Genome Data Viewer Location: 7 F5; 7 87.97 cM Exon count: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (142129267..142131883, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (142575530..142578146, complement)

Chromosome 7 - NC_000073.7

Genomic regions, transcripts, and products

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Genomic Sequence: NC_000073.7 Chromosome 7 Reference GRCm39 C57BL/6J NC_000073.6 Chromosome 7 Reference GRCm38.p6 C57BL/6J

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help See details Mouse ENCODE transcriptome data

• Project title: Mouse ENCODE transcriptome data
• Description: RNA profiling data sets generated by the Mouse ENCODE project.
• BioProject: PRJNA66167
• Publication: PMID 25409824
• Analysis date: n/a

Bibliography

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Related articles in PubMed

1. The structure and expression of a novel gene activated in early mouse embryogenesis. Pachnis V, et al. EMBO J, 1988 Mar. PMID 3396539, Free PMC Article
2. H19 controls reactivation of the imprinted gene network during muscle regeneration. Martinet C, et al. Development, 2016 Mar 15. PMID 26980793
3. Inhibition of LncRNAH19 has the effect of anti-tumour and enhancing sensitivity to Gefitinib and Chemotherapy in Non-small-cell lung cancer in vivo. Zhou Y, et al. J Cell Mol Med, 2020 May. PMID 32281297, Free PMC Article
4. The paternal allele of the H19 gene is progressively silenced during early mouse development: the acetylation status of histones may be involved in the generation of variegated expression patterns. Svensson K, et al. Development, 1998 Jan. PMID 9389664
5. LncRNA-H19 induces hepatic stellate cell activation via upregulating alcohol dehydrogenase III-mediated retinoic acid signals. Wang ZM, et al. Int Immunopharmacol, 2020 Jul. PMID 32304991

See all (474) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. Knockdown H19 Accelerated iPSCs Reprogramming through Epigenetic Modifications and Mesenchymal-to-Epithelial Transition. Title: Knockdown H19 Accelerated iPSCs Reprogramming through Epigenetic Modifications and Mesenchymal-to-Epithelial Transition.
2. Long non-coding RNA H19 promotes myoblast fibrogenesis via regulating the miR-20a-5p-Tgfbr2 axis. Title: Long non-coding RNA H19 promotes myoblast fibrogenesis via regulating the miR-20a-5p-Tgfbr2 axis.
3. LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles. Title: LncRNA H19-EZH2 interaction promotes liver fibrosis via reprogramming H3K27me3 profiles.
4. LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels. Title: LncRNA H19 inhibition impairs endoplasmic reticulum-mitochondria contact in hepatic cells and augments gluconeogenesis by increasing VDAC1 levels.
5. The long noncoding RNA lnc-H19 is important for endurance exercise by maintaining slow muscle fiber types. Title: The long noncoding RNA lnc-H19 is important for endurance exercise by maintaining slow muscle fiber types.
6. [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway]. Title: [Long noncoding RNA H19 promotes vascular calcification by repressing the Bax inhibitor 1/optic atrophy 1 pathway].
7. H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection. Title: H19/Mir-130b-3p/Cyp4a14 potentiate the effect of praziquantel on liver in the treatment of Schistosoma japonicum infection.
8. Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice. Title: Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice.
9. Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway. Title: Decreased expression of H19/miR-675 ameliorates muscle atrophy by regulating the IGF1R/Akt/FoxO signaling pathway.
10. In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer. Title: In vivo self-assembled small RNA targets H19 lncRNA for the treatment of colorectal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (172)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

• Endonuclease-mediated (9)  1 citation
• Targeted (10)  1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

• UniSTS:265491 (e-PCR)
  • UniSTS:265491

• H19 (e-PCR), detects polymorphism
  • UniSTS:265491

• UniSTS:265492 (e-PCR)
  • UniSTS:265492

• H19 (e-PCR), detects polymorphism
  • UniSTS:265492

• H19 (e-PCR), detects polymorphism
  • UniSTS:470554

• H19 (e-PCR), detects polymorphism
  • UniSTS:532251

• H19 (e-PCR), detects polymorphism
  • UniSTS:525917

• H19 (e-PCR), detects polymorphism
  • UniSTS:516447

• H19os (e-PCR), detects polymorphism
  • UniSTS:527200

• H19os (e-PCR), detects polymorphism
  • UniSTS:527201

• H19os (e-PCR), detects polymorphism
  • UniSTS:527206

• PMC310880P1 (e-PCR)
  • UniSTS:272787

• H19 (e-PCR), detects polymorphism
  • UniSTS:532137

• H19 (e-PCR), detects polymorphism
  • UniSTS:143288

• H19 (e-PCR), detects polymorphism
  • UniSTS:143289

• H19 (e-PCR), detects polymorphism
  • UniSTS:143290

• H19 (e-PCR), detects polymorphism
  • UniSTS:143291

• H19 (e-PCR), detects polymorphism
  • UniSTS:143292

• H19 (e-PCR), detects polymorphism
  • UniSTS:143293

• H19 (e-PCR), detects polymorphism
  • UniSTS:143294

• H19 (e-PCR), detects polymorphism
  • UniSTS:143295

• UniSTS:143296 (e-PCR)
  • UniSTS:143296

• H19 (e-PCR), detects polymorphism
  • UniSTS:143296

• H19 (e-PCR), detects polymorphism
  • UniSTS:143297

• H19 (e-PCR), detects polymorphism
  • UniSTS:516551

• NoName (e-PCR)
  • UniSTS:532168

• H19 (e-PCR), detects polymorphism
  • UniSTS:532168

• H19 (e-PCR), detects polymorphism
  • UniSTS:166619

• AI747191 (e-PCR)
  • UniSTS:179684

• H19 (e-PCR), detects polymorphism
  • UniSTS:465390

• UniSTS:265459 (e-PCR)
  • UniSTS:265459

• H19 (e-PCR), detects polymorphism
  • UniSTS:265459

Homology

• NCBI Orthologs

Other Names

• H19 fetal liver mRNA

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

1. NR_130973.1 RNA Sequence

   Status: VALIDATED

   Description Transcript Variant: This variant (1) represents the longer transcript. Source sequence(s) AK145379, BY770825, W75219 Related ENSMUST00000136359.10

2. NR_130974.1 RNA Sequence

   Status: VALIDATED

   Description Transcript Variant: This variant (2) uses an alternate splice site in an internal exon, compared to variant 1. Source sequence(s) AK145379, BY770825, CV561038, W75219 Related ENSMUST00000152754.10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCm39 C57BL/6J

Genomic

1. NC_000073.7 Reference GRCm39 C57BL/6J

   Range 142129267..142131883 complement Download GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

These RefSeqs were suppressed for the cited reason(s). Suppressed RefSeqs do not appear in BLAST databases, related sequence links, or BLAST links (BLink), but may still be retrieved by clicking on their accession.version below.

1. NM_023123.1: Suppressed sequence

   Description NM_023123.1: This RefSeq record was removed by NCBI staff. Contact [email protected] for further information.

2. NR_001592.1: Suppressed sequence

   Description NR_001592.1: This RefSeq was permanently suppressed because the transcript retains intronic sequences.

Related sequences

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Nucleotide		Protein	Strain
Heading	Accession and Version

Additional links

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Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information

• MilliporeSigma
• H19 products

Molecular Biology Databases

• Bgee database
• H19 gene expression
• BioGPS
• BioGPS
• CTD: Comparative Toxicogenomics Database
• CTD: Comparative Toxicogenomics Database - H19
• Ingenuity Pathways Analysis
• Ingenuity Pathways Analysis

Research Materials

• Addgene Non-profit plasmid repository
• Get Plasmids - Addgene
• GenScript latest version of gene cDNA ORF Clone
• GenScript latest version of gene cDNA ORF Clone
• GeneCopoeia Inc.
• Order miRNA target clones
• Order shRNA clones
• OriGene Technologies
• Order GeneID 14955 cDNA Clone|Lysate|Protein|Antibody|RNAi

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Supplemental Content

Table of contents

• Summary
• Genomic context
• Genomic regions, transcripts, and products
• Expression
• Bibliography
• Variation
• Interactions
• General gene information Markers, Homology
• NCBI Reference Sequences (RefSeq)
• Related sequences
• Additional links

Genome Browsers

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Related information

• Full text in PMC PMC links
• Gene neighbors Overlapping genes and two nearest non-overlapping genes on either side
• Genome Related Genome
• GEO Profiles Related GEO
• Nucleotide Link to related Nucleotide entry
• PubChem Compound PubChem Compounds
• PubChem Substance PubChem Substances
• PubMed Link to related PubMed entry
• PubMed (GeneRIF) Link to related PubMed article from GeneRIFs
• RefSeq RNAs Link to Nucleotide RefSeq RNAs
• Taxonomy Link to related taxonomy entry

Links to other resources

• MGI
• Ensembl
• AllianceGenome
• Gene Expression Database (GXD) at MGI
• UCSC

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