1 thg 2, 2022 · 3 G34-mutant diffuse gliomas in adult patients demonstrated the clinical importance of detecting H3.3 G34R/V mutations. The dismal prognosis of ...
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3 thg 11, 2020 · Overall, we demonstrate that H3.3 G34 oncohistones selectively promote PRC2 activity by interfering with SETD2-mediated H3K36 methylation. We ...
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3 G34-mutant diffuse gliomas were described to present as a histopathologically heterogenous group of neoplasms, with the characteristics of either glioblastoma ...
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In this study, we describe a mechanism by which H3.3 G34 mutations alter gene expression through perturbation of local chromatin modifications. We find that ...
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Overall, we demonstrate that H3.3 G34 oncohistones selectively promote PRC2 activity by interfering with SETD2-mediated H3K36 methylation. We propose that PRC2- ...
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19 thg 4, 2021 · 3 G34-mutant diffuse gliomas as a new WHO grade IV tumor type that should be referred to as “Diffuse hemispheric glioma, H3.3 G34-mutant” and ... Abstract · Material and Methods · Results · Discussion
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29 thg 9, 2020 · H3.3 G34-mutant glioma is extremely rare diffusely infiltrating high-grade astrocytic tumors [8, 26]. Yoshimoto et al. found four H3.3 ...
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7 thg 12, 2020 · Histone H3.3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or ...
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30 thg 9, 2020 · Mutations affecting the G34 residue of histone H3.3 are prevalent in both gliomas and GCTBs. The G34W mutation occurs in most, if not all, GCTBs ...
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The Clinicopathological and Genetic Characteristics of High-grade Gliomas with Histone H3.3 G34 Mutation in Teenagers and Young adults. Yuanyuan Cheng.
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25 thg 5, 2018 · Histone H3 genes, particularly H3F3A and H3F3B, the genes encoding the variant histone H3.3, are mutated at high frequency in pediatric brain ...
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25 thg 1, 2022 · Diffuse hemispheric gliomas, H3 G34 mutant are rare and high grade infiltrating tumors typically presenting in adolescents and young adults.
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H3F3A G34 (H3.3 G34)-mutant high-grade gliomas (HGG) are rare, and newly recognized infiltrating gliomas of the cerebral hemisphere.
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Human Histone H3.3 (Mutated G34W, G34V, G34R) Antibody Panel Antibody panels datasheet (ab274410). Abcam offers quality products including antibodies, ...
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5 thg 7, 2022 · Request PDF | Diagnostic utility of histone H3.3 G34 W, G34R, and G34 V mutant-specific antibodies for giant cell tumors of bone | Giant ...
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