9 thg 7, 2020 · GBMs bearing G34R mutations exhibit genome-wide changes in H3K36me3 profiles and elevated MYCN. More recently, increased expression of NOTCH ...
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Abstract. Pediatric glioblastomas recently have been exon sequenced with evidence that approximately 30 % of cases harbour mutations of the histone H3.3 gene.
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1 thg 6, 2021 · The histone H3.3 G34R/V mutations are known drivers of high-grade pediatric glioma (pHGG). However, the mechanism(s) for H3.3 G34R/V induced ...
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3 G34W or G34R transgenes in cell lines drives a unique gene expression profile that is dependent on histone variant H3.3 and PRC2-mediated methylation in cis.
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6 thg 5, 2021 · Intriguingly, distinct mutations arise in discrete anatomical regions: H3.3-G34R within the forebrain and H3.3-K27M preferentially within ...
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10 thg 12, 2020 · Histone H3.3 glycine 34 to arginine/valine (G34R/V) mutations drive deadly gliomas and show exquisite regional and temporal specificity, ...
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7 thg 12, 2020 · 3 mutation (H3F3A) occurs in 50% of cortical pediatric high-grade gliomas. This mutation replaces glycine 34 with arginine or valine (G34R/V), ...
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20 thg 5, 2019 · The recently described malignant neuro-epithelial tumors with histone H3F3A point mutations at G34 (NET-H3-G34) occur most often in cerebral ...
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A peptide corresponding to Histone H3.3 G34W, G34R, and G34V mutants individually. Application, Western Blot ELISA Immunohistochemistry. Species Reactivity, All.
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Anti-Histone H3.3 G34R, Cat. No. ABE403, is a highly specific rabbit polyclonal antibody that targets Histone H3.3 mutant G34R and has been tested for use ...
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30 thg 11, 2020 · 50% of H3.3 G34R/V high-grade gliomas carry activating. PDGFRA mutations d. G34R/V gliomas originate in GSX2-expressing interneuron.
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15 thg 7, 2020 · One striking aspect of histone H3 mutations is their tumor location and age-specificity: the K27M mutation occurs in midline brain structures in ...
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To do this, we used three human pediatric GBM (pGBM) cell lines (3). SJ-HGGx6c and SJ-HGGx42c are heterozygous for the G34R mutation in H3F3A (referred to as R6 ...
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3 . Immunogen, A peptide corresponding to Histone H3.3 G34R mutant. Application, Western Blot ELISA Immunohistochemistry Chromatin IP. Species ...
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