Top 14+ H3b hay nhất
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1.H3B-8800, An Orally Available Small-molecule Splicing Modulator ...
19 thg 2, 2018 · The small molecule H3B-8800 selectively modulates RNA splicing to preferentially kill tumor cells bearing mutations in genes encoding ...
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2.H3B-8800, An Orally Available Small-molecule Splicing ... - PubMed
Here we describe an orally available modulator of the SF3b complex, H3B-8800, which potently and preferentially kills spliceosome-mutant epithelial and ...
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3.Science | H3 Biomedicine
H3 Biomedicine Clinical Programs · H3B-6545 | Phase 2. Breast Cancer · H3B-6527 | Phase 1. Hepatocellular Carcinoma · H3B-8800 Program | Phase 1. Myelodysplastic ...
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4.Results Of A Clinical Trial Of H3B-8800, A ... - ASH Publications
13 thg 11, 2019 · In pre-clinical models, H3B-8800 preferentially kills spliceosome mutant cells and induces antitumor activity in xenograft leukemia models with ...
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5.Definition Of Splicing Inhibitor H3B-8800 - NCI Drug Dictionary
splicing inhibitor H3B-8800. An orally bioavailable inhibitor of the splicing factor 3B subunit 1 (SF3B1), with potential antineoplastic activity.
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6.H3B-8800: Uses, Interactions, Mechanism Of Action | DrugBank Online
26 thg 4, 2018 · H3B-8800 was granted orphan drug status by the FDA in August 2017 and is in clinical trials for the treatment of acute myelogenous leukemia and ...
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7.EISAI ENTERS INTO EXCLUSIVE LICENSING AGREEMENT WITH ...
6 thg 1, 2022 · H3B-8800 (Roivant's Development Code: RVT-2001) is a splicing modulator compound, discovered by Eisai's U.S. research subsidiary H3 Biomedicine ...
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8.Results Of A Clinical Trial Of H3B-8800, A Splicing Modulator, In ...
13 thg 11, 2019 · H3B-8800 is an orally available small molecule that binds to the SF3b complex and induces alternative splicing changes in cells. Because ...
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9.Phase I/II Study Of H3B-6545, A Novel Selective Estrogen Receptor ...
28 thg 5, 2021 · 1018Background: H3B-6545, a selective, small molecule covalent antagonist of ERα demonstrated preclinical and preliminary clinical activity ...
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10.H3B Ligand Summary Page - RCSB PDB
H3B · 3-trimethylsilylpropane-1-sulfonic acid · Chemical Component Summary · Chemical Details · Related Resource References ...
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11.Phase 1b Study Of H3B-6545 In Combination With Palbociclib In ...
28 thg 5, 2021 · e13025Background: H3B-6545, a highly Selective ERα Covalent Antagonist (SERCA), inactivates both wild-type and mutant ERα by targeting ...
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12.Trial Of H3B-6545, In Women With Locally Advanced Or Metastatic ...
Trial of H3B-6545, in Women With Locally Advanced or Metastatic Estrogen Receptor-positive, HER2 Negative Breast Cancer ...
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13.A Study Of H3B-8800 (RVT-2001) In Participants ... - Clinical Trials
22 thg 7, 2016 · H3B-8800 Acute Myeloid Leukemia or High Risk Myelodysplastic Syndromes/ Low Risk Myelodysplastic Syndromes/ Chronic Myelomonocytic Leukemia.
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14.Recombinant Human B7-H3 (4Ig)/B7-H3b Fc Chimera Protein, CF
2 μg/lane of Recombinant Human B7-H3 (4Ig)/B7-H3b Fc Chimera Protein (10472-B3) was resolved with SDS-PAGE under reducing (R) and non-reducing (NR) ...
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