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Hadacidin/
Molecular structure of Hadacidin, CAS Number: 689-13-4Molecular structure of Hadacidin, CAS Number: 689-13-4Molecular structure of Hadacidin, CAS Number: 689-13-4Hadacidin (CAS 689-13-4)0.0(0)Write a reviewAsk a question
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Alternate Names:Hadacidine; N-Formyl-N-hydroxyglycineCAS Number:689-13-4Molecular Weight:119.08Molecular Formula:C3H5NO4For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.* Refer to Certificate of Analysis for lot specific data.
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Hadacidin was initially extracted from Penicillium frequentans cultures. Structurally, it falls under the categories of monocarboxylic acid, N-hydroxy-alpha-amino-acid, and aldehyde. Notably, hadacidin functions as an inhibitor of AMP synthesis and demonstrates anticancer activity, along with its analogues, by targeting adenylosuccinate synthetase. It exhibits various roles as a teratogenic, antineoplastic, and antimicrobial agent, while also serving as a metabolite of Penicillium.
Hadacidin (CAS 689-13-4) References
Further studies on ammonia formation in brain slices: the effect of hadacidin. | Weil-Malherbe, H. 1975. Neuropharmacology. 14: 175-80. PMID: 1134623
Hadacidin, a new growth-inhibitory substance in human tumor systems. | KACZKA, EA., et al. 1962. Biochemistry. 1: 340-3. PMID: 14452968
Inhibition of adenine nucleotide synthesis: effect on tight junction structure and function of clone 4 MDCK cells. | Ladino, C., et al. 1991. Eur J Cell Biol. 55: 217-24. PMID: 1657607
Genesis of hadacidin-induced cleft palate in hamster: morphogenesis, electron microscopy, and determination of DNA synthesis, cAMP, and enzyme acid phosphatase. | Shah, RM., et al. 1991. Am J Anat. 192: 55-68. PMID: 1661065
[The effect of hadacidin, ultraviolet irradiation of blood (UVB) and thiamine on the prenatal development of Uje:WIST rats: correlation with the hepatic activity of gamma-glutamyltranspeptidase (GGT)]. | Wagner, T., et al. 1991. J Exp Anim Sci. 34: 198-202. PMID: 1687660
AMP deaminase in Dictyostelium discoideum: increase in activity following nutrient deprivation induced by starvation or hadacidin. | Jahngen, EG. and Rossomando, EF. 1986. Mol Cell Biochem. 71: 71-8. PMID: 3014311
Effect of the amino acid analog hadacidin on intracellular membrane flow and the cell surface in Dictyostelium discoideum. A transmission- and scanning-electron-microscope study. | Kinsella, BA., et al. 1986. Differentiation. 31: 100-5. PMID: 3743928
Transport characteristics of two carcinostatic compounds, hydroxyurea and hadacidin, with rat small intestine. | Evered, DF. and Selhi, HS. 1972. Biochem J. 126: 26P. PMID: 5075254
The effects of hadacidin and inosine on hepatic protein synthesis and adenosine triphosphate levels in ethionine-treated rats. | Shull, KH. and Villa-Trevino, S. 1964. Biochem Biophys Res Commun. 16: 101-5. PMID: 5871797
Synthesis of adenosine nucleotides from hypoxanthine by human malaria parasites (Plasmodium falciparum) in continuous erythrocyte culture: inhibition by hadacidin but not alanosine. | Webster, HK., et al. 1984. Biochem Pharmacol. 33: 1555-7. PMID: 6375681
Inhibition of a nutrient-dependent pinocytosis in Dictyostelium discoideum by the amino acid analogue hadacidin. | Rossomando, EF., et al. 1981. J Cell Biol. 91: 227-31. PMID: 7298718
Lysosomal abnormalities in hadacidin-treated Dictyostelium discoideum amoebae. | Crean, EV., et al. 1981. J Gen Microbiol. 123: 253-7. PMID: 7320697
Refined crystal structure of adenylosuccinate synthetase from Escherichia coli complexed with hydantocidin 5'-phosphate, GDP, HPO4(2-), Mg2+, and hadacidin. | Poland, BW., et al. 1996. Biochemistry. 35: 15753-9. PMID: 8961938
Storage :
Store at -20° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
Identification (1H-NMR) Conditions: DMSO-d6, CD3OD, D2OTLC Conditions: SiO2; Dichloromethane : Methanol = 9 : 1; Visualized with UV and KMnO4; Single Spot, Rf = 0.40
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Ordering Information
Product Name
Catalog #
UNIT
Price
Qty
FAVORITES
Hadacidin, 100 mg
sc-490177
100 mg
$460.00
-+
ADD TO CART
Hadacidin, 1 g
sc-490177A
1 g
$2800.00
-+
ADD TO CART
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