Henderson Hasselbalch Equation Relationship Of PH And PKa

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Henderson Hasselbalch equation

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HCO3: meq/L

PCO2: mmHg

Background:

PCO2 is equivalent to PaCO2 Normal values: HCO3: 22-26 meq/L PCO2: 35 - 45 mmHg pH: 7.35 - 7.45 The Henderson-Hasselbalch equation describes the relationship of pH as a measure of acidity with the acid dissociation constant (pKa), in biological and chemical systems. The equation is especially useful for estimating the pH of a buffer solution and finding the equilibrium pH in acid-base reactions.Quick derivation: Carbonic acid (H2CO3) equilibrium: [H+] x [HCO3-] <---> [H2CO3] <---> [CO2] x [H2O] [H+] x [HCO3-] = K x [CO2] x [H2O] K = equilibrium constant pH = pK + log ( [HCO3-] / [CO2] ) pK = -log K -log H+ = -log pK -log (0.03 x PCO2)/ HCO3- pH = pK -log (0.03 x PCO2)/ HCO3- pH = pK +log HCO3-/ (0.03 x PCO2) pK = 6.1 (bicarbonate buffer system)Final: pH = 6.1 +log (HCO3-/ (0.03 x PCO2))

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Henderson Hasselbalch Equation Relationship Of PH And PKa