HIPSC-Tri21-c2-4 - WiCell

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  • hIPSC-Tri21-c2-4
hIPSC-Tri21-c2-4 ** This cell line has an unexpected abnormal karyotype. Please see the karyotype report in the ``Product Information & Testing`` PDF(s) linked below for more information. This cell line, which serves as a model for Down Syndrome (Trisomy 21), was created by reprogramming a Down Syndrome (Trisomy 21) human fibroblast line. This cell line contains (IRES)-TKNEO-polyadenylation site cassette in exon 3 of the Amyloid Precursor Protein (APP) gene on chromosome 21, in one allele, for positive-negative selection with thymidine kinase and neomycin. Additional isogenic disomic cell lines (hIPSC-Di21-c2-4-3 and hIPSC-Di21-c2-4-4) are available from WiCell.
Cell Line Alias Tri C2-4
Cell Type Human iPS
Disease Down syndrome, Trisomy 21
Genetic Alteration/Mutation 47,XX,+21 (Trisomy 21)
Sex Female
Age at Collection 1 Years
Ethnicity Caucasian
Genetically Related Cell Lines  
Reprogramming Method Viral transfection (Lentivirus: Oct4, Sox2, Nanog, Lin28)
Tissue Origin Skin Fibroblast (AG06872)
Provider University of Washington - Dr. David Russell
dbGaP Data  
hPSCReg ID  
NIH Approval  
Pub Med Abstract  
Collection(s) Down syndrome (Russell) Collection
Have you received this cell line previously? Yes No Why we ask If your PI received this cell line previously, the required agreements have already been completed. To check on previous orders or for more information, contact the Contract Manager . Quantity: 1 2 3 4 5 6 7 8 9 10 Learn about our volume discounts Volume discounts on this cell line
  • Quantity
  • 1 - 2
  • 3 - 4
  • 5+
  • Price per vial
  • $1,250.00
  • $1,125.00
  • $1,062.50

Current Lot Information

Lot Number Culture Platform Lot Description Passage Number Banked By Protocol Product Information & Testing
WB67229 mTeSR1/Matrigel   29 WiCell WiCell Feeder Independent Pluripotent Stem Cell Protocol PDF
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  • Stem Cells
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    • Overview of Cell Ordering Process
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    • Contract Cell Banking
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  • Characterization
    • Our Characterization Lab
    • Cytogenetics
      • Karyotyping
      • Fluorescence In Situ Hybridization (FISH)
      • SNP Microarray
    • Mycoplasma
      • Mycoplasma Detection by PCR
    • Characterization Test Request
    • cGMP Testing Services
      • cGMP Karyotype
      • cGMP Fluorescence In Situ Hybridization (FISH)
      • cGMP Short Tandem Repeats (STR)
    • WiCell Cloud LogIn
    • Sample Submission Instructions
    • Identity
      • Short Tandem Repeat (STR)
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  • Stem Cells
    • About Our Cell Lines
    • Catalog of Stem Cell Lines
    • Cell Line Collections
    • Overview of Cell Ordering Process
  • Cell Banking
    • Contract Cell Banking
    • Deposit Cell Lines
    • Request Information
  • Characterization
    • Our Characterization Lab
    • Cytogenetics
      • Karyotyping
      • Fluorescence In Situ Hybridization (FISH)
      • SNP Microarray
    • Mycoplasma
      • Mycoplasma Detection by PCR
    • Characterization Test Request
    • cGMP Testing Services
      • cGMP Karyotype
      • cGMP Fluorescence In Situ Hybridization (FISH)
      • cGMP Short Tandem Repeats (STR)
    • WiCell Cloud LogIn
    • Sample Submission Instructions
    • Identity
      • Short Tandem Repeat (STR)
    • Request Information
  • Resources
    • Stem Cell Protocols
    • Cell Banking Best Practices
    • Rigor and Reproducibility
    • Recurrent Abnormalities
    • WiCell Publication Hub
    • Posters and Publications
    • WiCell Blog
    • Stem Cell Bank Technical Support
    • Overview of Cell Ordering Process
    • WiCell FAQs
  • Other Services
    • Liquid Nitrogen Storage
    • Reagent Testing
      • Quality Control Testing
    • Request Information
  • About Us
    • Our Mission and History
    • Leadership
    • Contact Us
    • UW-Madison Support
    • Meet Our Team
    • Events
    • Careers
  • Stem Cells
    • About Our Cell Lines
    • Catalog of Stem Cell Lines
    • Cell Line Collections
    • Overview of Cell Ordering Process
  • Cell Banking
    • Contract Cell Banking
    • Deposit Cell Lines
    • Request Information
  • Characterization
    • Our Characterization Lab
    • Cytogenetics
      • Karyotyping
      • Fluorescence In Situ Hybridization (FISH)
      • SNP Microarray
    • Mycoplasma
      • Mycoplasma Detection by PCR
    • Characterization Test Request
    • cGMP Testing Services
      • cGMP Karyotype
      • cGMP Fluorescence In Situ Hybridization (FISH)
      • cGMP Short Tandem Repeats (STR)
    • WiCell Cloud LogIn
    • Sample Submission Instructions
    • Identity
      • Short Tandem Repeat (STR)
    • Request Information
  • Resources
    • Stem Cell Protocols
    • Cell Banking Best Practices
    • Rigor and Reproducibility
    • Recurrent Abnormalities
    • WiCell Publication Hub
    • Posters and Publications
    • WiCell Blog
    • Stem Cell Bank Technical Support
    • Overview of Cell Ordering Process
    • WiCell FAQs
  • Other Services
    • Liquid Nitrogen Storage
    • Reagent Testing
      • Quality Control Testing
    • Request Information
  • About Us
    • Our Mission and History
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    • Contact Us
    • UW-Madison Support
    • Meet Our Team
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