Hist1h1d - Histone Cluster 1, H1d - WikiGenes

The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound    Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008) [search][options]Editor

• Edit this page
• Discussion
• History
• Edit alert 
• Permanent link
• Print
• Export

Share

• Send to a friend
• Share

Personal info

• Your homepage
• Your articles
• Create article

 View

• Font size
• Color scheme

Links

LOC611113	Canis lupus familiaris
HIST1H1D	Homo sapiens
HIST1H1D	Macaca mulatta
LOC472227	Pan troglodytes

Homology information is based on Homologene.
• Homologues
• NCBI Gene
• NCBI SNP
• iHOP resource
• SNPedia
• UniProt
• Ensembl

Table of contents

• Disease relevance of Hist1h1d

• High impact information on Hist1h1d

• Biological context of Hist1h1d

• Regulatory relationships of Hist1h1d

• Other interactions of Hist1h1d

• Analytical, diagnostic and therapeutic context of Hist1h1d

About

• Introduction
• Tutorial
• About
• Contact us
• Language [English]

Terms

• Terms of Use
• Privacy Policy
• Open Access

 

 [edit this page]Gene Review: Hist1h1d  -  histone cluster 1, H1dMus musculusSynonyms: H1 VAR.4, H1.3, H1D, H1d, H1f3, ...    Horvath, G.C. et al., Fan, Y. et al., Talasz, H. et al., Lennox, R.W. et al., Dong, Y. et al., et al.    Talasz,  Helliger,  Puschendorf,  Lindner,   Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more. Welcome to WikiGenes! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text.

Ideally this entry shall become one comprehensive and continuous article. Bulleted lists, for instance, were only used because it is impossible to automatically integrate independent facts into a continuous text.

Much of the current information on this page has been automatically compiled from Pubmed.

This precompiled information serves as a substrate and matrix to embed your contributions, but it is by no means the final word - Homo sapiens can do much better!

WikiGenes is a non-profit and open access community project - Read more.

 

Disease relevance of Hist1h1d

• Comparison of the mouse phosphorylation pattern to that in rat C-6 glioma cells showed differences for H1e and H1d [1].
• In contrast, two differentiated (endoderm-like) cell lines derived from teratocarcinomas lack H1b, and one also lacks H1d [2].

 

High impact information on Hist1h1d

• To determine whether one of these H1s, in particular, was responsible for the compensation present in H1(0-/-) mice, each of the three H1 knockout mouse lines was bred with H1(0) knockout mice to generate H1c/H1(0), H1d/H1(0), or H1e/H1(0) double-knockout mice [3].
• The protein kinase inhibitor staurosporine, shown to dephosphorylate histone H1 and down-regulate MMTV in cultured cells, appears only to completely dephosphorylate the H1.3 isoform [4].
• Most of the H1 histones, namely H1a, H1c, H1d/e, and H1(0), completely aggregate polynucleosomes (1.3 kilobase pairs, 6 nucleosomes) at 270-360 nM, corresponding to a molar ratio of six to eight H1 molecules per reconstituted nucleosome [5].
• In this system the wild type H1d promoter was 20-fold stronger than the H1t promoter [6].
• H1b is much less varied, while H1d and H1e are invariant by these electrophoretic criteria [7].

 

Biological context of Hist1h1d

• They also show that neither H1b nor H1d is essential for cell division [2].
• A high degree of nucleotide sequence identity was seen between the H1var.2, rat H1d and human H1b genes, even well beyond the coding region, indicating that these genes are likely homologues [8].
• Using transient transfection assays in mouse fibroblast NIH3T3 cells, we showed that rat H1d contains a downstream region (+21 to +116) that imparts a two- to threefold up-regulation of fused reporters [9].

 

Regulatory relationships of Hist1h1d

• The rat histone H1d gene has intragenic activating sequences that are absent from the testis-specific variant H1t [9].

 

Other interactions of Hist1h1d

• Two of the genes that have not been assigned previously to the five somatic H1 subtypes have been identified as encoding the H1b and H1d subtypes [10].

 

Analytical, diagnostic and therapeutic context of Hist1h1d

• The H1d and H3.2 Omega sequences bound similar and perhaps identical proteins by gel shift analysis [9].

References

1. In vivo phosphorylation of histone H1 variants during the cell cycle. Talasz, H., Helliger, W., Puschendorf, B., Lindner, H. Biochemistry (1996) [Pubmed]
2. The H1 histones and their interphase phosphorylated states in differentiated and undifferentiated cell lines derived from murine teratocarcinomas. Lennox, R.W., Oshima, R.G., Cohen, L.H. J. Biol. Chem. (1982) [Pubmed]
3. Individual somatic H1 subtypes are dispensable for mouse development even in mice lacking the H1(0) replacement subtype. Fan, Y., Sirotkin, A., Russell, R.G., Ayala, J., Skoultchi, A.I. Mol. Cell. Biol. (2001) [Pubmed]
4. Hormone-mediated dephosphorylation of specific histone H1 isoforms. Banks, G.C., Deterding, L.J., Tomer, K.B., Archer, T.K. J. Biol. Chem. (2001) [Pubmed]
5. In vitro binding of H1 histone subtypes to nucleosomal organized mouse mammary tumor virus long terminal repeat promotor. Talasz, H., Sapojnikova, N., Helliger, W., Lindner, H., Puschendorf, B. J. Biol. Chem. (1998) [Pubmed]
6. The testis-specific histone H1t gene is strongly repressed by a G/C-rich region just downstream of the TATA Box. Clare, S.E., Fantz, D.A., Kistler, W.S., Kistler, M.K. J. Biol. Chem. (1997) [Pubmed]
7. Differences in evolutionary stability among mammalian H1 subtypes. Implications for the roles of H1 subtypes in chromatin. Lennox, R.W. J. Biol. Chem. (1984) [Pubmed]
8. Isolation and characterization of two replication-dependent mouse H1 histone genes. Dong, Y., Sirotkin, A.M., Yang, Y.S., Brown, D.T., Sittman, D.B., Skoultchi, A.I. Nucleic Acids Res. (1994) [Pubmed]
9. The rat histone H1d gene has intragenic activating sequences that are absent from the testis-specific variant H1t. Horvath, G.C., Dasgupta, A., Kistler, M.K., Kistler, W.S. Biochim. Biophys. Acta (2003) [Pubmed]
10. The mouse histone H1 genes: gene organization and differential regulation. Wang, Z.F., Sirotkin, A.M., Buchold, G.M., Skoultchi, A.I., Marzluff, W.F. J. Mol. Biol. (1997) [Pubmed]

Contributions to this collaborative article are from individual authors of WikiGenes or mined by the WikiGenes Data Mining Engine from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.About WikiGenesOpen Access LicencePrivacy PolicyTerms of Useapsburg