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Abstract

Hydrogen sulfide (H2S) is an endogenous, gaseous signaling molecule that plays a critical role in cardiac and vascular biology. H2S regulates vascular tone and oxidant defenses and exerts cytoprotective effects in the heart and circulation. Recent studies indicate that H2S modulates various components of metabolic syndrome, including obesity and glucose metabolism. This review will discuss studies exhibiting H2S -derived cardioprotective signaling in heart failure with reduced ejection fraction (HFrEF). We will also discuss the role of H2S in metabolic syndrome and heart failure with preserved ejection fraction (HFpEF).

Keywords: HFpEF; HFrEF; cardiometabolic HFpEF; heart failure; hydrogen sulfide; hydrogen sulfide therapeutics; metabolic syndrome; obesity.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1

Figure 1

H 2 S Mediated Protection…

Figure 1

H 2 S Mediated Protection in Heart Failure.

Figure 1 H2S Mediated Protection in Heart Failure.
Figure 2

Figure 2

H2S and Metabolic Syndrome.

Figure 2

H2S and Metabolic Syndrome.

Figure 2 H2S and Metabolic Syndrome.
Figure 3

Figure 3

Plasma free H 2 S…

Figure 3

Plasma free H 2 S and sulfane sulfure levels in ZSF1 obese rats…

Figure 3 Plasma free H2S and sulfane sulfure levels in ZSF1 obese rats prior at multiple time points in disease progression. (A) Plasma H2S levels at 14 weeks of age (prior to HFpEF onset) and at 26 weeks of age (late-stage HFpEF). (B) Plasma sulfane sulfur levels at 14 and 26 weeks of age. NS: Not Significant, * p < 0.05.
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