Hypotonic Versus Isotonic Maintenance Intravenous Fluid Therapy In ...

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Abstract

A systematic review of studies comparing hypotonic versus isotonic intravenous maintenance fluids in hospitalized children was conducted to determine whether hypotonic solutions increase the risk of acute hyponatremia. Studies were identified from electronic databases and hand-searched reference lists. A total of 283 abstracts were reviewed, 55 full-text articles were retrieved, and 3 studies were included. All studies were observational and were overall inconclusive. All authors cautioned against the routine use of hypotonic maintenance fluids, but hypotonic fluid administration did not always explain the development of acute hyponatremia. Further evidence is required as to the appropriate maintenance solution for hospitalized children.

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  • Can the routine administration of hypotonic parenteral fluids be justified? Moritz ML, Ayus JC. Moritz ML, et al. Clin Pediatr (Phila). 2008 Sep;47(7):725. doi: 10.1177/0009922808317001. Clin Pediatr (Phila). 2008. PMID: 18698103 No abstract available.

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