Implications For Lewy-body Formation In Parkinson Disease - PubMed

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

Nature Publishing Group Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Comment in
• Publication types
• MeSH terms
• Substances
• Grants and funding
• LinkOut - more resources

Title & authors Abstract Comment in Publication types MeSH terms Substances Grants and funding LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

Parkinson disease is a common neurodegenerative disorder characterized by the loss of dopaminergic neurons and the presence of intracytoplasmic-ubiquitinated inclusions (Lewy bodies). Mutations in alpha-synuclein (A53T, A30P) and parkin cause familial Parkinson disease. Both these proteins are found in Lewy bodies. The absence of Lewy bodies in patients with parkin mutations suggests that parkin might be required for the formation of Lewy bodies. Here we show that parkin interacts with and ubiquitinates the alpha-synuclein-interacting protein, synphilin-1. Co-expression of alpha-synuclein, synphilin-1 and parkin result in the formation of Lewy-body-like ubiquitin-positive cytosolic inclusions. We further show that familial-linked mutations in parkin disrupt the ubiquitination of synphilin-1 and the formation of the ubiquitin-positive inclusions. These results provide a molecular basis for the ubiquitination of Lewy-body-associated proteins and link parkin and alpha-synuclein in a common pathogenic mechanism through their interaction with synphilin-1.

PubMed Disclaimer

Comment in

• Linking ubiquitin, parkin and synphilin-1. Ciechanover A. Ciechanover A. Nat Med. 2001 Oct;7(10):1108-9. doi: 10.1038/nm1001-1108. Nat Med. 2001. PMID: 11590431 No abstract available.

Publication types

• Research Support, Non-U.S. Gov't Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Research Support, U.S. Gov't, P.H.S. Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Animals Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Carrier Proteins / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Cell Line Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Glycosylation Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Lewy Bodies Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ligases / genetics Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ligases / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Mutagenesis Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Nerve Tissue Proteins / genetics Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Nerve Tissue Proteins / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Parkinson Disease / metabolism* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Rats Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Synucleins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ubiquitin-Protein Ligases* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ubiquitins / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• alpha-Synuclein Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• Carrier Proteins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Nerve Tissue Proteins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• SNCA protein, human Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• SNCAIP protein, human Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Snca protein, rat Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Sncaip protein, rat Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Synucleins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ubiquitins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• alpha-Synuclein Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ubiquitin-Protein Ligases Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• parkin protein Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Ligases Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Grants and funding

• NS38377/NS/NINDS NIH HHS/United States

LinkOut - more resources

• Full Text Sources

  • Nature Publishing Group

• Other Literature Sources

  • The Lens - Patent Citations Database

• Medical

  • MedlinePlus Health Information

• Molecular Biology Databases

  • BioCyc
  • Gene Ontology
  • GlyGen glycoinformatics resource

• Miscellaneous

  • NCI CPTAC Assay Portal

Full text links [x] Nature Publishing Group [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.