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Search articles by DOI, keyword, author or affiliation Search Close Advanced Search presentation International Journal of Oncology Join Editorial Board Propose a Special Issue Print ISSN: 1019-6439 Online ISSN: 1791-2423 Show Journals Journal Cover December 1996 Volume 9 Issue 6

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Article Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)
  • Authors:
    • J Pinski
    • A Schally
    • A Jungwirth
    • K Groot
    • G Halmos
    • P Armatis
    • M Zarandi
    • M Vadillo-Buenfil

  • View Affiliations / Copyright

    Affiliations: VET AFFAIRS MED CTR,INST ENDOCRINE POLYPEPTIDE & CANC,NEW ORLEANS,LA 70146. TULANE UNIV,SCH MED,DEPT MED,NEW ORLEANS,LA 70146.
  • Pages: 1099-1105 | Published online on: December 1, 1996 https://doi.org/10.3892/ijo.9.6.1099
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Abstract

Insulin-like growth factors-I and-II (IGF-I and IGF-II) may be involved in the proliferation of human lung carcinomas. The purpose of this study was to investigate the effects of two potent antagonists of growth hormone-releasing hormone (GH-RH), MZ-4-71 and MZ-5-156 on the growth of the H69 human small cell lung cancer (SCLC) and H157 non-SCLC (NSCLC) lines transplanted into nude mice or cultured in vitro. Nude mice bearing H69 and H157 tumors were treated for 3-5 weeks with MZ-4-71 or MZ-5-156 injected s.c. twice a day at a dose of 20 mu g/animal. Growth of H69 and H157 tumors in nude mice was significantly inhibited by MZ-4-71 and MZ-5-156 as shown by a reduction in tumor volume and weight. In animals bearing H157 NSCLC, treatment with MZ-4-71 decreased IGF-I and IGF-II levels in tumor tissue. Levels of IGF-I, but not of IGF-II in serum and liver tissue of H157 tumor-bearing nude mice treated with MZ-4-71 were decreased. High affinity binding sites for ICF-I were demonstrated on membranes of H69 and H157 tumors. In cell cultures, the proliferation rate of H69 SCLC cells was suppressed by 10(-7)-10(-5) M MZ-4-71, but H157 NSCLC line was only inhibited by 10(-5) M antagonist. Our findings demonstrate that the GHRH antagonists MZ-4-71 and MZ-5-156 can inhibit the growth of SCLC and NSCLC. This new approach to the management of lung cancer merits further investigation.

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Spandidos Publications style Pinski J, Schally A, Jungwirth A, Groot K, Halmos G, Armatis P, Zarandi M and Vadillo-Buenfil M: Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). Int J Oncol 9: 1099-1105, 1996. APA Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P. ... Vadillo-Buenfil, M. (1996). Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). International Journal of Oncology, 9, 1099-1105. https://doi.org/10.3892/ijo.9.6.1099 MLA Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P., Zarandi, M., Vadillo-Buenfil, M."Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)". International Journal of Oncology 9.6 (1996): 1099-1105. Chicago Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P., Zarandi, M., Vadillo-Buenfil, M."Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)". International Journal of Oncology 9, no. 6 (1996): 1099-1105. https://doi.org/10.3892/ijo.9.6.1099 Copy and paste a formatted citation x Spandidos Publications style Pinski J, Schally A, Jungwirth A, Groot K, Halmos G, Armatis P, Zarandi M and Vadillo-Buenfil M: Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). Int J Oncol 9: 1099-1105, 1996. APA Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P. ... Vadillo-Buenfil, M. (1996). Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH). International Journal of Oncology, 9, 1099-1105. https://doi.org/10.3892/ijo.9.6.1099 MLA Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P., Zarandi, M., Vadillo-Buenfil, M."Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)". International Journal of Oncology 9.6 (1996): 1099-1105. Chicago Pinski, J., Schally, A., Jungwirth, A., Groot, K., Halmos, G., Armatis, P., Zarandi, M., Vadillo-Buenfil, M."Inhibition of growth of human small cell and non-small cell lung carcinomas by antagonists of growth hormone-releasing hormone (GH-RH)". International Journal of Oncology 9, no. 6 (1996): 1099-1105. https://doi.org/10.3892/ijo.9.6.1099 ↑ +

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