Jeffrey C. Hoch, Ph.D. - Faculty Directory › UConn Health
 | Jeffrey C. Hoch, PhDDirector, Gregory P. Mullen NMR Structural Biology FacilityProfessor, Department of Molecular Biology and Biophysics
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- Education & Training
- Committees & Organizations
- Research
- Lab Rotations
- Publications
- Presentations
| Degree | Institution | Major |
|---|---|---|
| BA | Boston University | Chemistry |
| MA | Harvard University | Physical Chemistry |
| PhD | Harvard University | Physical Chemistry |
| Name of Award/Honor | Awarding Organization |
|---|---|
| Election to Connecticut Academy of Science and Engineering (CASE) | Connecticut Academy of Science and Engineering |
| Henry C. Allen Lecture | Clark University, Worcester, MA |
| Council Representative 2001-2003 | Gordon Research Conferences |
| Merck Award, Department of Chemistry | Boston University |
| Society of Fellows and Scholars 1975-1976 | Boston University |
| Harold C. Case Scholar 1975-1978 | Boston University |
| Phi Beta Kappa, Epsilon of Massachusetts | Boston University |
| Name & Description | Category | Role | Type | Scope | Start Year | End Year |
|---|---|---|---|---|---|---|
| Journal of Biomolecuar NMR | Professional/Scientific Journal | Guest Editor | External | National | 2012 | 2013 |
| Dean’s Council | Education Committee | Representative | UConn Health | University | 2012 | 2013 |
| Gordon Research Conference on Computational Aspects of Biomolecular NMR, Barga, Italy | Other | Session Chair | External | International | 2011 | 2011 |
| Search Committee (Chair, Department of Cell Biology) | Advisory Committee | Member | UConn Health | University | 2010 | 2010 |
| NMR and Cancer, Farmington, CT | Other | Organizer | External | Local | 2010 | 2010 |
| Uconn Health Center Ad Hoc Appeals Committee | Advisory Committee | Member | UConn Health | University | 2010 | 2010 |
| NIH SEP Study Section, P41 | Study Section | Member | External | National | 2009 | |
| Department of Molecular, Microbial, & Structural Biology Faculty Search Committee | Advisory Committee | Member | UConn Health | University | 2009 | 2010 |
| UCHC Research Council | Advisory Committee | Member | UConn Health | University | 2009 | |
| Faculty/Staff Philanthropy Committee | Advisory Committee | Member | UConn Health | University | 2009 | |
| UConn Partnership for Excellence in Structural Biology | Education Committee | Director | UConn Health | University | 2009 | 2012 |
| Workshop on Sparse Data Collection and Processing, Asilomar, CA | Other | Organizer | External | National | 2008 | 2008 |
| NMR Bootcamp, Joint workshop with Canadian National NMR Facility | Other | Organizer | External | International | 2008 | 2008 |
| NMRDP International Summit | Other | Organizer | External | International | 2008 | 2008 |
| Molecular, Microbial, & Structural Biology Faculty Search Committee | Advisory Committee | Chair | UConn Health | University | 2008 | 2008 |
| Search Committee (Assistant Vice President of IT– Research Computing) | Advisory Committee | Member | UConn Health | University | 2008 | |
| UConn Partnership for Excellence in Structural Biology | Professional/Scientific Organization | Director | External | University | 2007 | |
| North Eastern Structure Symposium: Protein – Nucleic Acid Interactions, Storrs, CT | Other | Co-Chair | External | Regional | 2007 | 2007 |
| Biophysical Core Facility, Department of Molecular, Microbial, & Structural Biology | Advisory Committee | Director | UConn Health | University | 2007 | |
| UConn Partnership for Excellence in Structural Biology | Professional/Scientific Organization | Associate Director | External | University | 2006 | 2009 |
| Study Section Computational Biophysics (ZRG1) | Study Section | Ad Hoc Member | External | National | 2006 | |
| Advances in Biomolecular NMR Spectroscopy, Boston, MA | Professional/Scientific Organization | Co-Chair | External | Local | 2005 | |
| NIH Macromolecular Structure and Function Study Section | Study Section | Ad Hoc Member | External | National | 2005 | |
| Advances in Biomolecular NMR Spectroscopy, Boston, MA | Other | Co-Chair | External | National | 2005 | 2005 |
| Department of Molecular, Microbial, & Structural Biology, Symposium on Understanding Proteins: A Celebration of Contributions by Zheng-yu Peng | Other | Organizer | UConn Health | University | 2005 | 2005 |
| Molecular, Microbial, & Structural Biology Seminar | Other | Coordinator | UConn Health | University | 2005 | 2006 |
| Molecular, Microbial, & Structural Biology Faculty Search Committee | Advisory Committee | Member | UConn Health | University | 2005 | 2006 |
| New England Structural Symposium: NMR Perspectives on Biological Problems, Storrs, CT | Other | Co-Chair | External | Regional | 2004 | 2004 |
| UConn Health Center, Graduate Admissions Committee | Advisory Committee | Member | UConn Health | State | 2004 | |
| University of Connecticut, Executive Committee, Partnership for Excellence in Structural Biology | Education Committee | Member | UConn Health | University | 2004 | |
| Gregory P. Mullen NMR Structural Biology Facility, Department of Molecular, Microbial, & Structural Biology | Advisory Committee | Director | UConn Health | University | 2004 | |
| NIH Special Study Section, SBIR | Study Section | Chair | External | National | 2002 | |
| Council Representative, Gordon Research Conferences | Professional/Scientific Organization | Member | External | National | 2001 | 2003 |
| Advisory Board, BioMagResBank | Advisory Committee | Chair | External | Local | 2000 | 2004 |
| NIH Study Section Molecular and Cellular Biophysics (BBCA) | Study Section | Ad Hoc Member | External | National | 2000 | 2000 |
| Gordon Research Conference on Computational Aspects of Biomolecular NMR, Barga, Italy | Other | Chair | External | International | 1999 | 1999 |
| NIH Study Section Molecular and Cellular Biophysics | Study Section | Ad Hoc Member | External | National | 1996 | 1996 |
| Biohazard Safety Committee | Advisory Committee | Member | External | University | 1996 | 2000 |
| Advisory Board, Biological Magnetic Resonance Data Bank (BioMagResBank), Madison, Wisconsin | Advisory Committee | Member | External | State | 1994 | 2004 |
| NIH Special Study Section, Research Resource | Study Section | Member | External | National | 1994 | 1994 |
| NIH Study Section Molecular and Cellular Biophysics (BBCA) | Study Section | Ad Hoc Member | External | National | 1993 | 1993 |
| NIH Special Study Section, Program Project | Study Section | Member | External | National | 1992 | 1992 |
| NATO Advanced Research Workshop on Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy, Barga, Italy | Professional/Scientific Organization | Director | External | International | 1990 | |
| NIH Special Study Section, Shared Instrumentation | Study Section | Member | External | National | 1990 | 1990 |
| NATO Advanced Research Workshop on Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy, Barga, Italy | Other | Director | External | International | 1990 | 1990 |
| Rowland Institute, Library Committee | Advisory Committee | Member | External | University | 1989 | 2002 |
| Rowland Institute, Seminar Coordinator | Advisory Committee | Coordinator | External | University | 1985 | 2002 |
| Boston University, President’s Host (Student Representatives) | Education Committee | President’s Host | External | University | 1975 | 1976 |
| American Chemical Society | Professional/Scientific Organization | Member | External | National | ||
| Protein Society | Professional/Scientific Organization | Member | External | National | ||
| Journal of Molecular Biology | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of Magnetic Resonance | Professional/Scientific Journal | Reviewer | External | National | ||
| Biochemistry | Professional/Scientific Journal | Reviewer | External | National | ||
| Journal of the American Chemical Society | Professional/Scientific Journal | Reviewer | External | National | ||
| Biophysical Journal | Professional/Scientific Journal | Reviewer | External | National | ||
| Magnetic Resonance in Chemistry | Professional/Scientific Journal | Reviewer | External | National | ||
| Analytical Chemistry | Professional/Scientific Journal | Reviewer | External | National | ||
| National Science Foundation | Study Section | Grant Reviewer | External | National | ||
| Canadian National Research Council | Professional/Scientific Journal | Reviewer | External | International | ||
| National Science Foundation of Ireland | Professional/Scientific Journal | Reviewer | External | International | ||
| Proceedings of the National Academy of Sciences (USA) | Professional/Scientific Journal | Reviewer | External | National |
Our laboratory works on problems related to the physical basis for the biological activity of proteins. Broadly, this includes their structure, dynamics, stability, and interactions with other molecules. Some specific questions we are interested in include:
The relationship of protein dynamics and structure to biological activity. An example is the role of structure and dynamics in the interaction between prolactin and the prolactin receptor. Prolactin is involved in hundreds of biochemical pathways, and has been shown to be involved in cancer (expression levels of both prolactin and its receptor are elevated in some forms of breast cancer). Understanding the physical basis for prolactin-receptor interaction will aid the search for molecules that inhibit or enhance the signaling functions of prolactin.
In collaboration with Professor Choukri Ben-Mamoun we are investigating the structural biology of Plasmodium falciparum, the parasite that causes malaria. Despite the devastating impact of malaria on the developing world, cheap, safe, and effective treatments for malaria remain elusive. We are solving the structure of an enzyme that is essential for the survival of Plasmodium that has no homologs in mammals, and thus is potentially an important drug target. We plan to solve the structures of additional Plasmodium proteins.
We are collaborating with Professor Sandra Weller on structural studies of proteins from herpes simplex virus. These are particularly challenging proteins to investigate, but the insights that can be derived from these studies should shed light on mechanisms of essential processes such as DNA replication, and could guide the discovery of novel antiviral compunds.
We employ a variety of physical and computational methods, especially NMR, and also circular dichroism, fluoresence, and ultraviolet/visible absorption spectroscopies, water activity, differential and isothermal titration calorimietry, non-Fourier spectrum analysis, and molecular dynamics simulations.
The NMR resources at the UConn Health Center are outstanding, and include spectrometers operating at 400, 500, 600, and 800 MHz. The latter three instruments are equipped with state-of-the-art cryogenically cooled probes. Computational resources include a power 1000-node cluster shared with the Center for Cell Analysis and Modeling.
Not accepting lab rotation students at this time for Fall 2025/Spring 2026
Journal Articles
- Backbone resonance assignment of the pentraxin domain of the neuronal pentraxin receptor (NPTXR). Biomolecular NMR assignments 2026 Jan;20(1):10
- Scalable cyberinfrastructure for experimental NMR data. Scientific data 2025 Dec;
- Backbone assignment of the N-terminal domain of the A subunit of the Bacillus cereus GerI germinant receptor. Biomolecular NMR assignments 2025 Jan;
- PDB NextGen Archive: centralizing access to integrated annotations and enriched structural information by the Worldwide Protein Data Bank. Database : the journal of biological databases and curation 2024 May;2024
- Restraint validation of biomolecular structures determined by NMR in the Protein Data Bank. Structure (London, England : 1993) 2024 Mar;
- Community recommendations on cryoEM data archiving and validation. IUCrJ 2024 Mar;11(Pt 2):140-151
- Announcing the launch of Protein Data Bank China as an Associate Member of the Worldwide Protein Data Bank Partnership. Acta crystallographica. Section D, Structural biology 2023 Sep;79(Pt 9):792-795
- Crystal structure of the CoV-Y domain of SARS-CoV-2 nonstructural protein 3. Scientific reports 2023 Feb;13(1):2890
- Biological Magnetic Resonance Data Bank. Nucleic acids research 2023 Jan;51(D1):D368-D376
- Structure of the Sec14 domain of Kalirin reveals a distinct class of lipid-binding module in RhoGEFs. Nature communications 2023 Jan;14(1):96
- Comprehensive Fragment Screening of the SARS-CoV-2 Proteome Explores Novel Chemical Space for Drug Development. Angewandte Chemie (International ed. in English) 2022 Sep;e202205858
- Architecture of the two metal-binding sites in prolactin. Biophysical journal 2022 Feb;
- NUScon: a community-driven platform for quantitative evaluation of nonuniform sampling in NMR Magnetic Resonance 2021 Nov;2843-861
- Backbone and Ile, Leu, Val methyl group resonance assignment of CoV-Y domain of SARS-CoV-2 non-structural protein 3. Biomolecular NMR assignments 2021 Nov;
- Merging NMR Data and Computation Facilitates Data-Centered Research. Frontiers in molecular biosciences 2021 Nov;8817175
- Anomalous amide proton chemical shifts as signatures of hydrogen bonding to aromatic sidechains Magnetic Resonance 2021 Oct;2(2):765-775
- Enhanced validation of small-molecule ligands and carbohydrates in the Protein Data Bank. Structure (London, England : 1993) 2021 Apr;29(4):393-400.e1
- Large-Scale Recombinant Production of the SARS-CoV-2 Proteome for High-Throughput and Structural Biology Applications. Frontiers in molecular biosciences 2021 Jan;8653148
- BioMagResBank (BMRB) as a Resource for Structural Biology. Methods in molecular biology (Clifton, N.J.) 2020 Jan;2112187-218
- The influence of the probability density function on spectral quality in nonuniformly sampled multidimensional NMR. Journal of magnetic resonance (San Diego, Calif. : 1997) 2019 Dec;311106671
- Federating Structural Models and Data: Outcomes from A Workshop on Archiving Integrative Structures. Structure (London, England : 1993) 2019 Dec;27(12):1745-1759
- If machines can learn, who needs scientists? Journal of magnetic resonance (San Diego, Calif. : 1997) 2019 Jul;
- Announcing mandatory submission of PDBx/mmCIF format files for crystallographic depositions to the Protein Data Bank (PDB). Acta crystallographica. Section D, Structural biology 2019 Apr;75(Pt 4):451-454
- Concomitant disorder and high affinity zinc binding in the hZIP4 intracellular loop. Protein science : a publication of the Protein Society 2019 Feb;
- NMR-STAR: comprehensive ontology for representing, archiving and exchanging data from nuclear magnetic resonance spectroscopic experiments. Journal of biomolecular NMR 2018 Dec;
- Nonuniform sampling in multidimensional NMR for improving spectral sensitivity. Methods (San Diego, Calif.) 2018 Mar;138-13962-68
- Preliminary Comparison of Non-Fourier Methods for Spectrum Analysis of Nonuniformly Sampled NMR Data. Nist.gov Publications 2018 Jan;
- Practical Nonuniform Sampling and Non-Fourier Spectral Reconstruction for Multidimensional NMR. Methods in molecular biology (Clifton, N.J.) 2018 Jan;1688341-352
- Robust and transferable quantification of NMR spectral quality using IROC analysis. Journal of magnetic resonance (San Diego, Calif. : 1997) 2017 Oct;28537-46
- Beyond Fourier. Journal of magnetic resonance (San Diego, Calif. : 1997) 2017 Oct;283117-123
- NMRbox: A Resource for Biomolecular NMR Computation. Biophysical journal 2017 Apr;112(8):1529-1534
- A new approach to compressed sensing for NMR. Magnetic resonance in chemistry : MRC 2015 Aug;53(11):908-12
- CONNJUR R: an annotation strategy for fostering reproducibility in bio-NMR-protein spectral assignment. Journal of biomolecular NMR 2015 Aug;63(2):141-50
- Sensitivity of nonuniform sampling NMR. The journal of physical chemistry. B 2015 Jun;119(22):6502-15
- Nonuniform sampling of hypercomplex multidimensional NMR experiments: Dimensionality, quadrature phase and randomization. Journal of magnetic resonance (San Diego, Calif. : 1997) 2015 May;254121-30
- The indelible mark of computation on bio-NMR. Journal of biomolecular NMR 2014 Apr;58(4):231-2
- Nonuniform sampling and maximum entropy reconstruction in multidimensional NMR. Accounts of chemical research 2014 Jan;47(2):708-17
- (1)H, (13)C, and (15)N chemical shift assignments for PfPMT, a phosphoethanolamine methyltransferase from Plasmodium falciparum. Biomolecular NMR assignments 2013 Apr;7(1):17-20
- Formalism for hypercomplex multidimensional NMR employing partial-component subsampling. Journal of magnetic resonance (San Diego, Calif. : 1997) 2013 Feb;22720-4
- A time-saving strategy for MAS NMR spectroscopy by combining nonuniform sampling and paramagnetic relaxation assisted condensed data collection. The journal of physical chemistry. B 2012 Nov;116(46):13585-96
- Sparse sampling methods in multidimensional NMR. Physical chemistry chemical physics : PCCP 2012 Aug;14(31):10835-43
- Enhanced sensitivity by nonuniform sampling enables multidimensional MAS NMR spectroscopy of protein assemblies. The journal of physical chemistry. B 2012 Jun;116(25):7416-27
- N-terminal Dbl domain of the RhoGEF, Kalirin. Journal of biomolecular NMR 2012 Mar;52(3):269-76
- Data sampling in multidimensional NMR: fundamentals and strategies. Topics in current chemistry 2012 Jan;31649-77
- Random phase detection in multidimensional NMR. Proceedings of the National Academy of Sciences of the United States of America 2011 Oct;108(40):16640-4
- Knowledge-based nonuniform sampling in multidimensional NMR. Journal of biomolecular NMR 2011 Jul;50(3):247-62
- Phosphoethanolamine methyltransferases in phosphocholine biosynthesis: functions and potential for antiparasite therapy. FEMS microbiology reviews 2011 Jul;35(4):609-19
- A non-uniformly sampled 4D HCC(CO)NH-TOCSY experiment processed using maximum entropy for rapid protein sidechain assignment. Journal of magnetic resonance (San Diego, Calif. : 1997) 2010 May;204(1):160-4
- Identification of inhibitors of Plasmodium falciparum phosphoethanolamine methyltransferase using an enzyme-coupled transmethylation assay. BMC biochemistry 2010 Jan;114
- Nonuniform sampling and spectral aliasing. Journal of magnetic resonance (San Diego, Calif. : 1997) 2009 Jul;199(1):88-93
- Randomization improves sparse sampling in multidimensional NMR. Journal of magnetic resonance (San Diego, Calif. : 1997) 2008 Aug;193(2):317-20
- Biochemical and genetic analysis of the phosphoethanolamine methyltransferase of the human malaria parasite Plasmodium falciparum. The Journal of biological chemistry 2008 Mar;283(12):7894-900
- Automatic maximum entropy spectral reconstruction in NMR. Journal of biomolecular NMR 2007 Oct;39(2):133-9
- NMR data processing using iterative thresholding and minimum l(1)-norm reconstruction. Journal of magnetic resonance (San Diego, Calif. : 1997) 2007 Oct;188(2):295-300
- Spectral reconstruction methods in fast NMR: reduced dimensionality, random sampling and maximum entropy. Journal of magnetic resonance (San Diego, Calif. : 1997) 2006 Sep;182(1):96-105
- Three-dimensional 13C-detected CH3-TOCSY using selectively protonated proteins: facile methyl resonance assignment and protein structure determination. Journal of the American Chemical Society 2006 Jul;128(28):9119-28
- Non-uniformly sampled double-TROSY hNcaNH experiments for NMR sequential assignments of large proteins. Journal of the American Chemical Society 2006 May;128(17):5757-63
- Fast assignment of 15N-HSQC peaks using high-resolution 3D HNcocaNH experiments with non-uniform sampling. Journal of biomolecular NMR 2005 Sep;33(1):43-50
- Solution structure of human prolactin. Journal of molecular biology 2005 Aug;351(4):810-23
- High-resolution aliphatic side-chain assignments in 3D HCcoNH experiments with joint H-C evolution and non-uniform sampling. Journal of biomolecular NMR 2005 May;32(1):55-60
- Optimization of 13C direct detection NMR methods. Journal of biomolecular NMR 2004 Oct;30(2):175-9
- Accelerated acquisition of high resolution triple-resonance spectra using non-uniform sampling and maximum entropy reconstruction. Journal of magnetic resonance (San Diego, Calif. : 1997) 2004 Sep;170(1):15-21
- Resolution and sensitivity of high field nuclear magnetic resonance spectroscopy. Journal of biomolecular NMR 2004 Sep;30(1):1-10
- Molecular dynamics of the long neurotoxin LSIII. Biochemistry 2003 Dec;42(49):14443-51
- Multiple-quantum magic-angle spinning spectroscopy using nonlinear sampling. Journal of magnetic resonance (San Diego, Calif. : 1997) 2003 Mar;161(1):43-55
- De novo backbone and sequence design of an idealized alpha/beta-barrel protein: evidence of stable tertiary structure. Journal of molecular biology 2003 Jan;325(1):163-74
- Elimination of 13C(alpha) Splitting in Protein NMR Spectra by Deconvolution with Maximum Entropy Reconstruction J. Am. Chem. Soc 2003 Jan;125(9):2382-2383
- Modern spectrum analysis in multidimensional NMR spectroscopy: comparison of linear-prediction extrapolation and maximum-entropy reconstruction. Journal of the American Chemical Society 2002 Mar;124(9):1982-93
- Maximum entropy reconstruction, spectrum analysis and deconvolution in multidimensional nuclear magnetic resonance. Methods in enzymology 2001 Jan;338159-78
- New Carbon-Detected Protein NMR Experiments Using CryoProbes Journal of the American Chemical Society 2000 Jan;1223554-3555
- Distributed parallel processing for multidimensional maximum entropy reconstruction. Journal of magnetic resonance (San Diego, Calif. : 1997) 1998 Sep;134(1):161-3
- Quantification of maximum-entropy spectrum reconstructions. Journal of magnetic resonance (San Diego, Calif. : 1997) 1997 Apr;125(2):332-9
- Solution structure of LSIII, a long neurotoxin from the venom of Laticauda semifasciata. Biochemistry 1996 Jan;35(2):418-26
- Improved resolution in triple-resonance spectra by nonlinear sampling in the constant-time domain. Journal of biomolecular NMR 1994 Jul;4(4):483-90
- Application of nonlinear sampling schemes to COSY-type spectra. Journal of biomolecular NMR 1993 Sep;3(5):569-76
- Holographic Methods in X-ray Crystallography III. First Numerical Results Acta Cryst 1993 Jan;A49866-871
- A method for determining overall protein fold from NMR distance restraints J Biomol NMR 1992 Jan;2535-543
- A New, Storage-efficient Algorithm for Maximum Entropy Spectrum Reconstruction Journal of Magnetic Resonance 1992 Jan;97255-270
- Characterization of the Structural Properties of α1B, a Peptide Designed to Form a Four-Helix Bundle J Amer Chem Soc 1992 Jan;144331-337
- Maximum Entropy and The Nearly Black Object J R Statist Soc B 1992 Jan;5441-81
- Computer-Aided Analysis of Protein NMR Spectra Current Opinion in Structural Biology 1991 Jan;161036-1041
- Photochemical Oxidation of Tryptophan Residues During Photo-CIDNP Experiments J Magn Reson 1991 Jan;95165-173
- Does the maximum entropy method improve sensitivity? Proc Natl Acad Sci U S A 1990 Jan;87(13):5066-5068
- Maximum Entropy Reconstruction of Complex (Phase-Sensitive) Spectra Journal of Magnetic Resonance 1990 Jan;86(2):236-246
- Modern Spectrum Analysis in NMR: Alternatives to FT Meth Enzym 1989 Jan;176216-241
- Structural Determination of Biological Macromolecules by Three-Dimensional NMR Physics Today 1989 Jan;42(S19):
- Interpretation of Ring-Current Shifts in Proteins: Application to Phage λ Repressor J Magn Reson 1987 Jan;72324-333
- Symmetry Recognition Applied to Two-Dimensional NMR Data Carlsberg Res Commun 1987 Jan;52111-122
- Determination of the chromosomal locations of four Bacillus subtilis genes which code for a family of small, acid-soluble spore proteins. Journal of bacteriology 1986 May;166(2):412-6
- Maximum Entropy Signal Processing of Two Dimensional NMR Data J Magn Reson 1985 Jan;64436-440
- Quantitative Measurement Using Pure-Phase Two-Dimensional Exchange Spectroscopy J. Magn. Reson 1985 Jan;64199-206
- Vicinal Coupling Constants and Protein Dynamics Biochemistry 1985 Jan;243831-3841
- Chemical Shifts of Aromatic Protons in Protein NMR Spectra FEBS Lett 1983 Jan;159132-136
- Fluctuations and averaging of proton chemical shifts in the bovine pancreatic trypsin inhibitor. Biochemistry 1982 Mar;21(6):1118-25
- Structures and Dynamics of Proteins by Proton NMR. Application of Nuclear Overhauser Effects to Lysozyme Biomolecular Stereodynamics 1981 Jan;2237-253
- A structural study of the hydrophobic box region of lysozyme in solution using nuclear Overhauser effects. Biochemistry 1980 Jun;19(12):2597-607
- Conformations and Conformational Dynamics of Proteins in Solution Studied by Nuclear Magnetic Double Resonance Biophys J 1980 Jan;32(13):625-628
- Kinetics of Chloride Substitution into Bis(oxalato)platinate(II) Ion Inorg Chem 1979 Jan;18886-887
- Investigation of the Structure of the Reaction Center in Photosynthetic Systems by Optical Detection of Triplet State Magnetic Resonance Chem Phys Lett 1977 Jan;45523-528
Books
- NMR Data Processing 1996 Jan;
- Computational Aspects of the Study of Biological Macromolecules by Nuclear Magnetic Resonance Spectroscopy 1991 Jan;
Book Sections
- Maximum Entropy Reconstruction Encyclopedia of Biophysics 2012 Jan;
- Maximum Entropy: Multidimensional Methods Encyclopedia of Magnetic Resonance 2009 Jan;
- Nonuniform sampling in biomolecular NMR Modern Magnetic Resonance 2006 Jan;1287-1293
- Bayesian Restraint Potentials for Consistent Inference of Biomolecular Structure from NMR Data Structure, Dynamics and Function of Biological Macromolecules and Assemblies 2005 Jan;
- Signatures and Consequences of Hydrophobic Strain in Globular Proteins Dynamics, Structure, and Function of Biological Macromolecules 2001 Jan;
- Fitting Protein Structures to Experimental Data: Lessons from Before Your Mother Was Born Protein Dynamics, Function, and Design 1998 Jan;
- Maximum Entropy Reconstruction in NMR Encyclopedia of NMR 1996 Jan;
- Solution Structure of the Long Neurotoxin LSIII, With Possible Implications for Binding to the Acetylcholine Receptor Dynamics and the Problem of Recognition in Biological Macromolecules 1996 Jan;
- Bons Baisers de Boston Plaisirs de la table 1993 Jan;30-31
- An Amateur Looks at Error Analysis in the Determination of Protein Structure by NMR Computational Aspects of the Study of Biological Macromolecules by NMR Spectroscopy 1991 Jan;253-267
- Computer Assisted Assignment of Two-Dimensional NMR Spectra of Proteins Frontiers of NMR in Molecular Biology 1990 Jan;167-175
Letters
- Another barrier to reproducibility Science 2017 Jan;354(6317):1240-1241
- New NMR machines are set to boost biomedical potential. Nature 2010 Feb;463(7284):1018
- An automated tool for maximum entropy reconstruction of biomolecular NMR spectra. Nature methods 2007 Jun;4(6):467-8
Notes
- Comment on "magnetic resonance spectroscopy identifies neural progenitor cells in the live human brain". Science (New York, N.Y.) 2008 Aug;321(5889):640
- Local knowledge helps determine protein structures. Proceedings of the National Academy of Sciences of the United States of America 2008 Mar;105(12):4533-4
Reviews
- Securing the Future of NMR Metabolomics Reproducibility: A Call for Standardized Reporting. Analytical chemistry 2025 Sep;97(38):20655-20666
- Perspective: use and reuse of NMR-based metabolomics data: what works and what remains challenging. Metabolomics : Official journal of the Metabolomic Society 2024 Mar;20(2):41
- Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions. Nature methods 2023 Jul;
- NMR and Metabolomics-A Roadmap for the Future. Metabolites 2022 Jul;12(8):
- Nonuniform sampling and maximum entropy reconstruction applied to the accurate measurement of residual dipolar couplings. Journal of magnetic resonance (San Diego, Calif. : 1997) 2007 Jun;186(2):201-11
| Title or Abstract | Type | Sponsor/Event | Date/Year | Location |
|---|---|---|---|---|
| Non-Fourier Methods of Signal Processing; Fundamentals of Uniform and Nonuniform Sampling | Lecture | Gregory P. Mullen NMR Structural Biology Facility | 2012 | Farmington, CT |
| NMR in Biology: An Evergreen | Lecture | University of Massachusetts Boston | 2012 | Boston, MA |
| ABC's of NUS | Lecture | Experimental NMR Conference | 2012 | Miami |
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