2 thg 6, 2022 · K103N is a nonpolymorphic mutation selected in patients receiving NVP and EFV (22,37,38,23). It reduces NVP and EFV susceptibility by about ... L100I · K103N/S/H/T/R/Q/E · E138K/A/G/Q/R · V179D/E/F/I/L/T
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This may be facilitated by high viral loads and low CD4+ T cell counts, as well as by the long half-life of nevirapine. The K103N mutation is the major ...
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21 thg 11, 2014 · In a research on nevirapine-experienced individuals, the frequencies of these mutations were 43%, 46% and 26% respectively [31]. Among the three ...
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The most common drug resistance mutation was K103N (72.7%), which was found among eight individuals (6.1%), while the prevalence of TDR for NRTI, nonnucleoside ...
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Download scientific diagram | The K103N mutation in phylogenetic analyses of HIV-1 subtype B pol sequences. The reliability of tree topologies was assessed ...
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This research focused on isolating the potential specific DNA aptamers against K103N/Y181C double mutant HIV-1 RT. Five DNA aptamers showed low IC50 values ...
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K103N (Substitution - Missense, position 103, K➞N). CDS mutation. c.309G>T (Substitution, position 309, G➞T). SNP: No; Nucleotides inserted: n/a ...
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17 thg 2, 2016 · Crystal Structure of K103N/Y181C Mutant HIV-1 Reverse Transcriptase (RT) in Complex with IDX899.
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Virus: HIV-1 variant, infectious recombinant virus with specific mutations in the RT gene as indicated. These mutations confer resistance to specific HIV RT ...
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The K103N mutation arises quickly upon inadequate viral suppression. It has low effect on viral fitness and is maintained for long periods of time after ...
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The K103N NVP resistance mutation was detected 6 weeks after NVP administration in three (20%) out of 15 women (95% confidence interval, 0–40%).
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8 thg 8, 2019 · Find information on the incidence of K103N in patients taking INTELENCE. Learn more about the treatment of HIV-1 infection with INTELENCE.
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Regardless of advances in anti-HIV therapy, HIV infection remains an immense challenge due to the rapid onset of mutation instigating drug resistance.
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9 thg 4, 2018 · K103N occurred at the highest rate, accounting for 22% (6/27), followed by P225H (7%) and Y188L (4%). Neither of the two groups showed any major ...
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