| Entry | |
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| Name | Uropathogenic Escherichia coli (UPEC) infection |
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| Description | Uropathogenic Escherichia coli (UPEC) infection is a prevalent infectious disease with potentially severe complications. UPEC, the most common etiological agent of community-acquired urinary tract infections (UTIs), accounts for >80% of UTI infections worldwide. Once inside the urinary tract, UPEC preferentially colonizes the bladder and causes cystitis, but can also ascend through the ureters into the kidneys, causing pyelonephritis. |
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| Category | Bacterial infectious disease |
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| Brite | Human diseases in ICD-11 classification [BR:br08403] 16 Diseases of the genitourinary system Diseases of the urinary system Certain specified diseases of urinary system GC08 Urinary tract infection, site not specified H00279 Uropathogenic Escherichia coli (UPEC) infection Genome-based classification of infectious diseases [BR:br08401] Bacterial infections Infections caused by enterobacteria H00279 Uropathogenic Escherichia coli (UPEC) infection BRITE hierarchy |
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| Pathogen | Escherichia coli (UPEC) [GN:ecp ena ecos eum ect eci ecc ecoj]pore-forming toxin [KO:K11003 K11004 K11005] |
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| Other DBs | |
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| Reference | PMID:9551528 |
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| Authors | Matsumoto T |
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| Title | [Virulence factors and host responses in urinary tract infections]. |
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| Journal | J UOEH 20:45-60 (1998)DOI:10.7888/juoeh.20.45 |
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| Reference | PMID:16100859 |
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| Authors | Mehnert-Kay SA |
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| Title | Diagnosis and management of uncomplicated urinary tract infections. |
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| Journal | Am Fam Physician 72:451-6 (2005) |
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| Reference | PMID:16406777 |
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| Authors | Svanborg C, Bergsten G, Fischer H, Godaly G, Gustafsson M, Karpman D, Lundstedt AC, Ragnarsdottir B, Svensson M, Wullt B |
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| Title | Uropathogenic Escherichia coli as a model of host-parasite interaction. |
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| Journal | Curr Opin Microbiol 9:33-9 (2006)DOI:10.1016/j.mib.2005.12.012 |
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| Reference | PMID:17458672 |
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| Authors | Yamamoto S |
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| Title | Molecular epidemiology of uropathogenic Escherichia coli. |
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| Journal | J Infect Chemother 13:68-73 (2007)DOI:10.1007/s10156-007-0506-y |
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| Reference | PMID:18482721 |
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| Authors | Wiles TJ, Kulesus RR, Mulvey MA |
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| Title | Origins and virulence mechanisms of uropathogenic Escherichia coli. |
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| Journal | Exp Mol Pathol 85:11-9 (2008)DOI:10.1016/j.yexmp.2008.03.007 |
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| Reference | PMID:18616559 |
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| Authors | Dhakal BK, Kulesus RR, Mulvey MA |
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| Title | Mechanisms and consequences of bladder cell invasion by uropathogenic Escherichia coli. |
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| Journal | Eur J Clin Invest 38 Suppl 2:2-11 (2008)DOI:10.1111/j.1365-2362.2008.01986.x |
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