 | DRUG: Dovitinib lactate | Help |
| Entry | |
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| Name | Dovitinib lactate (USAN);Dovitinib lactate hydrate (JAN) |
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| Formula | C21H21FN6O. C3H6O3. H2O |
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| Exact mass | 500.2183 |
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| Mol weight | 500.52 |
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| Structure |  Mol fileKCF fileDB search |
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| Class | Antineoplastic DG01918 Tyrosine kinase inhibitor DG01917 Receptor tyrosine kinase inhibitor |
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| Efficacy | Antineoplastic, Receptor tyrosine kinase inhibitor |
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| Target | FLT3 (CD135) [HSA:2322] [KO:K05092]PDGFRB [HSA:5159] [KO:K05089]KIT (CD117) [HSA:3815] [KO:K05091]FGFR3 (CD333) [HSA:2261] [KO:K05094]VEGFR1 (FLT1) [HSA:2321] [KO:K05096]VEGFR2 (KDR) [HSA:3791] [KO:K05098]VEGFR3 (FLT4) [HSA:2324] [KO:K05097] |
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| Pathway | | hsa04010 | MAPK signaling pathway |
| hsa04151 | PI3K-Akt signaling pathway |
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| Interaction | DDI search |
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| Brite | Drug groups [BR:br08330] Antineoplastic DG01918 Tyrosine kinase inhibitor DG01917 Receptor tyrosine kinase inhibitor D08907 Dovitinib lactate Target-based classification of drugs [BR:br08310] Protein kinases Receptor tyrosine kinases (RTK) PDGFR family PDGFRB D08907 Dovitinib lactate (USAN) KIT (CD117) D08907 Dovitinib lactate (USAN) FLT3 (CD135) D08907 Dovitinib lactate (USAN) FGFR family FGFR3 (CD333) D08907 Dovitinib lactate (USAN) VEGFR family VEGFR1 (FLT1) D08907 Dovitinib lactate (USAN) VEGFR2 (KDR) D08907 Dovitinib lactate (USAN) VEGFR3 (FLT4) D08907 Dovitinib lactate (USAN) BRITE hierarchy |
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| Other DBs | |
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| KCF data | ShowATOM 36 1 C8x C 9.5696 -19.3790 2 C8x C 9.5696 -20.7836 3 C8x C 10.7860 -21.4858 4 C8y C 12.0024 -20.7836 5 C8y C 12.0024 -19.3790 6 C8y C 10.7860 -18.6767 7 N4x N 13.2188 -21.4858 8 C8y C 14.4351 -20.7836 9 C8y C 14.4351 -19.3790 10 C8y C 13.2188 -18.6767 11 X F 10.7860 -17.2723 12 N1a N 13.2188 -17.2721 13 C8y C 15.6367 -18.6852 14 N5x N 16.8937 -19.2448 15 C8y C 17.8145 -18.2221 16 C8y C 17.1265 -17.0304 17 N4x N 15.7804 -17.3166 18 C8x C 19.2191 -18.2221 19 C8x C 19.9214 -17.0058 20 C8y C 19.2333 -15.8140 21 C8x C 17.8287 -15.8140 22 O5x O 15.6367 -21.4773 23 N1y N 19.9494 -14.5729 24 C1x C 21.3677 -14.5722 25 C1x C 22.0694 -13.3556 26 N1y N 21.3665 -12.1395 27 C1x C 19.9483 -12.1401 28 C1x C 19.2465 -13.3569 29 C1a C 22.0661 -10.9266 30 C6a C 23.2642 -19.0278 31 O6a O 24.4805 -19.7301 32 C1c C 22.0478 -19.7301 33 O1a O 20.8484 -19.0375 34 C1a C 22.0477 -21.1345 35 O6a O 23.2642 -17.6233 36 O0 O 27.6184 -18.1149 BOND 38 1 1 2 1 2 2 3 2 3 3 4 1 4 4 5 2 5 5 6 1 6 1 6 2 7 4 7 1 8 7 8 1 9 8 9 1 10 9 10 2 11 5 10 1 12 6 11 1 13 10 12 1 14 9 13 1 15 13 14 2 16 14 15 1 17 15 16 1 18 16 17 1 19 13 17 1 20 15 18 2 21 18 19 1 22 19 20 2 23 20 21 1 24 16 21 2 25 8 22 2 26 20 23 1 27 23 24 1 28 24 25 1 29 25 26 1 30 26 27 1 31 27 28 1 32 23 28 1 33 26 29 1 34 30 31 1 35 30 32 1 36 32 33 1 37 32 34 1 38 30 35 2 |
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