 | DRUG: Ephedrine hydrochloride | Help |
| Entry | |
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| Name | Ephedrine hydrochloride (JP18/USP) |
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| Formula | C10H15NO. HCl |
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| Exact mass | 201.0920 |
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| Mol weight | 201.69 |
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| Structure |  Mol fileKCF fileDB search |
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| Simcomp | Neighbor |
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| Class | Cardiovascular agent DG01703 Cardiotonic DG01702 Phenethylamine cardiotonic DG01456 Adrenergic receptor agonist Respiratory system agent DG03282 Ephedrine-containing preparation |
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| Remark | | Therapeutic category: | 2118 2221 |
| ATC code: | C01CA26 R01AA03 R01AB05 R03CA02 S01FB02 |
| Chemical structure group: | DG00227 |
| Product (DG00227): | D01386<JP> D04018<US> |
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| Efficacy | Antitussive, Bronchodilator, Adrenergic receptor agonist |
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| Comment | Phenethylamine derivative |
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| Target | ADRA1 [HSA:148 147 146] [KO:K04135 K04136 K04137]ADRA2 [HSA:150 151 152] [KO:K04138 K04139 K04140]ADRB [HSA:153 154 155] [KO:K04141 K04142 K04143] |
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| Pathway | | hsa04020 | Calcium signaling pathway |
| hsa04080 | Neuroactive ligand-receptor interaction |
| hsa04261 | Adrenergic signaling in cardiomyocytes |
| hsa04270 | Vascular smooth muscle contraction |
| hsa04970 | Salivary secretion |
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| Interaction | DDI search |
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| Brite | Anatomical Therapeutic Chemical (ATC) classification [BR:br08303] C CARDIOVASCULAR SYSTEM C01 CARDIAC THERAPY C01C CARDIAC STIMULANTS EXCL. CARDIAC GLYCOSIDES C01CA Adrenergic and dopaminergic agents C01CA26 Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) <JP> R RESPIRATORY SYSTEM R01 NASAL PREPARATIONS R01A DECONGESTANTS AND OTHER NASAL PREPARATIONS FOR TOPICAL USE R01AA Sympathomimetics, plain R01AA03 Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) <JP> R01AB Sympathomimetics, combinations excl. corticosteroids R01AB05 Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) <JP> R03 DRUGS FOR OBSTRUCTIVE AIRWAY DISEASES R03C ADRENERGICS FOR SYSTEMIC USE R03CA Alpha- and beta-adrenoreceptor agonists R03CA02 Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) <JP> S SENSORY ORGANS S01 OPHTHALMOLOGICALS S01F MYDRIATICS AND CYCLOPLEGICS S01FB Sympathomimetics excl. antiglaucoma preparations S01FB02 Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) <JP> Therapeutic category of drugs in Japan [BR:br08301] 2 Agents affecting individual organs 21 Cardiovascular agents 211 Cardiotonics 2118 Alkaloids D01386 Ephedrine hydrochloride (JP18/USP) 22 Respiratory organ agents 222 Antitussives 2221 Ephedrines and Ephedra herbs D01386 Ephedrine hydrochloride (JP18/USP) Risk category of Japanese OTC drugs [BR:br08312] Second-class OTC drugs Inorganic and organic chemicals Ephedrine D01386 Ephedrine hydrochloride (JP18/USP) Drug groups [BR:br08330] Cardiovascular agent DG01703 Cardiotonic DG01702 Phenethylamine cardiotonic DG00227 Ephedrine D01386 Ephedrine hydrochloride DG01456 Adrenergic receptor agonist DG00227 Ephedrine D01386 Ephedrine hydrochloride Respiratory system agent DG03282 Ephedrine-containing preparation DG00227 Ephedrine D01386 Ephedrine hydrochloride Target-based classification of drugs [BR:br08310] G Protein-coupled receptors Rhodopsin family Adrenaline ADRA1 D01386 Ephedrine hydrochloride (JP18/USP) <JP> ADRA2 D01386 Ephedrine hydrochloride (JP18/USP) <JP> ADRB D01386 Ephedrine hydrochloride (JP18/USP) <JP> Drugs listed in the Japanese Pharmacopoeia [BR:br08311] Chemicals D01386 Ephedrine hydrochloride D01386 Ephedrine hydrochloride tablets D01386 10% Ephedrine hydrochloride powder D01386 Ephedrine hydrochloride injection Rx-to-OTC switch list in the USA [br08315.html] D01386 Drug groups [BR:br08330] Cardiovascular agent DG01703 Cardiotonic DG01702 Phenethylamine cardiotonic DG00227 Ephedrine DG01456 Adrenergic receptor agonist DG00227 Ephedrine Respiratory system agent DG03282 Ephedrine-containing preparation DG00227 Ephedrine BRITE hierarchy |
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| Other DBs | |
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| KCF data | ShowATOM 13 1 C8x C 17.0325 -17.0009 2 C8x C 17.0325 -18.4031 3 C8x C 18.2497 -19.1041 4 C8x C 19.4598 -18.4031 5 C8y C 19.4598 -17.0009 6 C8x C 18.2497 -16.2999 7 C1c C 20.6653 -16.2999 8 C1c C 21.8762 -16.9938 9 N1b N 23.0872 -16.2927 10 C1a C 24.2981 -16.9867 11 O1a O 20.6609 -14.8977 12 C1a C 21.8793 -18.3959 13 X Cl 29.1200 -17.5000 BOND 12 1 6 1 1 2 5 7 1 3 1 2 2 4 7 8 1 5 2 3 1 6 8 9 1 7 3 4 2 8 9 10 1 9 4 5 1 10 7 11 1 #Up 11 5 6 2 12 8 12 1 #Up |
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