KRAS K147N [plasma Membrane] - Reactome

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KRAS K147N [plasma membrane]

Stable Identifier R-HSA-9651177 Type Protein [EntityWithAccessionedSequence] Species Homo sapiens Compartment plasma membrane Locations in the PathwayBrowser Expand all Disease (Homo sapiens)

• • Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
    • Oncogenic MAPK signaling (Homo sapiens)
      • Paradoxical activation of RAF signaling by kinase inactive BRAF (Homo sapiens)
        • Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants (Homo sapiens)
          • RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
        • Dissociation of paradoxically activated RAS:BRAF complexes (Homo sapiens)
          • RAS:GTP:inactive p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
        • Inactive BRAF mutants bind mutant RAS:GTP (Homo sapiens)
          • RAS mutants:GTP [plasma membrane] (Homo sapiens)
            • RAS mutants [plasma membrane] (Homo sapiens)
              • RAS GEF mutants [plasma membrane] (Homo sapiens)
                • KRAS K147N [plasma membrane] (Homo sapiens)
          • chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
        • Inactive BRAF mutants:mutant RAS:GTP bind RAF1 (Homo sapiens)
          • chemically or genetically inactive BRAF mutants:mutant RAS:GTP [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
          • mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
        • RAF is paradoxically phosphorylated downstream of kinase-inactive RAF (Homo sapiens)
          • mutant RAS:inactive BRAF:RAF1 [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
          • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
        • RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
          • RAS:GTP: inactive p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
        • RAS:GTP:p-RAF complexes paradoxically bind MAP2Ks and MAPKs (Homo sapiens)
          • RAS:GTP:inactive p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
            • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • mutant RAS:inactive BRAF:p-S338,T491,S494,S729 RAF1 [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
      • Signaling by RAS mutants (Homo sapiens)
        • Signaling downstream of RAS mutants (Homo sapiens)
          • Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS (Homo sapiens)
            • mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
            • mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
          • Dissociation of oncogenic RAS:RAF complex (Homo sapiens)
            • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
            • mutant RAS:GTP:p-RAF:p-2S MAP2Ks:p-T,Y MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
          • Homo- or heterodimerization of RAF downstream of mutant RAS (Homo sapiens)
            • RAS mutants:GTP:RAF [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • Mutant RAS:p-RAF complexes bind MAP2Ks and MAPKs (Homo sapiens)
            • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
            • mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
          • Mutant RAS:p-RAF complexes phosphorylate MAP2Ks (Homo sapiens)
            • mutant RAS:GTP:p-RAF:MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
            • mutant RAS:GTP:p-RAF:p-2S MAP2Ks:MAPKs:scaffold proteins [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
                • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                  • RAS mutants [plasma membrane] (Homo sapiens)
                    • RAS GEF mutants [plasma membrane] (Homo sapiens)
                      • KRAS K147N [plasma membrane] (Homo sapiens)
          • RAF is phosphorylated downstream of oncogenic RAS (Homo sapiens)
            • RAS mutants:GTP:RAF homo/heterodimer [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP:p-RAF homo/heterodimer [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)
          • RAS mutants bind inactive RAF (Homo sapiens)
            • RAS mutants:GTP [plasma membrane] (Homo sapiens)
              • RAS mutants [plasma membrane] (Homo sapiens)
                • RAS GEF mutants [plasma membrane] (Homo sapiens)
                  • KRAS K147N [plasma membrane] (Homo sapiens)
            • RAS mutants:GTP:RAF [plasma membrane] (Homo sapiens)
              • RAS mutants:GTP [plasma membrane] (Homo sapiens)
                • RAS mutants [plasma membrane] (Homo sapiens)
                  • RAS GEF mutants [plasma membrane] (Homo sapiens)
                    • KRAS K147N [plasma membrane] (Homo sapiens)

External Reference Information External Reference UniProt:P01116 KRAS Gene Names KRAS, KRAS2, RASK2 Chain chain:1-186, initiator methionine:1, chain:2-186, propeptide:187-189 Reference Genes BioGPS Gene:3845 KRAS COSMIC (genes):KRAS KRAS CTD Gene:3845 KRAS dbSNP Gene:3845 KRAS ENSEMBL:ENSG00000133703 KRAS HGNC:6407 KRAS KEGG:hsa:3845 KRAS Monarch:3845 KRAS NCBI Gene:3845 KRAS OMIM:190070 KRAS UCSC:P01116 KRAS Reference Transcript

• RefSeq:NM_001369786.1 KRAS
• RefSeq:NM_033360.4 KRAS
• RefSeq:XM_011520653.2 KRAS
• RefSeq:NM_001369787.1 KRAS
• RefSeq:NM_004985.4 KRAS
• RefSeq:XM_006719069.3 KRAS

Participates as a candidate of

• RAS GEF mutants [plasma membrane] (Homo sapiens)

Other forms of this molecule S-Farn-Me-PalmS KRAS [plasma membrane] p-Y32-S-Farn-Me-PalmS KRAS [plasma membrane] KRAS A146T [plasma membrane] KRAS K147E [plasma membrane] KRAS K147T [plasma membrane] KRAS V14G [plasma membrane] KRAS A146V [plasma membrane] KRAS A146S [plasma membrane] KRAS A146P [plasma membrane] KRAS P34R [plasma membrane] KRAS P34L [plasma membrane] KRAS G12A [plasma membrane] KRAS G12R [plasma membrane] KRAS G13V [plasma membrane] KRAS G13S [plasma membrane] KRAS G13C [plasma membrane] KRAS G13R [plasma membrane] KRAS G13A [plasma membrane] KRAS K5N [plasma membrane] KRAS G12S [plasma membrane] KRAS Q61L [plasma membrane] KRAS Q61K [plasma membrane] KRAS Q61R [plasma membrane] KRAS F156L [plasma membrane] KRAS G12C [plasma membrane] proKRAS [cytosol] S-Farn-proKRAS [endoplasmic reticulum membrane] S-Farn-KRAS [endoplasmic reticulum membrane] S-Farn-Me KRAS [endoplasmic reticulum membrane] KRAS [plasma membrane] KRAS A59T [plasma membrane] KRAS E63K [plasma membrane] KRAS G60D [plasma membrane] KRAS G60V [plasma membrane] KRAS Q22K [plasma membrane] KRAS D33E [plasma membrane] KRAS G60R [plasma membrane] KRAS T58I [plasma membrane] KRAS G13D [plasma membrane] KRAS D153V [plasma membrane] KRAS G12V [plasma membrane] KRAS V14I [plasma membrane] KRAS Q61H [plasma membrane] KRAS Q22R [plasma membrane] KRAS K117N [plasma membrane] KRAS Q22E [plasma membrane] KRAS G12D [plasma membrane] KRAS L19F [plasma membrane] Modified Residues Name L-lysine 147 replaced with L-asparagine Coordinate 147 PsiMod L-asparagine residue [MOD:00012] A protein modification that effectively converts a source amino acid residue to an L-asparagine. L-lysine removal [MOD:01642] A protein modification that effectively removes or replaces an L-lysine. Disease

Name	Identifier	Synonyms
cardiofaciocutaneous syndrome	DOID:0060233	CFC syndrome, cardio-facial-cutaneous syndrome
head and neck squamous cell carcinoma	DOID:5520	carcinoma of the head and neck, squamous cell carcinoma of the head and neck

Cross References RefSeq NP_203524.1, NP_004976.2, XP_011518955.1, NP_001356716.1, NP_001356715.1, XP_006719132.1 Guide to Pharmacology - Targets 2824 ClinGen CA384151058, CA384151056 OpenTargets ENSG00000133703 ENSEMBL ENSP00000509238, ENST00000311936, ENSP00000256078, ENST00000685328, ENST00000688940, ENSG00000133703, ENST00000256078, ENSP00000308495, ENSP00000508921 Mondo 0015280 ZINC - Substances RASK_HUMAN ZINC target P01116 PRO P01116 PDB 6GJ6, 8STM, 6F76, 8R7W, 8T75, 6V6F, 4TQ9, 8EDY, 8B00, 1N4R, 6TAN, 5VBM, 4M21, 6GOG, 6USX, 4PZZ, 8TBK, 4M1T, 6P8Y, 6QUX, 8QUG, 8G9Q, 7EYX, 7T47, 6YR8, 2MSD, 8X6R, 5V71, 6ASE, 7ROV, 9BI1, 5WHE, 6FA1, 7KYZ, 8TXK, 7MDP, 7EWA, 7STF, 8EZG, 6T5B, 8FMI, 7RP3, 8WTE, 6W4F, 8AZV, 8B6I, 4DSN, 6O46, 6OIM, 8AFD, 8STN, 8R7X, 8AQ7, 8PI0, 7RT3, 6GQY, 5VQ8, 8TBH, 1N4Q, 4TQA, 6TAM, 6PTW, 9BG1, 5VP7, 8VR9, 8DVG, 8G4F, 7T1F, 6UT0, 5OCT, 6MBU, 5VQ6, 5O2T, 7OK4, 7RSE, 8DGT, 5KYK, 6XGV, 6B0Y, 6PQ3, 6XHA, 6VJJ, 8K4V, 6WS2, 8TY2, 8AZY, 7LC1, 7EWB, 6EPP, 8FMJ, 5TB5, 7RP4, 7O70, 8EIE, 8BE3, 6O4Z, 6GJ5, 7Q9U, 8UN5, 7KMR, 4OBE, 6OB2, 8ONV, 5VQ1, 7A1X, 6GQX, 7ACH, 8T74, 6GOF, 4LYF, 4LRW, 8TBF, 4M22, 8JGD, 6P8X, 7RSC, 6ARK, 8DGS, 9KPM, 8PIY, 8QU8, 7RT5, 4EPW, 2MSC, 7R0Q, 8EBZ, 6XGU, 8WUL, 6MS9, 9BHQ, 8BE4, 8EPW, 8TXH, 6BOF, 6CCX, 8T73, 8AZZ, 8CX5, 8TXG, 6W4E, 5WPM, 4DSO, 6FA4, 7TLK, 6USZ, 6O36, 5V9L, 4Q03, 6GJ8, 1KZO, 8AQ5, 9E5F, 4LDJ, 7ACA, 6T5V, 7A1W, 5VQ0, 8UN4, 7C40, 4L8G, 4M1Y, 8QVU, 8EER, 8TBL, 6QUU, 7RT4, 5VPZ, 4M1W, 6ASA, 6JTP, 6V65, 8DNJ, 6JTO, 6XHB, 7RPZ, 7VVB, 6P8Z, 9BI2, 8K4T, 8ECR, 6EPL, 8RRO, 8UN3, 1N4P, 8YJ2, 8AZR, 6EPO, 7F0W, 7A47, 6FA3, 6MQG, 5WHD, 6O51, 9BFY, 8AFB, 6PTS, 8JHL, 5V6V, 7OO7, 7KFZ, 7LZ5, 5V9O, 6T5U, 5OCO, 8VGQ, 8TBN, 9BFW, 4LYH, 6E6G, 8QW6, 8TBM, 6QUW, 7A1Y, 5O2S, 5VQ2, 4EPX, 5OCG, 5VPI, 6ZL5, 8VJZ, 4EPR, 6JTN, 7EW9, 9BHO, 4LV6, 8I5C, 6VC8, 6O4Y, 5US4, 4Q01, 8DNK, 8TXE, 6WS4, 8FMK, 8YIV, 9AX6, 4QL3, 6OB3, 7ACQ, 6ZLI, 5UQW, 6V5L, 6GJ7, 7RP2, 6E6F, 5WLB, 4LYJ, 7YV1, 8T71, 8I5E, 8TVK, 6GOE, 8T4V, 8RNI, 8QW7, 5W22, 5VPY, 8G4H, 7RT1, 7C41, 4LPK, 9KPN, 1D8D, 8B69, 4EPY, 6N2K, 8CPR, 6YXW, 6M9W, 5WHA, 8VRA, 6B0V, 5UFE, 8JJS, 7TLE, 8I5D, 6FA2, 7YCE, 7NY8, 8TY9, 9E9I, 8UDR, 8VRB, 8AZX, 8V3A, 1KZP, 6EPN, 5F2E, 7W5R, 6WGN, 4NMM, 8T72, 8AFC, 8F0M, 9E5D, 7ACF, 6H47, 5YY1, 7U8H, 6GQT, 8G9P, 4M1S, 5XCO, 8TBJ, 7SCW, 6MBT, 7R0M, 3GFT, 7LGI, 8S8C, 4EPT, 7TLG, 6PGP, 5TAR, 6CCH, 5MLA, 2MSE, 6MQN, 4Q02, 8TXJ, 6MNX, 8G42, 7LC2, 7YUZ, 8BE5, 5UK9, 4PZY, 7MQU, 9C15, 9BFZ, 1N4S, 5UFQ, 6MTA, 5YXZ, 6BP1, 5V9U, 1D8E, 6H46, 6P0Z, 6P8W, 6QUV, 6GOD, 6CC9, 7SCX, 7RT2, 8B78, 4M1O, 6GQW, 6GOM, 7OK3, 6MBQ, 8K50, 9E9H, 4EPV, 6N2J, 7R0N, 5MLB, 6PGO, 4WA7, 9BHP, 8TY8, 4LUC, 8BLR, 6O53, 5WHB, 6CU6, 8DNI, 5USJ, 8V39, 5V6S, 8G47, 7YCC, 6EPM COSMIC COSV55683801, COSV55683801 GeneCards KRAS HPA ENSG00000133703-KRAS Pharos - Targets P01116 Orphanet KRAS HMDB Protein HMDBP08526 Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04049 RAF1	20	p-S338,Y340,Y341-RAF1 [cytosol] (R-HSA-5624465) p-S338-RAF1 [cytosol] (R-HSA-5624469) p-S621-RAF1 S259F [cytosol] (R-HSA-9656124) p-S621-RAF1 S257L [cytosol] (R-HSA-9656121) p-S621-RAF1 P261L [cytosol] (R-HSA-9656106) p-S621-RAF1 N262K [cytosol] (R-HSA-9656101) p-S621-RAF1 P261A [cytosol] (R-HSA-9656103) p-S621-RAF1 P261S [cytosol] (R-HSA-9656113) p-S621-RAF1 S259T [cytosol] (R-HSA-9656130) p-S621-RAF1 P261T [cytosol] (R-HSA-9656115) p-S621-RAF1 P261R [cytosol] (R-HSA-9656110) p-S621-RAF1 S259P [cytosol] (R-HSA-9656127) p-S621-RAF1 T260I [cytosol] (R-HSA-9656136) p-S621-RAF1 T260R [cytosol] (R-HSA-9656139) p-S621-RAF1 V263A [cytosol] (R-HSA-9656148) p-S621-RAF1 R256S [cytosol] (R-HSA-9656119) p-S621-RAF1 T491I [cytosol] (R-HSA-9656143) p-S621-RAF1 D486N [cytosol] (R-HSA-9656088) p-S621-RAF1 S427G [cytosol] (R-HSA-9656134) p-S621-RAF1 L613V [cytosol] (R-HSA-9656098)	0.695	6
UniProt:P15056 BRAF	20	p-S,T-BRAF [cytosol] (R-HSA-169856) BRAF(1-380)-MACF1(600-7388)fusion [cytosol] (R-HSA-6802402) p-BRAF(1-380)-MACF1(600-7388) fusion [cytosol] (R-HSA-6802536) BRAF E501G [cytosol] (R-HSA-9651132) BRAF D594N [cytosol] (R-HSA-6802299) BRAF D638E [cytosol] (R-HSA-9651125) BRAF G596R [cytosol] (R-HSA-6802385) BRAF D594V [cytosol] (R-HSA-6802305) BRAF G596V [cytosol] (R-HSA-9651138) BRAF G466E [cytosol] (R-HSA-6802374) BRAF D594G [cytosol] (R-HSA-6802295) BRAF L505H [cytosol] (R-HSA-9648845) BRAF F595L [cytosol] (R-HSA-6802316) BRAF L597V [cytosol] (R-HSA-6802397) BRAF G464E [cytosol] (R-HSA-6802369) BRAF N581D [cytosol] (R-HSA-9651152) BRAF E586K [cytosol] (R-HSA-6802308) BRAF V600K [cytosol] (R-HSA-6802502) BRAF A246P [cytosol] (R-HSA-9651123) BRAF G469V [cytosol] (R-HSA-9648620)	0.68	5
UniProt:Q99755 PIP5K1A	1	PIP5K1A [cytosol] (R-HSA-1806260)	0.661	9
UniProt:Q96II5 Q96II5	0.556	3
UniProt:P50749 RASF2	0.544	2
UniProt:O75915 ARL6IP5	1	ARL6IP5 [cytosol] (R-HSA-2980942)	0.519	2
UniProt:P61586 RHOA	6	RHOA [plasma membrane] (R-HSA-194510) RHOA [cell junction] (R-HSA-2134503) RHOA [cytosol] (R-HSA-194866) RHOA [ficolin-1-rich granule membrane] (R-HSA-6804971) RHOA [secretory granule membrane] (R-HSA-6804980) RHOA [endoplasmic reticulum membrane] (R-HSA-5672082)	0.519	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.483	2
UniProt:P28288 ABCD3	2	ABCD3 [cytosol] (R-HSA-1456459) ABCD3 [peroxisomal membrane] (R-HSA-1456468)	0.483	2
UniProt:P01111 NRAS	20	S-Farn-Me PalmS NRAS [plasma membrane] (R-HSA-9647910) proNRAS [cytosol] (R-HSA-9647758) S-Farn-proNRAS [endoplasmic reticulum membrane] (R-HSA-9647928) S-Farn NRAS [endoplasmic reticulum membrane] (R-HSA-9647782) S-Farn-Me NRAS [endoplasmic reticulum membrane] (R-HSA-9647891) S-Farn-Me PalmS NRAS [Golgi membrane] (R-HSA-9647906) NRAS [plasma membrane] (R-HSA-62725) S-Farn-Me NRAS [plasma membrane] (R-HSA-9647893) NRAS Q60E [plasma membrane] (R-HSA-9656589) NRAS G12D [plasma membrane] (R-HSA-6802339) NRAS G12S [plasma membrane] (R-HSA-6802347) NRAS G13D [plasma membrane] (R-HSA-6802363) NRAS Q61K [plasma membrane] (R-HSA-6802446) NRAS Q61L [plasma membrane] (R-HSA-6802455) NRAS Q61R [plasma membrane] (R-HSA-6802461) NRAS Q61P [plasma membrane] (R-HSA-9649680) NRAS G12A [plasma membrane] (R-HSA-9649657) NRAS G12R [plasma membrane] (R-HSA-9649662) NRAS G12C [plasma membrane] (R-HSA-9649660) NRAS G12V [plasma membrane] (R-HSA-9649666)	0.483	2
UniProt:Q7KZI7 MARK2	0.483	2
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.483	2
ChEBI:16618 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,4,5-TRISPHOSPHATE	0.462	2

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