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Lenalidomide (CC-5013)
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Lenalidomide (CC-5013)
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Lenalidomide (CC-5013)
Lenalidomide (CC-5013)Catalog No. A4211 Add to CompareAntineoplastic agent,inhibits angiogenesis Skip to the end of the images gallery Skip to the beginning of the images galleryOrder Through VWR
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Size
Price
Stock
Qty
10mM (in 1mL DMSO)
$61.00
In stock
Evaluation Sample
$30.00
In stock
50mg
$55.00
In stock
100mg
$73.00
In stock
500mg
$131.00
In stock
For scientific research use only and should not be used for diagnostic or medical purposes.
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mRNA synthesis
In vitro transcription of capped mRNA with modified nucleotides and Poly(A) tail
Tyramide Signal Amplification (TSA)
TSA (Tyramide Signal Amplification), used for signal amplification of ISH, IHC and IC etc.
Phos Binding Reagent Acrylamide
Separation of phosphorylated and non-phosphorylated proteins without phospho-specific antibody
Cell Counting Kit-8 (CCK-8)
A convenient and sensitive way for cell proliferation assay and cytotoxicity assay
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Protect the integrity of proteins from multiple proteases and phosphatases for different applications.
Background
Product Citation
Chemical Properties
Protocol
Biological Activity
Quality Control
Background
Lenalidomide (also known as CC-5013), an oral derivative of thalidomide, is an antineoplastic agent exhibiting antitumor activity through a variety of mechanisms, including immune system activation, angiogenesis inhibition, and direct antineoplastic effects. It has been extensively studied for the treatment of multiple myeloma and myelodysplastic syndrome as well as lymphoproliferative disorders including chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma. According to recent studies, Lnalidomide promotes and restores immune system function in CLL patients by inducing an overexpression of costimulatory molecules in leukemic lymphocytes to restore the humoral immunity and immunoglobulins production as well as improving the ability of T cells and leukemic cells to form synapses with T lymphocytes.
Reference
Ana Pilar Gonzalez-Rodriguez, Angel R. Payer, Andrea Acebes-Huerta, Leticia Hergo-Zapico, Monica Villa-Alvarez, Esther Gonzalez-Garcia, and Segundo Gonzalez. Lenalidomide and chronic lymphocytic leukemia. BioMed Research International 2013.
Product Citation
1. Girish Nallur. "The BET inhibitors JQ1, AZD5153, and I-BET151 co-opt ubiquitin proteasome system components for altering expression of the BRD4 interactome in a human B cell line." bioRvix. November 10, 2023.
2. Ying Jin, Jie Zhou, et al. "Electroacupuncture alleviates the transition from acute to chronic pain through the p38 MAPK/TNF-α signalling pathway in the spinal dorsal horn." Acupunct Med. 2021 Dec;39(6):708-715. PMID:34308662
Chemical Properties
Physical Appearance
A solid
Storage
Store at -20°C
M.Wt
259.3
Cas No.
191732-72-6
Formula
C13H13N3O3
Synonyms
Revlimid,IMiD3,CC 5013,CDC-501,CDC 501
Solubility
insoluble in EtOH; insoluble in H2O; ≥100.8 mg/mL in DMSO
Small Molecules with Blue Ice, Modified Nucleotides with Dry Ice.
General tips
We do not recommend long-term storage for the solution, please use it up soon.
Protocol
Cell experiment: [1]
Cell lines
Peripheral blood mononuclear cells (PBMCs)
Preparation method
The solubility of this compound in DMSO is >10 mM. General tips for obtaining a higher concentration: Please warm the tube at 37 °C for 10 minutes and/or shake it in the ultrasonic bath for a while.Stock solution can be stored below -20°C for several months.
Reaction Conditions
10 μM, 7 days
Applications
The cells were incubated with the dye at 37°C for 10 min and treated for 7 days in RPMI culture medium with lenalidomide. Cells were surface stained with anti-CD4-PerCP and anti-CD25-APC, followed by intracellular staining with anti-FOXP3-PE. Lenalidomide inhibited the expression of CD4+CD25high CTLA-4+FOXP3+ cells. Incubation with lenalidomide significantly decreases expression of the T regulatory cell population after 7 days of culture. The drug decreased the percentage of CD4+CD25high cells expressing both CTLA-4 and FOXP3 from 25 to 12%.
Animal experiment: [2]
Animal models
Male Sprague–Dawley rats
Dosage form
Oral administration, 50 mg/kg or 250 mg/kg
Applications
In the rat mesenteric window assay (RMWA), representative differences between vehicle and 50 or 250 mg/kg lenalidomide-treated rats were visualized by staining with an antibody against rat endothelium in bFGF-induced angiogenic windows. The induction of angiogenesis by bFGF was significantly inhibited by oral treatment of lenalidomide in a dose-dependent manner. Lenalidomide significantly decreased the percentage of vascularized area from 5.16% in the control group to 2.58 and 1.69 in the 50 and 250 mg/kg group, respectively.
Other notes
Please test the solubility of all compounds indoor, and the actual solubility may slightly differ with the theoretical value. This is caused by an experimental system error and it is normal.
References:
[1] Galustian C, Meyer B, Labarthe M C, et al. The anti-cancer agents lenalidomide and pomalidomide inhibit the proliferation and function of T regulatory cells. Cancer Immunology, Immunotherapy, 2009, 58(7): 1033-1045.
[2] Dredge K, Horsfall R, Robinson S P, et al. Orally administered lenalidomide (CC-5013) is anti-angiogenic in vivo and inhibits endothelial cell migration and Akt phosphorylation in vitro. Microvascular research, 2005, 69(1): 56-63.
Biological Activity
Description
Lenalidomide (CC-5013) is an inhibitor of TNF-α secretion with IC50 of 13 nM.
Targets
TNF-α
IC50
13 nM
Quality Control
Quality Control & MSDS
View current batch: 4 3 2 1
Purity = 96.25%
COA (Certificate Of Analysis)
HPLC
NMR (Nuclear Magnetic Resonance)
MSDS (Material Safety Data Sheet)
Datasheet
Purity = 99.83%
COA (Certificate Of Analysis)
HPLC
NMR (Nuclear Magnetic Resonance)
MSDS (Material Safety Data Sheet)
Datasheet
Purity = 98.88%
COA (Certificate Of Analysis)
HPLC
NMR (Nuclear Magnetic Resonance)
MSDS (Material Safety Data Sheet)
Datasheet
Purity = 98.66%
COA (Certificate Of Analysis)
HPLC (Retest)
NMR (Nuclear Magnetic Resonance)
MSDS (Material Safety Data Sheet)
Datasheet
Chemical structure
Related Biological Data
Related Biological Data
Related Biological Data
Related Products
A4213 Necrostatin-1
A3547 Lenalidomide hydrochloride
B1188 Lenalidomide hemihydrate
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