Lenalidomide (CC-5013) | Immunomodulator - MedChemExpress

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1. PROTAC Apoptosis
2. Ligands for E3 Ligase Molecular Glues Apoptosis
3. Lenalidomide

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Lenalidomide (CC-5013), a derivative of Thalidomide, acts as molecular glue. Lenalidomide is an orally active immunomodulator. Lenalidomide (CC-5013) is a ligand of ubiquitin E3 ligase cereblon (CRBN), and it causes selective ubiquitination and degradation of two lymphoid transcription factors, IKZF1 and IKZF3, by the CRBN-CRL4 ubiquitin ligase. Lenalidomide (CC-5013) specifically inhibits growth of mature B-cell lymphomas, including multiple myeloma, and induces IL-2 release from T cells.

For research use only. We do not sell to patients.

Lenalidomide Chemical Structure

CAS No. : 191732-72-6

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Based on 43 publication(s) in Google Scholar

Other Forms of Lenalidomide:

• Lenalidomide hemihydrate In-stock
• Lenalidomide-d5 Get quote
• Lenalidomide-13C5,15N Get quote
• rac-Lenalidomide-13C5 Get quote
• Lenalidomide hydrochloride Get quote
• Lenalidomide sodium Get quote
• Lenalidomide (Standard) Get quote

Lenalidomide Related Antibodies

39 Publications Citing Use of MCE Lenalidomide

• •Nature. 2024 Sep;633(8030):670-677. [Abstract]
• •Cancer Cell. 2022 Aug 26;S1535-6108(22)00372-5. [Abstract]
• •Cell. 2018 Sep 20;175(1):171-185.e25. [Abstract]
• •Nat Cancer. 2022 May;3(5):595-613. [Abstract]
• •Nat Commun. 2017 May 22;8:15398. [Abstract]
• •Cancer Res. 2024 Oct 22. [Abstract]

• •Cell Rep Med. 2024 Mar 19;5(3):101472. [Abstract]
• •Nat Chem Biol. 2021 Jun;17(6):711-717. [Abstract]
• •Cell Rep. 2024 May 8;43(5):114211. [Abstract]
• •Acta Pharmacol Sin. 2020 Sep;41(9):1246-1254. [Abstract]
• •Cell Syst. 2018 Apr 25;6(4):424-443.e7. [Abstract]
• •Free Radic Biol Med. 2023 Apr 10;S0891-5849(23)00373-8. [Abstract]
• •Biochim Biophys Acta Mol Basis Dis. 2022 Jun 22;166472. [Abstract]
• •Elife. 2018 Aug 1;7:e38430. [Abstract]
• •Cancers (Basel). 2024 Mar 28, 16(7), 1319.
• •Clin Chim Acta. 2023 Dec 14:117707. [Abstract]
• •Cancer Sci. 2019 Dec;110(12):3802-3810. [Abstract]
• •Int J Mol Sci. 2023 Sep 14, 24(18), 14097.
• •Front Cell Infect Microbiol. 2022 Jul 28;12:954814. [Abstract]
• •iScience. 19 July 2022, 104781.
• •ACS Pharmacol Transl Sci. 2021 Feb 26.
• •Food Chem Toxicol. 2019 Mar;125:392-402. [Abstract]
• •Inflammation. 2019 Feb;42(1):221-234. [Abstract]
• •Oncol Rep. 2018 Jun;39(6):2873-2880. [Abstract]
• •Am J Pathol. 2015 Jun;185(6):1783-94. [Abstract]
• •Cell Rep Methods. 2023 Oct 23;3(10):100599. [Abstract]
• •Exp Cell Res. 2020 Aug 1;393(1):112054. [Abstract]
• •Patent. US20240261246A1.
• •bioRxiv. 2024 June 12.
• •Universidad de Navarra. 2024 Feb 28.
• •Patent. US20220332776A1.
• •Oxid Med Cell Longev. 29 Dec 2021.
• •Patent. US20210379039A1.
• •University of Washington. The Columbian College of Arts and Sciences. August 31, 2021.
• •bioRxiv. April.
• •Patent. US20180263995A1.
• •Patent. US20170360780A1.
• •Faculty of Science, Masaryk University. Department of Experimental Biology.2014.
• •Harvard Medical School LINCS LIBRARY

Lenalidomide purchased from MedChemExpress. Usage Cited in: Cell. 2018 Sep 20;175(1):171-185.e25. [Abstract]

Lenalidomide purchased from MedChemExpress. Usage Cited in: Elife. 2018 Aug 1;7:e38430. [Abstract]

Lenalidomide purchased from MedChemExpress. Usage Cited in: Oncol Rep. 2018 Jun;39(6):2873-2880. [Abstract]

Lenalidomide purchased from MedChemExpress. Usage Cited in: Nat Commun. 2017 May 22;8:15398. [Abstract]

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• Customer Review

• [1]. Krönke J, et al. Lenalidomide induces degradation of IKZF1 and IKZF3. Oncoimmunology. 2014 Jul 3;3(7):e941742.

  [2]. Kotla V, et al. Mechanism of action of lenalidomide in hematological malignancies. J Hematol Oncol. 2009 Aug 12;2:36.

  [3]. Lopez-Girona A, et al. Cereblon is a direct protein target for immunomodulatory and antiproliferative activities of lenalidomide and pomalidomide. Leukemia. 2012 Nov;26(11):2326-35.

  [4]. Rozewski DM, et al. Pharmacokinetics and tissue disposition of lenalidomide in mice. AAPS J. 2012 Dec;14(4):872-82.

  [5]. Minzel W, et al. Small Molecules Co-targeting CKIα and the Transcriptional Kinases CDK7/9 Control AML in Preclinical Models. Cell. 2018 Sep 20;175(1):171-185.e25.

  [6]. Nagashima, Takeyuki, et al. PHARMACEUTICAL COMPOSITION COMPRISING BICYCLIC NITROGEN-CONTAINING AROMATIC HETEROCYCLIC AMIDE COMPOUND AS ACTIVE INGREDIENT. Patent. 20170360780A1.

  [7]. Omran A, et al. Effects of MRP8, LPS, and lenalidomide on the expressions of TNF-α , brain-enriched, and inflammation-related microRNAs in the primary astrocyte culture. ScientificWorldJournal. 2013 Sep 21;2013:208309.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.Storage method and period of stock solution: -80°C, 1 year; -20°C, 6 months. When stored at -80°C, please use it within 1 year. When stored at -20°C, please use it within 6 months.

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Lenalidomide Related Classifications

• Inflammation/Immunology Cancer
• Cancer Targeted Therapy Cancer Immunotherapy Cancer Metabolism and Metastasis

• PROTAC Apoptosis
• Ligands for E3 Ligase Molecular Glues Apoptosis

• Do most proteins show cross-species activity?

  Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lenalidomide191732-72-6CC-5013CC5013CC 5013Ligands for E3 LigaseMolecular GluesApoptosisE3 ligase-recruiting MoietydegradationIKZF1IKZF3multiplemyelomaanalogimmunomodulatoryE3ligasecereblonCRL4ligandInhibitorinhibitorinhibit

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