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Immunogenicity 3736

summary

Sample ID 3942Response NegativeTumor Type Rectal cancerGene Symbol SORBS2Transcript ID uc003iyn.1 HLA INFO DQA*02:01 / DQB*02:02 TCR INFO

No TCR info found!

T cell Tumor cell { DQA*02:01 DQB*02:02

sequence

Full length protein sequence (671 aa)

MNTGR1 DSQSP6 DSAKG11 FRSVR16 PNLQD21 KRSPT26 QSQIT31 VNGNS36 GGAVS41 PMSYY46 QRPFS51 PSAYS56 LPASL61 NSSIV66 MQHGT71 SLDST76 DTYPQ81 HAQSL86 DGTTS91 SSIPL96 YRSSE101 EEKRV106 TVIKA111 PHYPG116 IGPVD121 ESGIP126 TAIRT131 TVDRP136 KDWYK141 TMFKQ146 IHMVH151 KPDDD156 TDMYN161 TPYTY166 NAGLY171 NPPYS176 AQSHP181 AAKTQ186 TYRPL191 SKSHS196 DNSPN201 AFKDA206 SSPVP211 PPHVP216 PPVPP221 LRPRD226 RSSTE231 KHDWD236 PPDRK241 VDTRK246 FRSEP251 RSIFE256 YEPGK261 SSILQ266 HERPP271 PLPTT276 PTPVP281 REPGR286 KPLSS291 SRLGE296 VTGSP301 SPPPR306 SGAPT311 PSSRA316 PALSP321 TRPPK326 KPLDY331 VQDHS336 SGVFN341 EASLY346 QSSID351 RSLER356 PMSSA361 SMASD366 FRKRR371 KSEPA376 VGPPR381 GLGDQ386 SASRT391 SPGRV396 DLPGS401 STTLT406 KSFTS411 SSPSS416 PSRAK421 DRESP426 RSYSS431 TLTDM436 GRSAP441 RERRG446 TPEKE451 KLPAK456 AVYDF461 KAQTS466 KELSF471 KKGDT476 VYILR481 KIDQN486 WYEGE491 HHGRV496 GIFPI501 SYVEK506 LTPPE511 KAQPA516 RPPPP521 AQPGE526 IGEAI531 AKYNF536 NADTN541 VELSL546 RKGDR551 VILLK556 RVDQN561 WYEGK566 IPGTN571 RQGIF576 PVSYV581 EVVKK586 NTKGA591 EDYPD596 PPIPH601 SYSSD606 RIHSL611 SSNKP616 QRPVF621 THENI626 QGGGE631 PFQAL636 YNYTP641 RNEDE646 LELRE651 SDVID656 VMEKC661 DDGWF666 V671

Mutation Information

DNA mutation: None Peptide Range: 623 ~ 647 Mut AA position: 635 (13 in Wild Type peptide)

Alignment

Wild Type: "PVFTHENIQGGGEPFQALYNYTPRN ||||||||||||.|||||||||||| Mutant: PVFTHENIQGGGVPFQALYNYTPRN"

reference

Science, 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers

Gene Name (from Reference) SORBS2

clinic trial

Checkpoint Blockade

None

ACT

None

Vaccination

None

Curative Effect

None

experiment

minimal_peptide

None

Antigen Type

TMG RNA

T-cell Source

TILs

APC Type

autologous DCs

Assay

IFNg ELISPOT assay