16 thg 10, 2020 · The alternative non-homologous end-joining (NHEJ) pathway promotes DNA double-strand break (DSB) repair in cells deficient for NHEJ or ...
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Most of the NHEJ-deficient cell lines are hypersensitive in G1 phase, leading to conclusion that NHEJ acts primarily in G1. NHEJ has been proposed to act also ... INTRODUCTION · RESULTS · DISCUSSION · MATERIALS AND METHODS
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16 thg 10, 2020 · Given that most mammalian somatic cells reside in G0/G1, NHEJ represents the major pathway for DSB repair and genome maintenance.
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Download scientific diagram | Non-homologous end joining (NHEJ). (A) During the G1 phase, CtIP is ubiquitylated by CRL3 KLHL15 and APC/C, resulting in its ...
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Download scientific diagram | NHEJ of etoposide-induced DSBs in G1/G0 involves CtIP. (A) Identification of cell cycle phases in HeLa cells (see text for ...
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Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. ... NHEJ is active throughout the cell cycle, but is most important during G1 ...
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26 thg 1, 2021 · ASF1A phosphorylation at S166 promotes its interaction with MDC1 and NHEJ repair at DSBs. •. The phosphorylation helps localize 53BP1 at ...
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We show that in G1 yeast cells, NHEJ is a highly effective repair pathway for gamma-ray induced breaks, even when many breaks are present. Pulsed-field gel ...
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Non-homologous end joining (NHEJ) is the major DSB-repair pathway available ... has been hypothesised to consist of a fast and slow component in G0/G1.
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The two main DNA double-strand break (DSB) repair pathways are non-homologous end joining (NHEJ) and homologous recombination (HR). DNA ends are normally ...
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This aspect of telomere NHEJ is mediated through the ATM kinase target ... DNA Ligase IV-dependent NHEJ of deprotected mammalian telomeres in G1 and G2.
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NHEJ is the major repair pathway in mammalian somatic cells, operating in G0/G1 phases of the cell cycle and competing with HR in the late S and G2 phases ...
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In contrast, the processing of dysfunctional telomeres by NHEJ occurred primarily in G1, being repressed in S/G2 in a cyclin-dependent kinase ...
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17 thg 6, 2021 · Although NHEJ is active in all phases of the cell cycle, it occurs most frequently in G1 phase and repairs about 80% of IR-induced DSBs, ...
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