NR3C1 Nuclear Receptor Subfamily 3 Group C Member 1 [ (human)]

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Create FileAdd to ClipboardAdd to Collections NR3C1 nuclear receptor subfamily 3 group C member 1 [ Homo sapiens (human) ] Gene ID: 2908, updated on 25-Nov-2025

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Gene Sequences (FASTA) Transcript sequences (FASTA) Protein sequences(FASTA)

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Summary

Go to the top of the page Help Official Symbol NR3C1provided by HGNC Official Full Name nuclear receptor subfamily 3 group C member 1provided by HGNC Primary source HGNC:HGNC:7978 See related Ensembl:ENSG00000113580 MIM:138040; AllianceGenome:HGNC:7978 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as GR; GCR; GRL; GCCR; GCRST Summary This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] Expression Ubiquitous expression in fat (RPKM 11.8), lung (RPKM 9.9) and 25 other tissues See more Orthologs mouse all NEW Try the new Gene table Try the new Transcript table

Genomic context

Go to the top of the page Help See NR3C1 in Genome Data Viewer Location: 5q31.3 Exon count: 15

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	5	NC_000005.10 (143277931..143435512, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	5	NC_060929.1 (143809293..143966896, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	5	NC_000005.9 (142657496..142815077, complement)

Chromosome 5 - NC_000005.10

Genomic regions, transcripts, and products

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Genomic Sequence: NC_000005.10 Chromosome 5 Reference GRCh38.p14 Primary Assembly NG_009062.1 RefSeqGene NC_060929.1 Chromosome 5 Alternate T2T-CHM13v2.0 NC_000005.9 Chromosome 5 Reference GRCh37.p13 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help See details Tissue-specific circular RNA induction during human fetal development RNA sequencing of total RNA from 20 human tissues HPA RNA-seq normal tissues

• Project title: Tissue-specific circular RNA induction during human fetal development
• Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
• BioProject: PRJNA270632
• Publication: PMID 26076956
• Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

1. Frequencies of Bcl I, E22E, and N363S of h-GR/NR3C1 restriction fragment length polymorphisms of glucocorticoid receptor gene in Polish adult population. Pietras T, et al. Med Sci Monit, 2010 Oct. PMID 20885351
2. [The analysis of the factors influencing the development of glucocorticoid resistance in the etiopathogenesis of severe bronchial asthma]. Panek M, et al. Postepy Biochem, 2010. PMID 21473041
3. Effects of chronic academic stress on mental state and expression of glucocorticoid receptor α and β isoforms in healthy Japanese medical students. Kurokawa K, et al. Stress, 2011 Jul. PMID 21438768
4. Glucocorticoid receptor haplotype is associated with a decreased risk of delirium in the elderly. Manenschijn L, et al. Am J Med Genet B Neuropsychiatr Genet, 2011 Apr. PMID 21438141
5. The dominant negative β isoform of the glucocorticoid receptor is uniquely expressed in erythroid cells expanded from polycythemia vera patients. Varricchio L, et al. Blood, 2011 Jul 14. PMID 21355091, Free PMC Article

See all (1287) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity. Title: The Glucocorticoid Receptor: Isoforms, Functions, and Contribution to Glucocorticoid Sensitivity.
2. The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia. Title: The relationship of the methylation status and polymorphism of glucocorticoid receptor gene (NR3C1) with attempted suicide or non-suicidal self-injury patients in schizophrenia.
3. Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study. Title: Maternal perceived stress and green spaces during pregnancy are associated with adult offspring gene (NR3C1 and IGF2/H19) methylation patterns in adulthood: A pilot study.
4. Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly. Title: Association between NR3C1 gene polymorphisms and age-related hearing impairment in Qingdao Chinese elderly.
5. Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation? Title: Maternal sensitivity and child internalizing and externalizing behavior: a mediating role for glucocorticoid receptor gene (NR3C1) methylation?
6. Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental NR3C1 and FKBP5 methylation. Title: Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental NR3C1 and FKBP5 methylation.
7. Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury. Title: Methylation of the Glucocorticoid Receptor Gene (NR3C1) in Adolescents with a History of Childhood Adversity Engaging in Non-Suicidal Self-Injury.
8. Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer. Title: Glucocorticoid Receptor (GR) Activation Is Associated with Increased cAMP/PKA Signaling in Castration-Resistant Prostate Cancer.
9. Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer. Title: Chromatin accessibility and pioneer factor FOXA1 restrict glucocorticoid receptor action in prostate cancer.
10. The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families. Title: The glucocorticoid receptor gene (NR3C1) is linked to and associated with polycystic ovarian syndrome in Italian families.

Submit: New GeneRIF Correction See all GeneRIFs (857)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Glucocorticoid resistance MedGen: C1841972 OMIM: 615962 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies new susceptibility loci for migraine.EBI GWAS CatalogEBI GWAS CatalogPubMed
Genomewide pharmacogenomic study of metabolic side effects to antipsychotic drugs.EBI GWAS CatalogEBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Vpr	vpr	Glucocorticoid receptor (GR) agonists, dexamethasone (Dex) and medroxyprogesterone acetate (MPA), enhance HIV-1 Vpr peptide (amino acids 52-96)-mediated apoptosis of CD4+ T-cells in a GR-dependent manner	PubMed
vpr	HIV-1 Vpr leucine residues mediate Vpr-Glucocorticoid Receptor (GR) interaction and promoter transactivation; mutation at residue L22 results in 8- to 11-fold higher GRE and HIV-1 LTR transactivation, while L42 and L67 mutants showed reduced activation	PubMed
vpr	HIV-1 Vpr activates transcription of glucocorticoid-responsive promoters by binding directly to p300/CBP co-activators, forming a stable complex with p300 and interacting with ligand-bound glucocorticoid receptor	PubMed
vpr	HIV-1 Vpr potentiates the trans-activation, but not the trans-repression, properties of the glucocorticoid receptor on NF-kappa B and activating protein 1-regulated simple promoters	PubMed
vpr	HIV-1 Vpr (amino acids 22-26 and 64-68) binds to and activates glucocorticoid receptor (GR) and transactivates the HIV-1 LTR promoter through the host GR pathway	PubMed
vpr	HIV-1 Vpr targets the glucocorticoid receptor type II complex through an interaction with Vpr interacting protein 1 (Rip-1), a 41 kDa cytosolic protein that binds to Vpr and in a complex with the human glucocorticoid receptor	PubMed
vpr	HIV-1 Vpr affects the gene expression of glucocorticoid-regulated genes (IL-12, CD44, Toll-like receptor 4 and indolamine 2,3-dioxygenase, macrophage receptor with collagenous structure, and thrombospondin 1) through activation of the GR pathway	PubMed
vpr	Studies suggest effects of HIV-1 Vpr on cytokine expression (IL-2, IL-10, IL-12, TNFalpha and IL-4) and T-cell proliferation may be mediated through activation of the glucocorticoid receptor pathway	PubMed
vpr	Interaction of HIV-1 Vpr and hVIP/mov34 may be involved in the activation of glucocorticoid receptor by Vpr	PubMed
vpr	Transcription factors TFIIH, CDK7, Cyclin H, and MAT1 enhance HIV-1 Vpr activation of glucocorticoid receptor	PubMed
vpr	HIV-1 Vpr synergistically enhances SRC-1 ligand-activated glucocorticoid receptor activity	PubMed
vpr	HIV-1 Vpr (amino acids 1-35) binds to TFIID, an interaction that is associated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed
vpr	Specific binding of HIV-1 Vpr (amino acids 15-35) to TFIIB (amino acids 52-55) causes a conformational change in TFIIB and is correlated with the ability of Vpr to stimulate transcription through the glucocorticoid receptor pathway	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

• G42349 (e-PCR)
  • UniSTS:94208

• RH104235 (e-PCR)
  • UniSTS:98560

• PMC64995P2 (e-PCR)
  • UniSTS:273428

• NR3C1_1004 (e-PCR)
  • UniSTS:277539

• NR3C1_V270 (e-PCR)
  • UniSTS:277539

• NR3C1 (e-PCR)
  • UniSTS:504891

• STS-U25029 (e-PCR)
  • UniSTS:57947

• D5S2378 (e-PCR)
  • UniSTS:3680

• SHGC-58162 (e-PCR)
  • UniSTS:33390

• L31444 (e-PCR)
  • UniSTS:10390

• RH68907 (e-PCR)
  • UniSTS:74908

• Nr3c1 (e-PCR), detects polymorphism
  • UniSTS:143264

• D5S2472 (e-PCR)
  • UniSTS:9903

• bac51148T (e-PCR)
  • UniSTS:181430

• SHGC-110504 (e-PCR)
  • UniSTS:167866

• SHGC-111096 (e-PCR)
  • UniSTS:168137

• G65702 (e-PCR)
  • UniSTS:225496

• RH16558 (e-PCR)
  • UniSTS:26336

• D5S1871 (e-PCR)
  • UniSTS:35571

• bac51616T (e-PCR)
  • UniSTS:181493

Related pseudogene(s)

1 found   Review record(s) in Gene

Homology

• NCBI Orthologs
Orthologs from OrthoDB

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotationmore info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assaymore info	PubMed
enables DNA-binding transcription factor activity	IDA Inferred from Direct Assaymore info	PubMed
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotationmore info
enables DNA-binding transcription factor activity	TAS Traceable Author Statementmore info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISA Inferred from Sequence Alignmentmore info
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA Inferred from Direct Assaymore info	PubMed
enables Hsp90 protein binding	IPI Inferred from Physical Interactionmore info	PubMed
enables RNA binding	IEA Inferred from Electronic Annotationmore info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assaymore info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assaymore info	PubMed
enables TBP-class protein binding	IPI Inferred from Physical Interactionmore info	PubMed
enables core promoter sequence-specific DNA binding	IDA Inferred from Direct Assaymore info	PubMed
enables estrogen response element binding	IBA Inferred from Biological aspect of Ancestormore info
enables identical protein binding	IEA Inferred from Electronic Annotationmore info
enables lipid binding	IEA Inferred from Electronic Annotationmore info
enables metal ion binding	IEA Inferred from Electronic Annotationmore info
enables nuclear glucocorticoid receptor activity	IEA Inferred from Electronic Annotationmore info
enables nuclear glucocorticoid receptor activity	TAS Traceable Author Statementmore info	PubMed
enables nuclear receptor activity	IBA Inferred from Biological aspect of Ancestormore info
enables nuclear receptor activity	IDA Inferred from Direct Assaymore info	PubMed
enables nuclear steroid receptor activity	IEA Inferred from Electronic Annotationmore info
enables promoter-specific chromatin binding	IEA Inferred from Electronic Annotationmore info
enables protein binding	IPI Inferred from Physical Interactionmore info	PubMed
enables protein kinase binding	IEA Inferred from Electronic Annotationmore info
enables protein kinase binding	IPI Inferred from Physical Interactionmore info	PubMed
enables sequence-specific DNA binding	IEA Inferred from Electronic Annotationmore info
enables sequence-specific double-stranded DNA binding	IDA Inferred from Direct Assaymore info	PubMed
enables sequence-specific double-stranded DNA binding	IEA Inferred from Electronic Annotationmore info
enables steroid binding	IDA Inferred from Direct Assaymore info	PubMed
enables steroid binding	IEA Inferred from Electronic Annotationmore info
enables steroid hormone binding	IDA Inferred from Direct Assaymore info	PubMed
enables zinc ion binding	IEA Inferred from Electronic Annotationmore info

Process	Evidence Code	Pubs
acts_upstream_of_or_within adrenal gland development	IEA Inferred from Electronic Annotationmore info
involved_in apoptotic process	IEA Inferred from Electronic Annotationmore info
involved_in astrocyte differentiation	IEA Inferred from Electronic Annotationmore info
involved_in cell division	IEA Inferred from Electronic Annotationmore info
involved_in cellular response to dexamethasone stimulus	IMP Inferred from Mutant Phenotypemore info	PubMed
involved_in cellular response to glucocorticoid stimulus	IDA Inferred from Direct Assaymore info	PubMed
involved_in cellular response to steroid hormone stimulus	IDA Inferred from Direct Assaymore info	PubMed
involved_in cellular response to transforming growth factor beta stimulus	IDA Inferred from Direct Assaymore info	PubMed
involved_in chromatin organization	IEA Inferred from Electronic Annotationmore info
involved_in chromosome segregation	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within gene expression	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within glucocorticoid metabolic process	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within mammary gland duct morphogenesis	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within maternal behavior	IEA Inferred from Electronic Annotationmore info
involved_in microglia differentiation	IEA Inferred from Electronic Annotationmore info
involved_in motor behavior	IEA Inferred from Electronic Annotationmore info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assaymore info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assaymore info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotypemore info	PubMed
involved_in neuroinflammatory response	IEA Inferred from Electronic Annotationmore info
involved_in nuclear receptor-mediated corticosteroid signaling pathway	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within nuclear receptor-mediated glucocorticoid signaling pathway	IEA Inferred from Electronic Annotationmore info
involved_in nuclear receptor-mediated glucocorticoid signaling pathway	IEA Inferred from Electronic Annotationmore info
involved_in nuclear receptor-mediated steroid hormone signaling pathway	IBA Inferred from Biological aspect of Ancestormore info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotationmore info
involved_in positive regulation of miRNA transcription	IDA Inferred from Direct Assaymore info	PubMed
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within positive regulation of neuron apoptotic process	IEA Inferred from Electronic Annotationmore info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assaymore info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotypemore info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assaymore info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotationmore info
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within regulation of glucocorticoid biosynthetic process	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within regulation of gluconeogenesis	IEA Inferred from Electronic Annotationmore info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestormore info
acts_upstream_of_or_within response to cortisol	IEA Inferred from Electronic Annotationmore info
involved_in response to glucocorticoid	IEA Inferred from Electronic Annotationmore info
involved_in response to ketone	IEA Inferred from Electronic Annotationmore info
acts_upstream_of_or_within response to wounding	IEA Inferred from Electronic Annotationmore info
involved_in signal transduction	TAS Traceable Author Statementmore info	PubMed
involved_in synaptic transmission, glutamatergic	IEA Inferred from Electronic Annotationmore info

Component	Evidence Code	Pubs
located_in centrosome	IEA Inferred from Electronic Annotationmore info
is_active_in chromatin	IBA Inferred from Biological aspect of Ancestormore info
located_in chromatin	ISA Inferred from Sequence Alignmentmore info
located_in chromosome	IEA Inferred from Electronic Annotationmore info
located_in cytoplasm	IDA Inferred from Direct Assaymore info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotationmore info
located_in cytoplasm	TAS Traceable Author Statementmore info	PubMed
located_in cytosol	IDA Inferred from Direct Assaymore info
located_in cytosol	IEA Inferred from Electronic Annotationmore info
located_in cytosol	TAS Traceable Author Statementmore info
located_in membrane	IEA Inferred from Electronic Annotationmore info
located_in mitochondrial matrix	TAS Traceable Author Statementmore info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assaymore info
located_in mitochondrion	IEA Inferred from Electronic Annotationmore info
located_in nuclear speck	IDA Inferred from Direct Assaymore info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assaymore info
located_in nucleoplasm	IEA Inferred from Electronic Annotationmore info
located_in nucleoplasm	TAS Traceable Author Statementmore info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestormore info
located_in nucleus	IC Inferred by Curatormore info	PubMed
is_active_in nucleus	IDA Inferred from Direct Assaymore info	PubMed
located_in nucleus	IDA Inferred from Direct Assaymore info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotationmore info
located_in nucleus	TAS Traceable Author Statementmore info	PubMed
part_of protein-containing complex	IDA Inferred from Direct Assaymore info	PubMed
located_in spindle	IEA Inferred from Electronic Annotationmore info
located_in synapse	IEA Inferred from Electronic Annotationmore info

General protein information

Go to the top of the page Help Preferred Names glucocorticoid receptor Names nuclear receptor subfamily 3 group C member 1 variant hGR-B(54) nuclear receptor subfamily 3 group C member 1 variant hGR-B(77) nuclear receptor subfamily 3 group C member 1 variant hGR-B(93) nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

1. NG_009062.1 RefSeqGene

   Range 36827..162579 Download GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

1. NM_000176.3 → NP_000167.1  glucocorticoid receptor isoform alpha

   See identical proteins and their annotated locations for NP_000167.1

   Status: REVIEWED

   Description Transcript Variant: This variant (1) represents the predominant transcript, and encodes the predominant physiological isoform (alpha, also known as GRalpha or GR-A). Variants 1-5 encode the same isoform. Source sequence(s) AC004782, AC091925, X03225 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Related ENSP00000377977.2, ENST00000394464.7 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

2. NM_001018074.1 → NP_001018084.1  glucocorticoid receptor isoform alpha

   See identical proteins and their annotated locations for NP_001018084.1

   Status: REVIEWED

   Description Transcript Variant: This variant (2) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha). Source sequence(s) AC004782, AC091925, X03225 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

3. NM_001018075.1 → NP_001018085.1  glucocorticoid receptor isoform alpha

   See identical proteins and their annotated locations for NP_001018085.1

   Status: REVIEWED

   Description Transcript Variant: This variant (3) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha) Source sequence(s) AC004782, AC091925, X03225 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

4. NM_001018076.2 → NP_001018086.1  glucocorticoid receptor isoform alpha

   See identical proteins and their annotated locations for NP_001018086.1

   Status: REVIEWED

   Description Transcript Variant: This variant (4) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha). Source sequence(s) AC004782, AC091925, BF966114, X03225 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Related ENSP00000427672.1, ENST00000503201.1 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

5. NM_001018077.1 → NP_001018087.1  glucocorticoid receptor isoform alpha

   See identical proteins and their annotated locations for NP_001018087.1

   Status: REVIEWED

   Description Transcript Variant: This variant (5) contains an alternative 5' terminal non-coding exon, thus has a different 5' UTR compared to variant 1. Variants 1-5 encode the same isoform (alpha). Source sequence(s) AC004782, AC091925, X03225 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Related ENSP00000343205.2, ENST00000343796.6 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

6. NM_001020825.2 → NP_001018661.1  glucocorticoid receptor isoform beta

   See identical proteins and their annotated locations for NP_001018661.1

   Status: REVIEWED

   Description Transcript Variant: This variant (6) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift and a shorter isoform (beta, also known as GRbeta) with a distinct C-terminus compared to isoform alpha. This isoform resides primarily in the nucleus, lacks hormone-binding activity, and has a dominant negative effect on the action of isoform alpha (PMID:8621628). Source sequence(s) AC004782, AC091925, X03348 Consensus CDS CCDS47298.1 UniProtKB/TrEMBL E5KQF5, H6V745 Related ENSP00000387672.2, ENST00000415690.6 Conserved Domains (3) summary cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor cl11397Location:531 → 729 NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

7. NM_001024094.2 → NP_001019265.1  glucocorticoid receptor isoform gamma

   See identical proteins and their annotated locations for NP_001019265.1

   Status: REVIEWED

   Description Transcript Variant: This variant (7) uses an alternate in-frame donor splice site at one of the coding exons compared to variant 1. This results in an isoform (gamma) that is 1 aa longer than isoform alpha. The insertion of an additional amino acid (arginine) in the DNA binding domain has been reported to decrease transcriptional activation by the glucocorticoid receptor (PMID:10566686). Source sequence(s) AC004782, AC091925, U01351 Consensus CDS CCDS34258.1 UniProtKB/TrEMBL A0A5B9RIM3, E5KQF6 Related ENSP00000231509.3, ENST00000231509.7 Conserved Domains (3) summary cd07076Location:532 → 778 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 495 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

8. NM_001204258.2 → NP_001191187.1  glucocorticoid receptor isoform alpha-B

   Status: REVIEWED

   Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-B, also known as GR-B) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 571-573). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL A0A5B9RIM3 Conserved Domains (3) summary cd07076Location:505 → 751 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:391 → 468 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 375 GCR; Glucocorticoid receptor

9. NM_001204259.2 → NP_001191188.1  glucocorticoid receptor isoform alpha-C1

   Status: REVIEWED

   Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C1, also known as GR-C1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 748-750). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL A0A5B9RIM3 Conserved Domains (3) summary cd07076Location:446 → 692 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:332 → 409 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 316 GCR; Glucocorticoid receptor

10. NM_001204260.2 → NP_001191189.1  glucocorticoid receptor isoform alpha-C2

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C2, also known as GR-C2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 760-762). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL A0A5B9RIM3 Conserved Domains (3) summary cd07076Location:442 → 688 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:328 → 405 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 312 GCR; Glucocorticoid receptor

11. NM_001204261.2 → NP_001191190.1  glucocorticoid receptor isoform alpha-C3

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternative in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-C3, also known as GR-C3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 784-786). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL A0A5B9RIM3 Conserved Domains (3) summary cd07076Location:434 → 680 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:320 → 397 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 304 GCR; Glucocorticoid receptor

12. NM_001204262.2 → NP_001191191.1  glucocorticoid receptor isoform alpha-D1

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D1, also known as GR-D1) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1438-1440). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL B7Z7I2 Conserved Domains (3) summary cd07076Location:216 → 462 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:102 → 179 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 86 GCR; Glucocorticoid receptor

13. NM_001204263.2 → NP_001191192.1  glucocorticoid receptor isoform alpha-D2

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D2, also known as GR-D2) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1483-1485). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL B7Z7I2 Conserved Domains (3) summary cd07076Location:201 → 447 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:87 → 164 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 71 GCR; Glucocorticoid receptor

14. NM_001204264.2 → NP_001191193.1  glucocorticoid receptor isoform alpha-D3

    Status: REVIEWED

    Description Transcript Variant: This variant (1) encodes multiple functional isoforms resulting from the use of alternate in-frame, translation initiation codons (PMID:15866175). This RefSeq represents a shorter isoform (alpha-D3, also known as GR-D3) compared to isoform alpha, and is derived from the use of a downstream AUG (at nt 1498-1500). Source sequence(s) AC004782, AC091925, CA425706, U01351, X03225 UniProtKB/TrEMBL B7Z7I2 Conserved Domains (3) summary cd07076Location:196 → 442 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:82 → 159 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:1 → 66 GCR; Glucocorticoid receptor

15. NM_001204265.2 → NP_001191194.1  glucocorticoid receptor isoform GR-P

    Status: REVIEWED

    Description Transcript Variant: This variant (8, also known as GR-P) is missing 2 exons from the 3' end, and has a different 3' end compared to variant 1. This results in an isoform (GR-P) with a shorter and unique C-terminus compared to isoform alpha. The function of the encoded protein is not known, however, this variant is highly expressed in cells that are resistant to glucocorticoids, and may act to modulate glucocorticoid responsiveness (PMIDs:7796394, 11358809). Source sequence(s) AA737284, AC091925, BF244382, U01351, U25029 UniProtKB/TrEMBL F5ATB8 Conserved Domains (3) summary cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor cl11397Location:531 → 674 NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

16. NM_001364180.2 → NP_001351109.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Related ENSP00000540553.1, ENST00000870494.1 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

17. NM_001364181.2 → NP_001351110.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Related ENSP00000540558.1, ENST00000870499.1 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

18. NM_001364182.1 → NP_001351111.1  glucocorticoid receptor isoform alpha

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925 Consensus CDS CCDS4278.1 UniProtKB/Swiss-Prot A0ZXF9, B0LPG8, D3DQF4, F5ATB7, P04150, P04151, Q53EP5, Q6N0A4 UniProtKB/TrEMBL A0A5B9RIM3, F1D8N4 Conserved Domains (3) summary cd07076Location:531 → 777 NR_LBD_GR; Ligand binding domain of the glucocorticoid receptor, a member of the nuclear receptor superfamily cd07172Location:417 → 494 NR_DBD_GR_PR; DNA-binding domain of glucocorticoid receptor (GR) is composed of two C4-type zinc fingers pfam02155Location:26 → 401 GCR; Glucocorticoid receptor

19. NM_001364183.2 → NP_001351112.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925, BX648553 Consensus CDS CCDS34258.1 UniProtKB/TrEMBL A0A5B9RIM3, E5KQF6 Related ENSP00000422518.1, ENST00000504572.5

20. NM_001364184.2 → NP_001351113.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925 Consensus CDS CCDS34258.1 UniProtKB/TrEMBL A0A5B9RIM3, E5KQF6 Related ENSP00000540554.1, ENST00000870495.1

21. NM_001364185.1 → NP_001351114.1  glucocorticoid receptor isoform gamma

    Status: REVIEWED

    Source sequence(s) AC004782, AC091925 Consensus CDS CCDS34258.1 UniProtKB/TrEMBL A0A5B9RIM3, E5KQF6

RNA

1. NR_157096.2 RNA Sequence

   Status: REVIEWED

   Source sequence(s) AC004782, AC091925, AK302050

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

This section includes genomic Reference Sequences (RefSeqs) from all assemblies on which this gene is annotated, such as RefSeqs for chromosomes and scaffolds (contigs) from both reference and alternate assemblies. Model RNAs and proteins are also reported here.

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

   Range 143277931..143435512 complement Download GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

1. NC_060929.1 Alternate T2T-CHM13v2.0

   Range 143809293..143966896 complement Download GenBank, FASTA, Sequence Viewer (Graphics)

Related sequences

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Nucleotide		Protein
Heading	Accession and Version

Protein Accession	Links
	GenPept Link	UniProtKB Link
P04150.1	GenPept	UniProtKB/Swiss-Prot:P04150

Additional links

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Supplemental Content

Table of contents

• Summary
• Genomic context
• Genomic regions, transcripts, and products
• Expression
• Bibliography
• Phenotypes
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• HIV-1 interactions
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