Oral Contraceptive-alpha-tocopherol Interrelationships - PubMed

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Abstract

PIP: After observing that some of the side effects of the administration of oral contraceptive drugs to rats resemble those resulting from vitamin E deficiency, a possibility of an increased requirement for vitamin E during oral contraceptive therapy was considered. 4 groups each of 22 female weanling rats were placed on a 15% stripped corn oil diet adequate in all required nutrients except alpha-tocopherol. Group T had .01%, d,1-alpha-tocopheryl acetate incorporated into the diet; Group B had .05% butylated hydroxytoluene (BHT); Group N and NT had no additives. After 10 weeks when daily dosing with Enovid E (.052 mg in .1 ml propylene glycol) was initiated, Group NT was changed over to the tocopherol containing diet. The dosing continued for 4 days for half of the animals and for 28 days for the other half (Groups E) at which time the animals were sacrificed. 8 animals in each group served as a control and received the propylene glycol carrier only (Groups C). During the short experimental period, most of the animals lost weight whereas the long period of dosing resulted in lower gains in the vitamin E deficient than in E sufficient rats. Results showed that the effects of an oral contraceptive were less pronounced in E deficient rats. Lowering of plasma tocopherol levels was observed in rats receiving the drug. The vitamin E deficiency and the stress induced by the administration of an oral contraceptive were definitely not synergistic. It follows then that oral contraceptives do not aggravate biochemical changes when tocopherol status is inadequate.

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1. 1. Obstet Gynecol. 1969 Oct;34(4):530-5 - PubMed
2. 1. JAMA. 1972 Sep 18;221(12):1371-4 - PubMed
3. 1. J Nutr. 1969 Aug;98(4):390-4 - PubMed
4. 1. Proc Natl Acad Sci U S A. 1969 Nov;64(3):1128-37 - PubMed
5. 1. J Lipid Res. 1971 May;12(3):306-12 - PubMed

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