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P-AMINOPHENOL HYDROCHLORIDE IWL2N22RFY
Possibly Marketed Outside US Source: SALON CODE Glam Hair Color Glam Brown by Daolcosmetic Co.,ltd
Source URL: https://www.drugbank.ca/drugs/DB14144
First approved in 2013 Source: BEAUTIFUL WOMANS HAIR LOVES COLORFUL BUBBLES HAIR DYE 5N NATURAL BROWN by Modlina Cosmetics Co., Ltd
Source URL: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2b4e78e6-19cb-4d12-b069-52607d883334
P-AMINOPHENOL HYDROCHLORIDE IWL2N22RFY
Possibly Marketed Outside US Source: SALON CODE Glam Hair Color Glam Brown by Daolcosmetic Co.,ltd
Source URL: https://www.drugbank.ca/drugs/DB14144
First approved in 2013 Source: BEAUTIFUL WOMANS HAIR LOVES COLORFUL BUBBLES HAIR DYE 5N NATURAL BROWN by Modlina Cosmetics Co., Ltd
Source URL: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=2b4e78e6-19cb-4d12-b069-52607d883334
Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H7NO.ClH |
| Molecular Weight | 145.587 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI ![Structure of P-AMINOPHENOL HYDROCHLORIDE]( "Structure of P-AMINOPHENOL HYDROCHLORIDE")
SHOW STEREO... HIDE STEREO... SMILES
Cl.NC1=CC=C(O)C=C1
InChI
InChIKey=RVGOBWDGAVAVPJ-UHFFFAOYSA-N InChI=1S/C6H7NO.ClH/c7-5-1-3-6(8)4-2-5;/h1-4,8H,7H2;1H
HIDE SMILES / InChI | Molecular Formula | ClH |
| Molecular Weight | 36.461 |
| Charge | 0 |
| Count |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | C6H7NO |
| Molecular Weight | 109.1259 |
| Charge | 0 |
| Count |
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/18811827 | https://www.ncbi.nlm.nih.gov/pubmed/1713494 | (1994) Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, page 189, retrieved from: https://books.google.ru/books?id=rzJRFA-GePgC | https://www.ncbi.nlm.nih.gov/pubmed/23393911 | https://www.ewg.org/skindeep/ingredient/704384/P-AMINOPHENOL/#.Wm3JS65l-pp
p-Aminophenol is an active metabolite of paracetamol. p-Aminophenol is conjugated with arachidonic acid by fatty acid amide hydrolase to form AM404. AM404 exerts effect through cannabinoid receptors. p- Aminophenol is a nephrotoxic metabolite of paracetamol and phenacetin. It causes acute renal proximal tubular necrosis after administration to rats. p-Aminophenol may cause skin sensitization, dermatitis. p-Aminophenol is a synthetic dye used in hair coloring.
Approval Year
2013
589 Targets
Targets
| Primary Target | Pharmacology | Condition | Potency | | Arylamine N-acetyltransferase 14Target ID: CHEMBL5101Sources: https://www.ncbi.nlm.nih.gov/pubmed/10692486 | Substrate661 |
| Arylamine N-acetyltransferase 14Target ID: CHEMBL5101Sources: https://www.ncbi.nlm.nih.gov/pubmed/10692486 | Substrate661 |
Conditions
Conditions
| Condition | Modality | Targets | Highest Phase | Product | | Unknown2596 |
PubMed
PubMed
| Title | Date | PubMed | | A new dynamic electrochemical transduction mechanism for interdigitated array microelectrodes. | 2004-12 | 15570369 |
| Degradation of 4-nitrophenol by the lignin-degrading basidiomycete Phanerochaete chrysosporium. | 2004-12 | 15448939 |
| Reactions of arylamine and aminophenol derivatives, and riboflavin with organic radicals. | 2004-11 | 15621695 |
| Toxic effects of aminophenols on aquatic life using the zebrafish embryo test and the comet assay. | 2004-10 | 15389326 |
| Microchip capillary electrophoresis with a boron-doped diamond electrochemical detector for analysis of aromatic amines. | 2004-09 | 15349943 |
| Pharmacophore based synthesis of 3-chloroquinoxaline-2-carboxamides as serotonin3 (5-HT3) receptor antagonist. | 2004-09 | 15340227 |
| Poly(dimethylsiloxane) microchip capillary electrophoresis with electrochemical detection for rapid measurement of acetaminophen and its hydrolysate. | 2004-08 | 15221194 |
| The measurement of alkaline phosphatase at nanomolar concentration within 70 s using a disposable microelectrochemical transistor. | 2004-08 | 15219247 |
| The demonstration of an enhanced microelectrochemical transistor for measurements in neutral solution at low analyte concentration. | 2004-08 | 15219241 |
| Spectrophotometric determination of paracetamol with microwave assisted alkaline hydrolysis. | 2004-07 | 15248961 |
| Scanning electrochemical microscopy of quinoprotein glucose dehydrogenase. | 2004-06-01 | 15167795 |
| Hair dye contact allergy: quantitative exposure assessment of selected products and clinical cases. | 2004-06 | 15274724 |
| Bead-based immunoassays with microelectrode detection. | 2004-06 | 15118802 |
| Bead-based electrochemical immunoassay for bacteriophage MS2. | 2004-05-15 | 15144178 |
| Microbead-based electrochemical immunoassay with interdigitated array electrodes. | 2004-05-15 | 15113686 |
| Synthesis and biological activity of novel retinamide and retinoate derivatives. | 2004-05 | 15133197 |
| Hapten-directed targeting to single-chain antibody receptors. | 2004-05 | 15044963 |
| Toxicity and human health risk of hair dyes. | 2004-04 | 15019177 |
| Flow injection determination of p-aminophenol at trace level using inhibited luminol-dimethylsulfoxide-NaOH-EDTA chemiluminescence. | 2004-03-25 | 15644248 |
| Electrical detection of viral DNA using ultramicroelectrode arrays. | 2004-02-01 | 14750864 |
| Express detection of nonylphenol in water samples by fluorescence polarization immunoassay. | 2004-02 | 14673557 |
| Electric chips for rapid detection and quantification of nucleic acids. | 2004-01-15 | 14683637 |
| [Kinetics and mechanism of aniline oxidation with chlorine dioxide in water]. | 2004-01 | 15330430 |
| Effect of unlabeled helper probes on detection of an RNA target by bead-based sandwich hybridization. | 2004-01 | 14740494 |
| Automated spectrophotometric assay for urine p-aminophenol by an oxidative coupling reaction. | 2004 | 15487710 |
| Kinetics of aniline oxidation with chlorine dioxide. | 2004 | 15137646 |
| Toxicological detection of the new designer drug 1-(4-methoxyphenyl)piperazine and its metabolites in urine and differentiation from an intake of structurally related medicaments using gas chromatography-mass spectrometry. | 2003-12-25 | 14643514 |
| Oxidation-reduction potential as a control variable for the anaerobic stage during anaerobic-aerobic p-nitrophenol degradation. | 2003-12-06 | 14656162 |
| First enantiospecific total synthesis of the antitubercular marine natural product pseudopteroxazole. Revision of assigned stereochemistry. | 2003-11-05 | 14583045 |
| Enzyme-amplified electrochemical detection of DNA using electrocatalysis of ferrocenyl-tethered dendrimer. | 2003-11-01 | 14588003 |
| A potential biomarker of kidney damage identified by proteomics: preliminary findings. | 2003-08-29 | 12944177 |
| Determination of 4-aminophenol impurities in multicomponent analgesic preparations by HPLC with amperometric detection. | 2003-08-08 | 12899997 |
| Synthesis and activity of novel benzoxazole derivatives of mannopeptimycin glycopeptide antibiotics. | 2003-08-04 | 12852976 |
| Immobilized enzyme-linked DNA-hybridization assay with electrochemical detection for Cryptosporidium parvum hsp70 mRNA. | 2003-08-01 | 14572058 |
| Evolution of catabolic pathways for synthetic compounds: bacterial pathways for degradation of 2,4-dinitrotoluene and nitrobenzene. | 2003-08 | 12750857 |
| Enhancement of antioxidant activity of p-alkylaminophenols by alkyl chain elongation. | 2003-07-31 | 12837535 |
| Continuous biotransformation and removal of nitrophenols under denitrifying conditions. | 2003-07 | 12767298 |
| Validation of a method for quantification of ketobemidone in human plasma with liquid chromatography-tandem mass spectrometry. | 2003-06-15 | 12742125 |
| Unbiased spectrophotometric method for estimating phenol or o-cresol in unknown water samples. | 2003-06 | 12732922 |
| Generation of ligand conformations in continuum solvent consistent with protein active site topology: application to thrombin. | 2003-04-10 | 12672230 |
| Metalloantimalarials: targeting of P. falciparum strains with novel iron(III) and gallium(III) complexes of an amine phenol ligand. | 2003-04-07 | 12665363 |
| Sorption and diffusion of phenols onto well-defined ordered nanoporous monolithic silicas. | 2003-04-01 | 12742049 |
| The use of thermal lensing for the determination of pyrogens. | 2003-04 | 12733016 |
| Reversible and irreversible inhibitory activity of succinic and maleic acid derivatives on acetylcholinesterase. | 2003-04 | 12694883 |
| Dlf complexes with uniform coordination geometry: structural and magnetic properties of an LnNi2 core supported by a heptadentate amine phenol ligand. | 2003-03-10 | 12611525 |
| Synthesis of 11C-amides using [11C]carbon monoxide and in situ activated amines by palladium-mediated carboxaminations. | 2003-02-07 | 12926257 |
| Immobilizing a single pybox ligand onto a library of solid supports. | 2003 | 14761160 |
| [Research into simultaneous spectrophotometric determination of components in cough syrup by principal component regression method]. | 2002-06 | 12938324 |
| Renal PGE2 production in the human and rat following phenacetin, acetaminophen and p-aminophenol. | 2002 | 14632321 |
| Effects of alternative carbon sources on biological transformation of nitrophenols. | 2002 | 12688587 |
Patents
Patents
JP1004635A
4 JP2000026572A
3 JP2000103975A
6 JP2000248077A
3 JP2001183835A
3 JP2001192500A
3 JP2001342238A
3 JP2002088066A
3 JP2002533511A
3 JP2003128513A
3 JP2005029590A
6 JP2005082628A
3 JP2005306866A
3 JP2005527113A
4 JP2006008642A
3 JP2006028082A
3 JP2006278197A
3 JP2006321834A
3 JP2006523256A
8 JP2007084524A
3 JP2007308427A
4 JP2008214479A
3 JP2009263324A
5 JP2011529977A
3 JP2012500104A
108 JP3016599B2
3 JP4550838B2
3 JP4728230B2
5 JP4820369B2
7 JPH01174526A
3 JPH01319528A
3 JPH0211551A
3 JPH02170862A
3 JPH02188556A
3 JPH0219368A
3 JPH02232224A
3 JPH02240138A
3 JPH0269448A
3 JPH03112946A
5 JPH03127762A
5 JPH03177419A
3 JPH04108824A
3 JPH04154860A
3 JPH0496924A
3 JPH05156007A
3 JPH05170902A
4 JPH05174621A
3 JPH05221937A
3 JPH0551450A
3 JPH06219999A
3 JPH06228303A
3 US3079435 A
3 Sample Use Guides
In Vivo Use Guide UnknownRoute of Administration:
Unknown In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/21771276 Concentrations of p-aminophenol from 1 to 100 μg/ml produced significant (p < 0.05) loss of mouse cortical neuron viability at 24 hr compared to the controls.
| Substance Class | Chemical Created by admin on Mon Mar 31 19:23:46 GMT 2025 Edited by admin on Mon Mar 31 19:23:46 GMT 2025 |
| Record UNII | IWL2N22RFY |
| Record Status | Validated (UNII) |
| Record Version | {{v}} |
| Name | Type | Language |
| P-AMINOPHENOL HYDROCHLORIDE | Locators: HSDB Sources: | | Common Name | English |
| P-AMINOPHENOL HCL | Locators: INCI Naming Organization: INCI Sources: | | Preferred Name | English |
| | Brand Name | English |
| PHENOL, 4-AMINO-, HYDROCHLORIDE | Sources: | | Systematic Name | English |
| 4-AMINOPHENOL HYDROCHLORIDE | Source: | | Systematic Name | English |
| 4-HYDROXYANILINIUM CHLORIDE | Sources: | | Systematic Name | English |
| | Brand Name | English |
| P-HYDROXYANILINE HYDROCHLORIDE | Sources: | | Common Name | English |
| PHENOL, 4-AMINO-, HYDROCHLORIDE (1:1) | Sources: | | Systematic Name | English |
| P-AMINOPHENOL HYDROCHLORIDE [HSDB] | Sources: | | Common Name | English |
| Code System | Code | Type | Description |
| | 2151 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | C026729 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | 5828 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | IWL2N22RFY Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | DTXSID6058760 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | DBSALT002745 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | 200-122-6 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| | 51-78-5 Created by admin on Mon Mar 31 19:23:46 GMT 2025 , Edited by admin on Mon Mar 31 19:23:46 GMT 2025 | PRIMARY |
| Related Record | Type | Details |
R7P8FRP05V  p-Aminophenol | | PARENT -> SALT/SOLVATE |
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