Top 15+ P.g12c hay nhất
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1.Sotorasib For Lung Cancers With KRAS P.G12C Mutation | NEJM
24 thg 6, 2021 · The KRAS p.G12C mutation favors the active form of KRAS and results in abnormally high concentrations of GTP-bound KRAS, leading to ...
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2.Sotorasib For Lung Cancers With KRAS P.G12C Mutation - PubMed
24 thg 6, 2021 · Background: Sotorasib showed anticancer activity in patients with KRAS p.G12C-mutated advanced solid tumors in a phase 1 study, and particularly ...
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3.KRAS P.G12C Mutation Occurs In 1% Of EGFR-mutated Advanced ...
1 thg 10, 2021 · KRAS p.G12C mutation occurs in 1% of EGFR-mutated advanced non-small-cell lung cancer patients progressing on a first-line treatment with a ...
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4.Mutation Overview Page KRAS - P.G12C ( Substitution - COSMIC
Gene name: KRAS ; AA mutation. p.G12C (Substitution - Missense, position 12, G➞C) ; CDS mutation. c.34G>T (Substitution, position 34, G➞T) ; SNP: No ; Nucleotides ... Overview · Tissue distribution · Samples
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5.Original Research KRAS P.G12C Mutation Occurs In 1% Of EGFR ...
G12C mutation have reported encouraging results. ... This mutation, which causes the replacement of glycine by cysteine at 12 position, promotes active state of ...
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6.P.G12C KRAS Mutation Prevalence In Non-small Cell Lung Cancer
The KRAS exon 2 p. G12C mutation in patients with lung adenocarcinoma has been increasing in relevance due to the development and effectiveness of new ...
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7.First Data For Sotorasib In Patients With Pancreatic Cancer With KRAS ...
17 thg 2, 2022 · Background: KRAS mutation is present in 90% of pancreatic ductal adenocarcinomas with p.G12C accounting for 1% to 2% of these mutations.
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8.KRAS P.G12C Mutation Occurs In 1% Of EGFR ... - ESMO Open
1 thg 10, 2021 · KRAS is mutated in ∼30% of non-small-cell lung cancer (NSCLC) but it has also been identified as one of the mechanisms underlying ...
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9.Prevalence Of KRAS P.(G12C) In Stage IV NSCLC Patients In The ...
24 thg 3, 2022 · Prevalence for any KRAS mutations in codon 12/13/61/146 was 39.1%. KRAS p.(G12C) was detected in 15.5% of all non-squamous NSCLC cases ...
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10.Real-World Data Show Unmet Need In KRAS P.G12C-Mutated ...
4 thg 5, 2022 · Treatment patterns are generally similar for patients with metastatic colorectal cancer, whether or not they have KRAS p.G12C mutations.
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11.KRAS G12C Research Could Bring Hope To Patients With Cancer
5 thg 10, 2019 · KRAS G12C is an oncogenic driver mutation in multiple cancer types ... KRAS mutations play a role in some of the most common and deadly carcinomas ...
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12.Sotorasib Activity In Subjects With Advanced Solid Tumors With ...
4 thg 12, 2019 · To evaluate the safety and tolerability of sotorasib administered in investigational regimens in adult participants with KRAS p.G12C mutant ...
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13.Real-World Study Of Characteristics And Treatment Outcomes ...
26 thg 4, 2022 · G12C disease, this article describes clinicopathologic characteristics, trea. ... KRAS p.G12C, metastatic colorectal cancer, retrospective.
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14.P52.03 Efficacy Of Sotorasib In KRAS P.G12C-Mutated NSCLC With ...
The phase 1/2 CodeBreaK 100 trial evaluated sotorasib in patients with pretreated advanced non-small cell lung cancer (NSCLC) harboring KRAS p.G12C.
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15.Activity Of The KRAS G12C Inhibitor Sotorasib In ... - The ASCO Post
30 thg 9, 2020 · As stated by the investigators, “No therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% ...
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