P120-Catenin: A Novel Regulator Of Innate Immunity And Inflammation

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Abstract

p120-Catenin is the prototypic member of a subfamily of armadillo repeat domain proteins. Like its structural homologues, β- and γ-catenin, p120-catenin is an essential component of adherens junctions in endothelial cells and other polarized adherent cells. p120-Catenin binds directly to the cytoplasmic domain of cadherin and contributes to the regulation of cell-cell junctional integrity. Studies have demonstrated that p120-catenin plays important roles in cell-cell adhesion, embryonic development, cell proliferation and polarity, tumor cell migration, and cancer progression. However, recent insights have generated an entirely new perspective, suggesting that p120-catenin is implicated in the anti-inflammatory responses in the absence and presence of infection. This review summarizes the present knowledge and recent progress toward elucidating the novel role of p120-catenin in the regulation of innate immunity and inflammation.

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Figures

FIGURE 1

FIGURE 1

The structure of p120-catenin.

FIGURE 1

The structure of p120-catenin.

FIGURE 1 The structure of p120-catenin.
FIGURE 2

FIGURE 2

TLR4 signaling pathways regulating inflammation.…

FIGURE 2

TLR4 signaling pathways regulating inflammation. Abbreviations: AP-1, activator protein 1; cAMP response element-binding…

FIGURE 2 TLR4 signaling pathways regulating inflammation. Abbreviations: AP-1, activator protein 1; cAMP response element-binding protein; ERK, extracellular-signal-regulated kinases; IκB, inhibitor of NF-κB; IKK, IκB kinase; IRF 3, interferon regulatory factor 3; IRAK-1 and IRAK-4, interleukin-1 receptor-associated kinase 1 and 4; JNK, Jun N-terminal protein kinase; LPS, lipopolysaccharide; MAPK, mitogen-activated protein kinase; MyD88, myeloid differentiation factor; NF-κB, nuclear factor-κB; TLR, Toll-like receptor; TAK1, transforming growth factor-β-activated kinase 1; TRAF6, TNF receptor-associated factor 6; TRIF, TIR-domain-containing adaptor protein inducing interferon-β.
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References

    1. Carnahan RH, Rokas A, Gaucher EA, Reynolds AB. The molecular evolution of the p120-catenin subfamily and its functional associations. PLoS One. 2010;5:e15747. - PMC - PubMed
    1. McCrea PD, Park JI. Developmental functions of the p120-catenin subfamily. Biochim Biophys Acta. 2007;1773:17–33. - PubMed
    1. Reynolds AB, Roesel DJ, Kanner SB, Parsons JT. Transformation specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol. 1989;9:629–38. - PMC - PubMed
    1. Reynolds AB, Herbert L, Cleveland JL, Berg ST, Gaut JR. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo. Oncogene. 1992;7:2439–45. - PubMed
    1. Reynolds AB, Daniel J, McCrea PD, Wheelock MJ, Wu JJ, Zhang Z. Identification of a new catenin: the tyrosine kinase substrate p120cas associates with E-cadherin complexes. Mol Cell Biol. 1994;14:8333–42. - PMC - PubMed
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