Patterning Cells And Microparticles Using Standing Surface Acoustic ...

Acoustic tweezers: patterning cells and microparticles using standing surface acoustic waves (SSAW)†

Jinjie Shi,a Daniel Ahmed,a Xiaole Mao,ab Sz-Chin Steven Lin,a Aitan Lawita and Tony Jun Huang*ab Author affiliations

* Corresponding authors

a Department of Engineering Science and Mechanics, The Pennsylvania State University, University Park, PA, USA E-mail: [email protected] Fax: +1 814-865-9974 Tel: +81 14-863-4209

b Department of Bioengineering, The Pennsylvania State University, University Park, Pennsylvania, USA

Abstract

Here we present an active patterning technique named “acoustic tweezers” that utilizes standing surface acoustic wave (SSAW) to manipulate and pattern cells and microparticles. This technique is capable of patterning cells and microparticles regardless of shape, size, charge or polarity. Its power intensity, approximately 5 × 105 times lower than that of optical tweezers, compares favorably with those of other active patterning methods. Flow cytometry studies have revealed it to be non-invasive. The aforementioned advantages, along with this technique's simple design and ability to be miniaturized, render the “acoustic tweezers” technique a promising tool for various applications in biology, chemistry, engineering, and materials science.

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