Phytomenadione: Indication, Dosage, Side Effect, Precaution - MIMS

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Phytomenadione This information is not country-specific. Please refer to the Malaysia prescribing information. Generic Medicine Info

Indications and Dosage OralOver-anticoagulationAdult: 2.5-25 mg. Frequency and amount of subsequent doses are given according to prothrombin time (PT) response or clinical condition.Elderly: Initiate at the lower end of dosing range.OralVitamin K deficiency bleeding in neonatesChild: As prophylaxis: 1-2 mg at birth, followed by 2 mg at 4-7 days of age, and a further 2 mg after 1 month of birth.ParenteralVitamin K deficiency bleeding in neonatesChild: As prophylaxis: For healthy neonates: 1 mg via IM inj at birth. For preterm neonates: <2.5 kg: 0.4 mg/kg via IM or IV inj; ≥2.5 kg: 1 mg via IM or IV inj. Dose is given soon after birth. The amount and frequency of further doses are based on coagulation status. As treatment: Initially, 1 mg via SC/IM/IV with or without prothrombin complex concentrate (PCC) or fresh frozen plasma (FFP).ParenteralOver-anticoagulationAdult: For severe cases: 5-10 mg as SC or slow IV inj over at least 30 seconds with PCC or FFP. Max: 40 mg in 24 hours. For patients with INR between 5-9: 0.5-1.0 mg IV. For patients with INR >9: 1.0 mg IV. For purposes of reversal prior to surgery: 5 mg IV.Elderly: Initiate at the lower end of the dosing range.Child: For partial reversal: >13 kg: 0.03 mg/kg via IV inj. For complete reversal: >1.6 kg: 0.25-0.30 mg/kg via IV inj.

What are the brands available for Phytomenadione in Malaysia? Kisan Konakion

Administration Phytomenadione May be taken with or without food.

Incompatibility IV: Precipitation may occur with Na chloride solution.

Contraindications Hypersensitivity.

Special Precautions Patient with mechanical heart valves. Hepatic impairment. Elderly. Children. Pregnancy and lactation.

Adverse Reactions Cardiac disorders: Dyspnoea. Gastrointestinal disorders: Taste disturbance. Injury, poisoning and procedural complications: Irritation, phlebitis, schleroderma-like lesions; erythematous, indurated, and pruritic plaques (repeated inj). Investigations: Rapid or weak pulse. Nervous system disorders: Dizziness. Skin and subcutaneous tissue disorders: Sweating. Vascular disorders: Hypotension, cyanosis, flushing. Potentially Fatal: Rarely, anaphylactoid reactions (IM/IV).

Pregnancy Category (US FDA) IM/IV/Parenteral/SC: C

Monitoring Parameters Regularly monitor PT, INR and vitamin K dependent clotting factors; hypersensitivity reactions.

Drug Interactions Antagonises the effect of coumarin anticoagulants.

Action Description: Mechanism of Action: Phytomenadione (vitamin K1), a naturally occurring compound, promotes hepatic synthesis of clotting factors (II, VII, IX, X) and of coagulation inhibitors (protein C and S). It is used to prevent and treat haemorrhages related to vitamin K deficiency.Pharmacokinetics: Absorption: Absorbed from the gastrointestinal tract in the presence of bile salts. Readily absorbed via IM inj.Distribution: Accumulates in the liver and stored in the body for short periods of time. Plasma protein binding: Up to 90%, to lipoproteins.Metabolism: Rapidly metabolised in the liver into polar metabolites (e.g. phytomenadione-2,3-epoxide).Excretion: Via urine and faeces (as glucuronide and sulfate conjugates). Plasma elimination half-life: 2-3 hours.

Chemical Structure Source: National Center for Biotechnology Information. PubChem Database. Vitamin K1, CID=5284607, https://pubchem.ncbi.nlm.nih.gov/compound/Vitamin-K1 (accessed on Jan. 22, 2020)

Storage Store between 20-25°C. Protect from light.

MIMS Class Haemostatics

ATC Classification B02BA01 - phytomenadione ; Belongs to the class of vitamin K. Used in the treatment of hemorrhage.

References Anon. Phytonadione. Lexicomp Online. Hudson, Ohio. Wolters Kluwer Clinical Drug Information, Inc. https://online.lexi.com. Accessed 07/11/2017. Aquamephyton Injection, Emulsion (Teligent Pharma, Inc.). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/11/2017. Buckingham R (ed). Vitamin K Substances. Martindale: The Complete Drug Reference [online]. London. Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/11/2017. Joint Formulary Committee. Phytomenadione. British National Formulary [online]. London. BMJ Group and Pharmaceutical Press. https://www.medicinescomplete.com. Accessed 07/11/2017. McEvoy GK, Snow EK, Miller J et al (eds). Phytonadione. AHFS Drug Information (AHFS DI) [online]. American Society of Health-System Pharmacists (ASHP). https://www.medicinescomplete.com. Accessed 07/11/2017. Mephyton Tablet (Carilion Materials Management). DailyMed. Source: U.S. National Library of Medicine. https://dailymed.nlm.nih.gov/dailymed/. Accessed 07/11/2017.

Disclaimer: This information is independently developed by MIMS based on Phytomenadione from various references and is provided for your reference only. Therapeutic uses, prescribing information and product availability may vary between countries. Please refer to MIMS Product Monographs for specific and locally approved prescribing information. Although great effort has been made to ensure content accuracy, MIMS shall not be held responsible or liable for any claims or damages arising from the use or misuse of the information contained herein, its contents or omissions, or otherwise. Copyright © 2026 MIMS. All rights reserved. Powered by MIMS.com Advertisement Advertisement Advertisement Advertisement Advertisement Advertisement Related Diseases

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