Positive Selection On Hemagglutinin And Neuraminidase Genes Of ...

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Protein

Position1

P-value

Amino acid polymorphism2

   

Pandemic 2009 strains

Seasonal human strains

HA

34BT

0.00286

E1886/G2/X2/K1

E1404

 

39

0.00054

G1887/E3/R1

G1404

 

86B

0.00233

D1856/G31/N2/Y1/E1

E1383/K19/G1/Q1

 

94B

0.00014

D1885/N4/E1/X1

Y769/H574/D38/N19/Q2/A1/R1

 

153BT

0.00786

K1891

G1132/E202/R28/K20/X18/V4

 

160BG

0.00073

K1890/E1

N1345/K27/X12/S7/T7/D2/E2/A1/I1

 

187BR

0.00445

D1884/G5/X2

D1072/X135/N132/V30/E23/G9/A2/I1

 

197

0.00073

A1851/T23/S17

A1401/T3

 

202B

0.00318

G1886/X4/W1

V1378/L17/A5/M4

 

203

0.00828

T1341/S542/X7/A1

S1392/T10/F1/X1

 

224B

0.00973

E1885/Q1/X5

E1342/A45/H5/P5/K4/T2/S1

 

234

0.00628

V1883/I7/L1

L1404

 

237B

0.00445

G1890/X1

G1379/R19/E6

 

250T

0.00002

V1884/I4/A2/L1

A1404

 

282

0.00653

P1872/L10/S7/T1/X1

P1404

 

302B

0.00098

K1880/E8/N1/T1/R1

E1403/G1

 

339

0.00174

G1888/R2/E1

G1404

 

374

0.00550

E1608/K275/G8

G1398/R4

 

391

0.00564

T1888/A2/I1

T1404

 

399

0.00303

H1890/X1

K1383/N16/R3/E1/T1

 

430T

0.00605

E1889/D1/K1

E1404

 

473T

0.00803

N1890/D1

D1001/N403

 

527T

0.00513

V1873/I12/A2/L2/X2

L1403/V1

 

541T

0.00052

G1866/W12/H6/M3/Y1/-3

G1404

NA

2

0.00001

N1313/-79/I2/S1/X1

N1532/-200/K3

 

6

0.00009

K1350/-42/N3/R3

K1634/R14/-87

 

35

0.00151

S1392/G2/C1/I1/V1

S1733/N1/G1

 

52TG

0.00510

S1397

R1686/K17/S17/N9/G4/X1/-1

 

254

0.00188

K1396/X1

K1581/R154

 

257

0.00119

R1388/K8/X1

K1735

  1. 1In this column, B indicates that the site lies in the B-cell antigenic regions [18]. G means that it is a potential glycosylation site. T indicates that the site lies in the T-cell antigenic regions [19]. R indicates that it is a receptor-binding site [11]. We use the same numbering strategy for HA as Deem and Pan [18] and start numbering from the amino acids DTLC. The NA numbering starts from MNPN.
  2. 2In these columns, capital letters stand for amino acids and numbers following them indicate the number of times they occur in the alignment. X indicates codons that are not translated properly.
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Virology Journal

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