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December Molecule of the Month

FOXP3
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Latest Entries
As ofWed Dec 24 2025
9XQR
Cryo-EM structure of P1X1 in complex with BTFA

9Q3T
Crystal Structure of WT HIV-1 Protease (NL4-3) with Inhibitor NR03-92

9HQB
1-Epi-Cubenol Synthase from Nonomuraea coxensis (NcECS) in complex with 2,3-DHFPP

9OQI
Human pannexin 1 channel with 20 mM ATP

9IBP
VCA0144 from Vibrio cholerae

9X45
Cryo-EM structure of renal amyloid fibril from an immunoglobulin light chain amyloidosis patient in polymorph A

9HO4
Crystal Structure of the Human Frataxin protein in complex with a tailored Camelid Nanobody 6B1

9HNR
a5b3 GABAA Receptor in 1 a5 to 4 b3 stoichiometry in desensitized state

9GXT
C. thermocellum UvrA in complex with DNA with a fluorescein modification and AMPPNP (ATP-bound conformation 1)

9MPX
Crystal structure of RM014, a macaque-derived HIV V2-apex-targeting antibody from ApexGT6 immunization
Features & Highlights

Milestone: >20,000 Structures Deposited to the PDB in 2025
wwPDB has received a record number of depositions this year

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Register Now for Webinar: Exploring the Workhorses of Biotechnology
On November 6, learn how to use RCSB.org to analyze plastic-degrading enzymes

Coming Soon: Remediation of Metalloprotein-containing PDB Entries and CCDs
Existing polyatomic metal containing PDB entries and CCDs will be updated to make metalloprotein structures findable and reusable with more complete chemical description and metal coordination annotation.

Register for the Nov 24 Virtual Office Hour on Exploring CSMs at RCSB.org
Learn how to use RCSB.org features to navigate 3D Computed Structure Models from AlphaFold DB and ModelArchive

Register for the Oct 30 Virtual Office Hour on Structure Summary Pages
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See new feature archiveNews
Publications
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Happy Holidays
Season's greetings from RCSB PDB» 12/19/2025
PDB-101 Focus: Peak Performance
PDB-101 materials explore the structural biology of nutrition.» 12/15/2025
Structural Biology and Nobel Prizes
The Nobel Prize Award ceremony will take place on December 10. Visit PDB-101 to explore connections between Nobel Prizes and more than 50 years of open access to the PDB archive.» 12/07/2025
December 1: World AIDS Day
Watch the documentary Target Zero to learn about the challenge and emotional complexity of the fight to control HIV infection» 11/27/2025
Poster Prize Awarded at The Protein Society
Congratulations to Emily Schaffter (Clark University) for Differential Interactions between Calmodulin and the IQ Motifs of the HECT E3 Ubiquitin Ligases UBE3B and UBE3C» 11/25/2025
Video: Immunology and Cancer
Visit PDB-101 to watch a three-part series exploring the cellular and molecular details of the human immune response to cancer. Now available in English and Spanish.» 11/17/2025
Poster Prizes Awarded at LACA
Congratulations to Miguel Arbeláez (University of São Paulo and National University of Colombia) and Francisco Patrick Ferreira da Silva (Federal University of Ceará, Brazil)» 11/12/2025
PDB-101 Focus: Peak Performance
PDB-101 materials explore the structural biology of nutrition.» 11/11/2025
Education Corner: Cambridge Structural Database
Learn how CCDC is Celebrating 60 Years of Research and Education with Small Molecules» 11/06/2025
Powering a New Era in Structural Biology
Read how integrative modeling transforms how scientists understand molecular machines» 11/04/2025
Molecule of the Month

FOXP3
A master transcriptional regulator of immune tolerance
Read MoreQuarterly News (see archive)
Issue 107 - October 2025
This issue highlights Extended PDB IDs; the Pairwise Alignment Tool, a new animation on Caffeine and Adenosine, and more.
Education Corner: Learn how CCDC is Celebrating 60 Years of Research and Education with Small Molecules.
- Summer 2025 Issue
- Spring 2025 Issue
- Winter 2025 Issue
Annual Reports

2024 Annual Report
Download the 2024 Annual Report (PDF) for an overview of recent activities and the global impact of PDB data and RCSB PDB services.
Annual Report Archive
PDB at a Glance 246,704 Experimental PDB Structures 382 Integrative PDB Structures 78,370 Structures of Human Sequences20,677 Nucleic Acid Containing Structures CSM at a Glance999,251 AlphaFoldDB69,326 ModelArchiveMore Statistics- About
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