Reversing Type 2 Diabetes - Newcastle Magnetic Resonance Centre

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DiRECT

Diabetes REmissions Clinical Trial

Understanding why significant weight loss results in remission of Type 2 diabetes is at the heart of DiRECT.

Once we had shown that type 2 diabetes was a simple condition of too much fat inside liver and pancreas, we needed to move on to discover whether this knowledge could be used for routine treatment of the condition. Professor Roy Taylor collaborated with Professor Mike Lean, University of Glasgow to carry out the Diabetes Remission Clinical Trial (known as DiRECT). It showed:

One third of all people taking part were free of diabetes at 2 years.

Around three quarters of everyone who were in remission at 1 year stayed in remission at 2 years.

The group who embarked on rapid weight loss had fewer serious medical problems in the second year of DiRECT.

At 5 years, those who avoided weight regain continued to be in remission. Even though the whole weight loss group remained over 6kg below their starting weight, the majority did gain some weight. Despite this, the number of serious medical events was halved in the entire weight loss group.

DiRECT results: DiRECT results at 2 years full paper and the online DiRECT appendix are now available.

View details at:

  • the DiRECT study protocol
  • Taylor et al: Who was studied in DiRECT at Diabetologia (2018)
  • Taylor et all: Substantial weight loss can reverse the processes underlying type 2 diabetes at Taylor et al Cell Metabolism 2018‌
  • Al-Mrabeh et al: Hepatic Lipoprotein Export and Remission of Human Type 2 Diabetes after Weight Loss (Cell Metabolism, Dec 2019)

Watch Professor Taylor’s interview: Has DiRECT and Type 2 diabetes remission gone mainstream? (Medscape, 8 March 2019)

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