Successful Verbal Encoding Into Episodic Memory Engages The ...

Trang chủ » Hg Hj H » Successful Verbal Encoding Into Episodic Memory Engages The ...

Có thể bạn quan tâm

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content Dot gov

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation pubmed logo Search: Search Advanced Clipboard User Guide Save Email Send to
  • Clipboard
  • My Bibliography
  • Collections
  • Citation manager
Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

  • My Bibliography
Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons
  • Yes
  • No
Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

HighWire full text link HighWire Free PMC article Full text links

Actions

CiteCollectionsAdd to Collections
  • Create a new collection
  • Add to an existing collection
Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

  • Title & authors
  • Abstract
  • Figures
  • References
  • Publication types
  • MeSH terms
  • Grants and funding
  • LinkOut - more resources
Title & authors Abstract Figures References Publication types MeSH terms Grants and funding LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

The medial temporal lobe (MTL) is essential for episodic memory encoding, as evidenced by memory deficits in patients with MTL damage. However, previous functional neuroimaging studies have either failed to show MTL activation during encoding or they did not differentiate between two MTL related processes: novelty assessment and episodic memory encoding. Furthermore, there is evidence that the MTL can be subdivided into subcomponents serving different memory processes, but the extent of this functional subdivision remains unknown. The aim of the present functional magnetic resonance imaging (fMRI) study was to investigate the role of the MTL in episodic encoding and to determine whether this function might be restricted to anatomical subdivisions of the MTL. Thirteen healthy volunteers performed a word list learning paradigm with free recall after distraction. Functional images acquired during encoding were analyzed separately for each participant by a voxel-wise correlation (Kendall's tau) between the time series of the T2*-signal intensity and the number of subsequently recalled words encoded during each particular scan. Of the 13 participants, 11 showed voxel clusters with statistically significant, positive correlations in the posterior part of the hippocampus. Across participants, an ANOVA on the number of voxels with significant, positive correlations within individually defined volumes of interest confirmed a statistically significant difference in activation for anterior versus posterior regions of the hippocampus. However, no differences between left and right hippocampal activation were revealed. Thus, these findings demonstrate that successful encoding into episodic memory engages neural circuits in the posterior part of the hippocampus.

PubMed Disclaimer

Figures

Fig. 1.

Fig. 1.

A , Depiction of one…

Fig. 1.

A , Depiction of one experimental block. Encoding task with the sequential presentation…
Fig. 1. A, Depiction of one experimental block. Encoding task with the sequential presentation of 15 words per list (duration of each presentation, 500 msec; interstimulus interval, 2500 msec). Each set of MRI scans was acquired during the presentation of five words (15 sec).Distraction task: a 15 sec same/different decision task (duration of each presentation, 150 msec; interstimulus interval, 850 msec). Free recall task for 45 sec. This sequence was performed for a total of 20 blocks in each participant.B, One example of changing hemodynamic response pattern by shifting the assignment between word list and each particular scan by zero, one, or two words, respectively, for 0, 3, or 6 sec. Brain regions showing a significant, positive correlation between their fMRI signals and the number of successfully encoded words. Colored voxels exceeded the statistical threshold (<0.05) and were overlaid on structural images. The left side of each scan is the right side of the brain.
Fig. 2.

Fig. 2.

Brain regions showing a significant,…

Fig. 2.

Brain regions showing a significant, positive correlation between their fMRI signals and the…

Fig. 2. Brain regions showing a significant, positive correlation between their fMRI signals and the number of successfully encoded words. Colored voxels exceeded the statistical threshold (<0.05) and were overlaid on structural images. In thetop row the red bar depicts the approximate location of structural and functional images in the column below. The bottom three rows depict adjacent slices from three subjects (A–C), with one row corresponding to one individual. The left side of each scan is the right side of the brain. The arrows indicate voxels with significant, positive correlations in the posterior part of the hippocampus.
See this image and copyright information in PMC

References

    1. Allen G, Buxton RB, Wong EC, Courchesne E. Attentional activation of the cerebellum independent of motor involvement. Science. 1997;275:1940–1943. - PubMed
    1. Alvarez P, Squire LR. Memory consolidation and the medial temporal lobe: a simple network model. Proc Acad Natl Sci USA. 1994;91:7041–7045. - PMC - PubMed
    1. Amaral DG, Insausti R. Hippocampal formation. In: Paxinos G, editor. The human nervous system. Academic; San Diego: 1990. pp. 711–755.
    1. Baayen RH, Piepenbrock R, van Rijn H. The CELEX lexical database. Linguistic Data Consortium, University of Pennsylvania; Philadelphia: 1993.
    1. Baxendale SA. The role of the hippocampus in recognition memory. Neuropsychologia. 1997;35:591–598. - PubMed
Show all 64 references

Publication types

  • Research Support, Non-U.S. Gov't Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Research Support, U.S. Gov't, P.H.S. Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

MeSH terms

  • Adolescent Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Adult Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Brain Mapping* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Female Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Hippocampus / anatomy & histology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Hippocampus / physiology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Humans Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Magnetic Resonance Imaging Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Male Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Memory / physiology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Temporal Lobe / anatomy & histology Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Temporal Lobe / physiology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search
  • Verbal Learning / physiology* Actions
    • Search in PubMed
    • Search in MeSH
    • Add to Search

Grants and funding

  • MH55714/MH/NIMH NIH HHS/United States

LinkOut - more resources

  • Full Text Sources

    • Europe PubMed Central
    • HighWire
    • PubMed Central

  • Medical

    • ClinicalTrials.gov
    • MedlinePlus Health Information
Full text links [x] HighWire full text link HighWire Free PMC article [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To
  • Clipboard
  • Email
  • Save
  • My Bibliography
  • Collections
  • Citation Manager
[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.

Từ khóa » Hg Hj H