SYD-1, A Presynaptic Protein With PDZ, C2 And RhoGAP ... - PubMed

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Abstract

Axons are defined by the presence of presynaptic specializations at specific locations. We show here that loss-of-function mutations in the C. elegans gene syd-1 cause presynaptic specializations to form in the dendritic processes of GABA-expressing motor neurons during initial differentiation. At a later developmental stage, however, syd-1 is not required for the polarity respecification of a subset of these neurons. The SYD-1 protein contains PDZ, C2 and rho-GTPase activating protein (GAP)-like domains, and is localized to presynaptic terminals in mature neurons. A truncated SYD-1 that lacks the rhoGAP domain interferes with neurite outgrowth and guidance. Our data indicate that syd-1 may be involved in specifying axon identity during initial polarity acquisition.

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• Specifying axon identity with Syd-1. Whited JL, Garrity PA. Whited JL, et al. Nat Neurosci. 2002 Nov;5(11):1107-8. doi: 10.1038/nn1102-1107. Nat Neurosci. 2002. PMID: 12404000 Review. No abstract available.

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