THE EVALUATION OF HEALTHY CHILDREN WITH INCIDENTAL ...

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Hematology, Transfusion and Cell Therapy ISSN: 2531-1379

Hematology, Transfusion and Cell Therapy is a quarterly scientific publication of the Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular (ABHH), Associazione Italo-Brasiliana di Ematologia (AIBE), Eurasian Hematology Oncology Group (EHOG), and Sociedade Brasileira de Oncologia Pediátrica (SOBOPE).Hematology, Transfusion and Cell Therapy publishes original articles, review articles and case reports covering various areas in the field of hematology and hemotherapy. The journal was previously published, until 2016, as Revista Brasileira de Hematologia e Hemoterapia.ISSN print: 2531-1379ISSN online: 2531-1387Published by Elsevier Editora Ltda, Rio de Janeiro, Brazil.

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See more Impact factor 2024 1.6 View more metrics Open Access Option Hide Journal Information Previous article | Next article Vol. 43. Issue S3.Pages S55 (November 2021) Export reference Share Share Twitter Facebook Bluesky Linkedin whatsapp E-mail Print Download PDF More article options Statistics Vol. 43. Issue S3.Pages S55 (November 2021) PP 59 DOI: 10.1016/j.htct.2021.10.1069 Open Access THE EVALUATION OF HEALTHY CHILDREN WITH INCIDENTAL PROLONGATION OF PROTHROMBIN OR ACTIVATED PARTIAL THROMBOPLASTIN TESTS Visits 2588 Download PDF Gökcen MERAL1, Volkan KÖSE1, Vildan ÇULHA1, AYÇA KOCA YOZGATLI1, NAMIK YAŞAR ÖZBEK1, HÜSNİYE NEŞE YARALI21 MINISTRY OF HEALTH ANKARA CITY HOSPITAL, DEPARTMENT OF PEDIATRICS2 ANKARA YILDIRIM BEYAZIT UNIVERSITY FACULTY OF MEDICINE, DEPARTMENT OF PEDIATRICS This item has received 2588 Visits Under a Creative Commons license Article information Statistics Special issue This article is part of special issue: Vol. 43. Issue S3 More info Objective

This cross-sectional study aimed to reveal possible hemostatic disorders in patients referred to the Pediatric Hematology Department due to the prolongation of the prothrombin test (PT) or activated partial thromboplastin test (aPTT).

Methodology

In this study, patients aged 0-18 years without known hematologic disease were referred to investigate the incidental prolonged PT and/or aPTT were evaluated. Mixing studies were performed in patients with continued PT/aPTT prolongation in the control examinations. Coagulation factor activities were analyzed in patients with improvement in mixing study. Antiphospholipid antibodies were studied in patients whose results did not improve with mixing studies.

Results

Coagulopathy was found in 30% of 103 patients. Lupus anticoagulant positivity was found in two patients (1.9%). The most common factor (F) deficiencies were FVII deficiency (10.6%), FXI deficiency (7.8%), FXII deficiency (7.8%), FV deficiency (0.9%), FVIII deficiency (0.9%), fibrinogen and FVII deficiency (0.9%) and von Willebrand factor (vWF) deficiency (0.9%). Coagulopathy was more common in patients with bleeding disorders in their families, and this difference was statistically significant.

Conclusion

In our study, mild factor deficiencies were more common than expected. Coagulation factor deficiencies can be seen in the patients without any finding of physical examination, personal and family histories. There is often no evidence of bleeding in mild factor deficiencies, and the clinical significance is unknown. We recommend using PT and aPTT as screening tests, especially before a major surgical intervention is performed.

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Hematology, Transfusion and Cell Therapy

• Home
• All contents
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• About the journal
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