Triblock Peptide–linker–lipid Molecular Design Improves Potency Of ...

Jump to main content Jump to site search Issue 28, 2015

• Previous Article
• Next Article

From the journal:

Chemical Communications

Triblock peptide–linker–lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors†

Yuting Liu,‡a Yingying Cai,‡a Wei Liu,a Xiao-Han Li,a Elizabeth Rhoadesbc and Elsa C. Y. Yan*a Author affiliations

* Corresponding authors

a Department of Chemistry, Yale University, New Haven, CT 06520, USA E-mail: elsa.yan@yale.edu

b Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06520, USA

c Department of Physics, Yale University, New Haven, CT 06520, USA

Abstract

Two peptide–linker–lipid constructs were designed and prepared which target the parathyroid hormone 1 receptor, a family B G protein-coupled receptor. Both show increased agonist activity in a cell-based assay. The lipid moiety enables the formation of micelle-like nanostructures, which is shown to hinder proteolytic digestion and is expected to reduce renal clearance.

• This article is part of the themed collection: Identification and Optimization of GPCR Ligands in the 21st Century

You have access to this article Please wait while we load your content... Something went wrong. Try again? About Cited by Related Download options Please wait...

Supplementary files

• Supplementary information PDF (926K)

Article information

DOI https://doi.org/10.1039/C5CC00301F Article type Communication Submitted 13 Jan 2015 Accepted 18 Feb 2015 First published 18 Feb 2015

Download Citation

Chem. Commun., 2015,51, 6157-6160 BibTex EndNote MEDLINE ProCite ReferenceManager RefWorks RIS

Permissions

Request permissions

Triblock peptide–linker–lipid molecular design improves potency of peptide ligands targeting family B G protein-coupled receptors

Y. Liu, Y. Cai, W. Liu, X. Li, E. Rhoades and E. C. Y. Yan, Chem. Commun., 2015, 51, 6157 DOI: 10.1039/C5CC00301F

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Tweet Share

Search articles by author

Yuting Liu Yingying Cai Wei Liu Xiao-Han Li Elizabeth Rhoades Elsa C. Y. Yan

Fetching data from CrossRef. This may take some time to load.

Loading related content

Spotlight

Advertisements

This website collects cookies to deliver a better user experience. See how this site uses Cookies. Do not sell my personal data. Este site coleta cookies para oferecer uma melhor experiência ao usuário. Veja como este site usa Cookies. Publishing

Journals

• Current Journals
• Archive Journals
• All Journals

Books

• Browse Books
• Series
• For Authors and Editors
• About

Databases

• Literature Updates
• ChemSpider
• The Merck Index*
• MarinLit

More

• For Members
• For Librarians
• Subscribe
• RSS Feeds
• Blogs
• Chemistry World
• Education in Chemistry
• Open Access
• Historical Collection