Trung C. Nguyen | BCM - Baylor College Of Medicine

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Trung C. Nguyen Trung C. Nguyen Picture Trung C. Nguyen

Associate Professor

Email

[email protected]

Positions

Associate Professor Pediatrics-Critical Care Baylor College of Medicine Houston, Texas United States Core Faculty Center for Translational Research on Inflammatory Diseases (CTRID) Michael E. DeBakey VA Medical Center Baylor College of Medicine Houston, Texas United States

Addresses

Texas Children's Hospital - Legacy Tower (Clinic) 6651 Main Street, Mail Stop: E1420 Houston, TX 77030 United States Phone: (832) 826-6230

Education

Fellowship at University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania United States National Research Service Award Fellowship Training (T32) (NICHD T32 HD40686) in Pediatric Neurointensive Care and Resuscitation Research, 2001-2003 Residency at New York Hospital - Cornell Medical Center New York, New York United States Pediatric Chief Residency, 1998-99 Fellowship at University of Pittsburgh School of Medicine Pittsburgh, Pennsylvania United States Pediatric Critical Care Medicine Fellowship, 1999-2002 Residency at New York Hospital - Cornell Medical Center New York, New York United States Pediatric Residency, 1996-98 Residency at New York Hospital - Cornell Medical Center New York, New York United States Pediatric Internship, 1995-96 MD from University of Virginia School of Medicine Charlottesville, Virginia United States 1995 BA from Cornell University Ithaca, New York United States Biology, 1991

Certifications

Pediatric Critical Care Medicine American Board of Pediatrics

Honors & Awards

Society of Critical Care Medicine Presidential Citation 2015, 2016, 2019, 2020 Society of Critical Care Medicine, Hematology Specialty Award 2013 Fullbright & Jaworski L.L.P. Faculty Excellence Award for Teaching and Evaluation 2011 Baylor College of Medicine Society of Critical Care Medicine Research Citation, 2002, 2004, 2008 Society of Critical Care Medicine Educational Scholarship Award 2003 Society of Critical Care Medicine Annual Scientific Award 2001 Outstanding Medical Teacher Award , Cornell University Medical Class of 1999 Distinguished Alumni Award 2020-2021 The University of Pittsburgh Department of Critical Care Medicine Study Section, Invited Reviewer, March 2020, October 2017 March 2020, October 2017 National Heart Lung Blood Institute Research Mentorship Award Associate Professor Level Department of Pediatrics, Baylor College of Medicine, 2017 Senior Investigator Abstract Award, 2018 9th Congress of the World Federation of Pediatric Intensive & Critical Care Societies, 2018 #1 Abstract Award at the Michael DeBakey Veterans Affairs Medical Center Research Competition, 2018 Michael DeBakey Veterans Affairs Medical Center Research Competition, 2018 Chartered Member - Mentored Clinical and Basic Science Review Committee NIH NHLBI (06/2022 - 06/2026)

Websites

VIICTR Publications List Center for Translational Research on Inflammatory Diseases (CTRID)

Professional Development

Plasma Therapies and Beyond Conference (Presenter, 2015) Sponsor: Society of Critical Care 44th Annual Congress Pediatric Multiple Organ Dysfunction Syndrome Workshop Conference (Presenter, 2015) Sponsor: National Institute of Health – Eunice Kennedy Shriver National Institute of Child Health and Human Development Sepsis Phenotypes: Targets for Blood Purification Conference (Presenter, 2014) Sponsor: Acute Dialysis Quality Initiative XIV Consensus Conference Multiple Organ Failure Phenotyping Conference (Presenter, 2014) Sponsor: ” Noon Grand Round, Section of Critical Care, Department of Pediatrics, Texas Children’s Hospital/Baylor College of Medicine Red, White and Purple: The Colors of Sepsis-induced Multiple Organ Failure Conference (Presenter, 2014) Sponsor: Pediatric Grand Round at MD Anderson Cancer Center The Evolution of TAMOF Research Seminar (Presenter, 2020) Sponsor: The University of Pittsburgh Department of Critical Care Medicine Grand Round Therapeutic Plasma Exchange in Critical Illness Conference (Presenter, 2020) Sponsor: World Federation of Pediatric Intensive & Critical Care Societies Congress Sepsis-Induced Multiple Organ Dysfunction Syndromes Conference (Presenter, 2020) Sponsor: Pediatric Current Concepts, Society of Critical Care Medicine 49th Annual Congress Thrombocytopenia-Associated Multiple Organ Failure Conference (Presenter, 2019) Sponsor: Pediatric Critical Care Summit of The Americas, 15th Latin American Congress of Pediatric Intensive Care & 26th Pediatric Critical Care Colloquium U.S.A.

Selected Publications

• • Nguyen TC, Gushiken F, Correa JI, et al. "A recombinant fragment of von Willebrand factor reduces fibrin-rich microthrombi formation in mice with endotoxemia.." Thrombosis Research. 2015 Mar;135((5)):1025-1030. Pubmed PMID: 25769494
• Brubaker LS, Saini A, Nguyen TC, Martinez-Vargas M, Lam FW, Yao Q, Loor MM, Rosengart TK, Cruz MA. "Aberrant Fibrin Clot Structure Visualized Ex Vivo in Critically Ill Patients With Severe Acute Respiratory Syndrome Coronavirus 2 Infection.." Crit Care Med. 2022 Feb 15;50(6):E557–E568. Pubmed PMID: 35170535
• Nguyen TC, Liu A, Liu L, Ball C, Choi H, May WS, Aboulfatova K, Bergeron AL, Dong JF "Acquired ADAMTS-13 deficiency in pediatric patients with severe sepsis.." Haematologica. 2007 Jan;92(1):121-4. Pubmed PMID: 17229645
• Davis AL, Carcillo JA, Aneja RK, Deymann AJ, Lin JC, Nguyen TC, Okhuysen-Cawley RS, Relvas MS, Rozenfeld RA, Skippen PW, et al "American College of Critical Care Medicine Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock." Crit Care Med. 2017 Jun;45(6):1061-1093. Pubmed PMID: 28509730

• • Weiss SL, Peters MJ, Alhazzani W, … Nguyen TC, et al "Executive summary: surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.." Intensive Care Med. 2020 Feb;46(Suppl 1):1-9. Pubmed PMID: 32030528
• • Chinn IK, Eckstein OS, Peckham-Gregory EC, Goldberg BR, Forbes LR, Nicholas SK, Mace EM, Vogel TP, Abhyankar HA, Diaz MI, Heslop HE, Krance RA, Martinez CA, Nguyen TC, Bashir DA, Goldman JR et al. "Genetic and Mechanistic Diversity in Pediatric Hemophagocytic Lymphohistiocytosis." Blood. 2018 Jul;132((1)):89-100. Pubmed PMID: 6034641
• Goldman J, Desai MS, McClain KL, Tcharmtchi MH, Kennedy CE, Thompson K, Lam F, Bashir DA, Chinn IK, Goldberg BR, Allen CE, Nguyen TC. "Hepatobiliary Dysfunction and Disseminated Intravascular Coagulation Increase Risk of Mortality in Pediatric Hemophagocytic Lymphohistiocytosis." Pediatr Crit Care Med. 2019 Oct;19((10)):e522-e530. Pubmed PMID: 30113519
• Lin H, Scull BP, Goldberg BR,…Nguyen TC, et al. "IFN-gamma signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS.." Blood Adv. 2021;5(17):3457-3467. Pubmed PMID: 34461635
• Nguyen TC, Han YY, Kiss JE, Hall MW, Hassett AC, Jaffe R, Orr RA, Janosky J, Carcillo JA "Intensive plasma exchange increases a disintegrin and metalloprotease with thrombospondin motifs-13 activity and reverses organ dysfunction in children with thrombocytopenia-associated multiple organ failure.." Crit. Care Med.. 2008 Oct;36(10):2878-87. Pubmed PMID: 18828196
• • Valladolid C, Martinez-Vargas M, Sekhar N, Lam F, Brown C, Palzkill T, Tischer A, Auton M, Vijayan KV, Rumbaut RE, Nguyen TC, Cruz MA "Modulating the Rate of Fibrin Formation and Clot Structure Attenuates Microvascular Thrombosis in Systemic Inflammation." Blood Adv. 2020 Apr 14;4((7)):1340-1349. Pubmed PMID: 32259201
• • Weiss SL, Peters MJ, Alhazzani W, …Nguyen TC, et al "Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children.." Intensive Care Med. 2020 Feb 7;46(Suppl 1):10-67. Pubmed PMID: 32030529
• • Fortenberry JD, Nguyen T, Grunwell JR, Aneja RK, Wheeler D, Hall M, Fleming G, Tarrago R, Buttram S, Dalton H, et al "Therapeutic Plasma Exchange in Children With Thrombocytopenia-Associated Multiple Organ Failure: The Thrombocytopenia-Associated Multiple Organ Failure Network Prospective Experience." Crit Care Med. 2019 Mar;47((3)):e173-e181. Pubmed PMID: 30531184
• "Secretion of von Willebrand Factor and Suppression of ADAMTS-13 Activity by Markedly High Concentration of Ferritin." Clin Appl Thromb Hemost. 2021; Pubmed PMID: 33539188

Hide 9 publications Show 9 more selected publications

Memberships

American Academy of Pediatrics Society of Critical Care Medicine Baylor College of Medicine Affiliated Hospital Member of Steering Committee Pediatric Section Executive Committee of the Society of Critical Care Medicine Members-At-Large American College of Critical Care Medicine: Clinical Practice Parameters for Hemodynamic Support of Pediatric and Neonatal Septic Shock Society of Critical Medicine and European Society of Intensive Care Medicine Invited Committee Member

Funding

Microvascular Thrombosis in Systemic Inflammation - #2R01GM112806 ( 09/05/2013 - 06/30/2023 ) Grant funding from NIH NIGMS Multi-Principal Investigator R01 Role: Principal Investigator ADAMTS-13 and Inflammation - #K08 GM83212 ( 05/01/2008 - 05/31/2014 ) Grant funding from NIH NIGMS Principal Investigator No Cost Extension 5/31/2014 Collaborative Pediatric Critical Care Research Network - #RL1HD107780 ( 04/01/2021 - 03/31/2026 ) Grant funding from NIH NICHD The goal of this study is to implement CPCCRN organization, mount strategies for development of young clinician scientists, and conduct a large-scale multicenter study of personalized, targeted immune modulation in children with sepsis-induced multiple organ dysfunction syndrome. Novel Treatment for DIC - #R41 HL135942 ( 08/20/2018 - 07/30/2020 ) Grant funding from NIH NIGMS Small Business Technology Transfer Grant Role: Co-Investigator 8/20/2018-7/31/2019, No Cost Extension 7/30/2020 Therapeutic and Metabolic Responses of Citrulline vs. Arginine Supplementation - #R01 GM108940 ( 07/10/2020 - 06/30/2024 ) Grant funding from NIH NIGMS The goal of this study is to investigate the metabolic mechanism behind arginine depletion and devise strategies to restore arginine availability in sepsis and septic shock. Hide 1 funding Show 1 more selected funding

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