TSH Protein (>50% Pure) (DAGA-225) - Creative Diagnostics

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TSH protein (>95% pure)

Thyroid stimulating hormone, purified from human pituitary glands

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Target TSH Nature Native Tag/Conjugate N/A Bio-activity ≥ 6.2 IU/mg Alternative Names Thyroid stimulating hormone; TSH Purity > 95 % as determined by SDS-PAGE Format Lyophilized Buffer 10 mM Sodium Phosphate, 150 mM Sodium Chloride, 1 mg/ml BSA, pH 7.4 Preservative 0.1% Sodium Azide (optional) Storage Store at 2°C to 8°C short term (up to 2 weeks) or frozen below -20°C Introduction Thyroid-stimulating hormone (also known as TSH or thyrotropin) is a peptide hormone synthesized and secreted by thyrotrope cells in the anterior pituitary gland, which regulates the endocrine function of the thyroid gland. Keywords Thyroid stimulating hormone; TSH Citations Have you cited DAGA-225 in a publication? Let us know and earn a reward for your research.

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Correlation between TSH levels and quality of life among subjects with well-controlled primary hypothyroidism

ENDOCRINE

Authors: Moron-Diaz, Marta; Saavedra, Pedro; Alberiche-Ruano, Maria P.; Rodriguez-Perez, Carlos A.; Lopez-Plasencia, Yaiza; Marrero-Arencibia, Dunia; Gonzalez-Lleo, Ana M.; Boronat, Mauro

Abstract

Purpose It has been suggested that increasing levothyroxine dose to lower TSH levels within the normal laboratory range might be a therapeutic option for patients with apparently well-controlled primary hypothyroidism who are dissatisfied with their treatment and complain of physical or psychological symptoms. This study assessed whether there is a relationship between TSH levels and health-related quality of life (HRQoL) among subjects with adequately treated hypothyroidism. Methods HRQoL was measured with the specific thyroid disease ThyPRO-39 questionnaire in 218 consecutive patients with primary hypothyroidism of any cause attending an Endocrinology Department in a single center. Patients had TSH values within the normal laboratory range on a blood test performed not before than 6 weeks prior to study participation, but they were not aware of their lab results. The association between TSH values and the different ThyPRO-39 scales was analyzed by means of multiple regression models, both linear and additive, in which, in addition to TSH, a wide set of clinical and sociodemographic variables potentially related to HRQoL were also considered. Results TSH levels and the use of anxiolytic and antidepressant drugs were the only variables that showed a positive linear correlation with the ThyPRO-39 composite scale in the multivariate regression analysis, indicating greater impairment in HRQoL with increasing TSH values. TSH was also independently correlated to scores of scales dealing on tiredness and emotional susceptibility. Conclusions In patients with primary hypothyroidism, higher TSH values, even within the normal reference range, are associated with greater deterioration of HRQoL.

The Level of Serum C-Reactive Protein and Neutrophil Lymphocyte Ratio According to Thyroid Function Status

CLINICAL AND EXPERIMENTAL HEALTH SCIENCES

Authors: Kar, Fatih; Kiraz, Zeynep Kusku; Kocaturk, Evin; Uslu, Sema

Abstract

Objective: We aimed to investigate neutrophil lymphocyte ratio (NLR), leukocyte count (WBC), mean platelet volume (MPV) and C-reactive protein levels (CRP) as inflammatory markers according to thyroid function status in hypo-hyperthyroidism patients. Methods: Data of patients (n=454, age>18) who applied to the Eskisehir Osmangazi University Hospital between March 2018 and December 2018 were evaluated retrospectively. There were 79 patients in hyperthyroidism group (TSH4.2 mu IU/ml, group III). Results: Serum TSH, fT4, fT3, anti-TG and anti-TPO levels were found statistically different between groups (p