Use Of Combined Gn-RH Agonist And HGH Therapy For Better Attining ...

Clipboard, Search History, and several other advanced features are temporarily unavailable. Skip to main page content

The .gov means it’s official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation Search: Search Advanced Clipboard Save Email Send to

• Clipboard
• My Bibliography
• Collections
• Citation manager

Display options Display options Format Abstract PubMed PMID

Save citation to file

Format: Summary (text) PubMed PMID Abstract (text) CSV Create file Cancel

Email citation

Email address has not been verified. Go to My NCBI account settings to confirm your email and then refresh this page. To: Subject: Body: Format: Summary Summary (text) Abstract Abstract (text) MeSH and other data Send email Cancel

Add to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an error Please try again Add Cancel

Add to My Bibliography

• My Bibliography

Unable to load your delegates due to an error Please try again Add Cancel

Your saved search

Name of saved search: Search terms: Test search terms Would you like email updates of new search results? Saved Search Alert Radio Buttons

• Yes
• No

Email: (change) Frequency: Monthly Weekly Daily Which day? The first Sunday The first Monday The first Tuesday The first Wednesday The first Thursday The first Friday The first Saturday The first day The first weekday Which day? Sunday Monday Tuesday Wednesday Thursday Friday Saturday Report format: Summary Summary (text) Abstract Abstract (text) PubMed Send at most: 1 item 5 items 10 items 20 items 50 items 100 items 200 items Send even when there aren't any new results Optional text in email: Save Cancel

Create a file for external citation management software

Create file Cancel

Your RSS Feed

Name of RSS Feed: Number of items displayed: 5 10 15 20 50 100 Create RSS Cancel RSS Link Copy

Full text links

S. Karger AG, Basel, Switzerland Full text links

Actions

CiteCollectionsAdd to Collections

• Create a new collection
• Add to an existing collection

Name your collection: Name must be less than 100 characters Choose a collection: Unable to load your collection due to an errorPlease try again Add Cancel PermalinkPermalinkCopyDisplay options Display options Format AbstractPubMedPMID

Page navigation

• Title & authors
• Abstract
• Publication types
• MeSH terms
• Substances
• LinkOut - more resources

Title & authors Abstract Publication types MeSH terms Substances LinkOut - more resources Full text links CiteDisplay options Display options Format AbstractPubMedPMID

Abstract

We studied 30 girls (age 6.36 +/- 1.21 years, range 4.6-8.8) affected by idiopathic precocious puberty with significant reduction of height velocity (below the 25th centile) at the end of 1 year of Gn-RHa (triptorelin intramuscular depot) treatment, to evaluate GH-IGF-I axis activity and the effects of combined Gn-RHa plus hGH therapy. After 12 months, 15 patients continued Gn-RHa and started hGH therapy for 12 months, while 15 continued treatment with Gn-RHa alone (control group). We evaluated height velocity, bone age, urinary GH, serum IGF-I and IGFBP-3 levels throughout the study; plasma GHBP levels were determined only in the first 12 months of Gn-RHa treatment. Height velocity decreased significantly during Gn-RHa treatment; it increased significantly and became higher than the control group after 12 months of Gn-RHa plus hGH treatment. During Gn-RHa therapy alone, bone age progressed less than chronological age, while in the 12 months of Gn-RHa plus hGH treatment there was a slight nonsignificant increase in bone age progression in comparison to controls. Serum IGF-I and IGFBP-3 levels decreased significantly at 12 months of Gn-RHa therapy and increased significantly after Gn-RHa plus hGH treatment. Urinary GH levels showed the same behavior. Plasma GH binding to peak II-BP, slightly lower than the prepubertal normal range before treatment, significantly increased after 12 months of Gn-RHa treatment. Therefore, in these girls, during Gn-RHa treatment alone, we have a reduction in GH-IGF-I axis activity. During Gn-RHa plus hGH therapy there was a significant increase in height velocity, in urinary GH levels, in serum IGF-I and IGFBP-3 levels. Bone age did not seem to advance faster than chronological age and this may imply a better prediction in adult height. In our opinion, only in a small percentage of patients affected by precocious puberty (with a very low predicted adult height or an important reduction of growth velocity during Gn-RHa treatment) may an association with hGH therapy be useful.

PubMed Disclaimer

Publication types

• Clinical Trial Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Multicenter Study Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Randomized Controlled Trial Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

MeSH terms

• Body Height / drug effects Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Child Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Child, Preschool Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Delayed-Action Preparations Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Drug Therapy, Combination Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Estradiol / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Female Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Follicle Stimulating Hormone / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Gonadotropin-Releasing Hormone / agonists* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Growth Disorders / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Growth Disorders / drug therapy* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Growth Hormone / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Growth Hormone / therapeutic use* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Humans Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Injections, Intramuscular Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Insulin-Like Growth Factor Binding Protein 3 / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Insulin-Like Growth Factor I / metabolism Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Luteinizing Hormone / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Luteolytic Agents / therapeutic use* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Puberty, Precocious / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Puberty, Precocious / drug therapy* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Recombinant Proteins / blood Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Recombinant Proteins / therapeutic use Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Triptorelin Pamoate / therapeutic use* Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

Substances

• Delayed-Action Preparations Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Insulin-Like Growth Factor Binding Protein 3 Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Luteolytic Agents Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Recombinant Proteins Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Triptorelin Pamoate Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Gonadotropin-Releasing Hormone Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Estradiol Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Insulin-Like Growth Factor I Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Luteinizing Hormone Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Follicle Stimulating Hormone Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search
• Growth Hormone Actions
  • Search in PubMed
  • Search in MeSH
  • Add to Search

LinkOut - more resources

• Full Text Sources

  • S. Karger AG, Basel, Switzerland

• Medical

  • MedlinePlus Health Information

• Miscellaneous

  • NCI CPTAC Assay Portal

Full text links [x] S. Karger AG, Basel, Switzerland [x] Cite Copy Download .nbib .nbib Format: AMA APA MLA NLM Send To

• Clipboard
• Email
• Save
• My Bibliography
• Collections
• Citation Manager

[x]

NCBI Literature Resources

MeSH PMC Bookshelf Disclaimer

The PubMed wordmark and PubMed logo are registered trademarks of the U.S. Department of Health and Human Services (HHS). Unauthorized use of these marks is strictly prohibited.