Valium Vs. Xanax: Differences, Similarities, And Effects
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Medically reviewed by Dena Westphalen, PharmD — Written by Claire Sissons — Updated on February 17, 2023- Similarities and differences
- How they work
- Side effects
- Withdrawal
- Dangers
- Drug interactions
- Who should avoid Valium or Xanax?
- Takeaway
Valium and Xanax are both benzodiazepines doctors prescribe to treat anxiety. However, there are key differences in side effects and drug interactions.
Valium and Xanax are brand names for two types of medication for anxiety. The generic name for Valium is diazepam. The generic name for Xanax is alprazolam.
Many anxiety symptoms result, to some extent, from a chemical imbalance in the brain. Medication can help change this imbalance.
Sedatives slow down certain functions in the body. This can help a person sleep or make them feel calmer.
The best choice of medication and the dosage and duration of treatment will be different for each individual.
Similarities and differences
Share on PinterestValium and Xanax are different medications. A doctor should help a person decide which is most suitable.
People can take either medication as tablets or liquid, but adults usually only receive a prescription for pills.
An individual tends to take Valium or Xanax one to four times per day, but the dosage will depend on the person’s needs and on the medication, due to the differing lengths of action.
The following are some key facts about each:
| Xanax | Valium |
| used to treat severe anxiety and panic disorders | used to treat less severe anxiety disorders, alcohol and drug withdrawal, muscle spasms, and seizures |
| intermediate onset (15–30 minutes) | rapid onset (within 15 minutes) |
| can cause dependency | can cause dependency |
| causes withdrawal symptoms | causes withdrawal symptoms |
| withdrawal does not last longer if a person takes the drug for a longer period | withdrawal does not last longer if a person takes the drug for a longer period |
How they work
Both medications work with a chemical in the brain called gamma-Aminobutyric acid (GABA).
GABA reduces activity in parts of the brain that control memory, emotions, logical thought, and functions such as breathing.
Valium and Xanax increase the effects of GABA. This makes the muscles relax, reduces anxiety, and causes drowsiness.
Side effects
Valium and Xanax have similar side effects. Seek medical advice if any of these symptoms are severe or last for a long time.
FDA black box warning
- Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death.
- Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate.
- Limit dosages and durations to the minimum required.
- Follow patients for signs and symptoms of respiratory depression and sedation.
Common side effects of these drugs include:
| Side effect | Valium | Xanax |
| drowsiness | X | X |
| dizziness | X | X |
| fatigue | X | X |
| dry mouth | X | X |
| nausea | X | X |
| appetite changes | X | X |
| constipation | X | X |
| headache | X | |
| irritability | X | |
| difficulty concentrating | X | |
| weight changes | X | |
| weakness | X | |
| diarrhea | X | |
| restlessness | X | |
| blurred vision | X | |
| sex drive changes | X | X |
| difficulty urinating | X | X |
| joint pain | X | |
| increased salivation | X |
Some side effects can be serious. A person should seek urgent medical attention if they experience any of the following:
| Side effect | Valium | Xanax |
| seizures | X | X |
| fever | X | |
| shuffling walk | X | |
| lasting tremor | X | |
| difficulty breathing | X | X |
| difficulty swallowing | X | |
| serious skin rash | X | X |
| yellow skin or eyes | X | X |
| irregular heartbeat | X | |
| hallucinations | X | |
| depression | X | |
| memory problems | X | |
| confusion | X | |
| speech problems | X | |
| thoughts of suicide | X | |
| balance problems | X | |
| lightheadedness | X | |
| talkativeness | X | |
| behavior or mood changes | X |
These are partial lists of side effects. Effects may vary between individuals. People should talk to their doctor about side effects before using these drugs.
If anyone experiences these adverse effects, they should contact 911 or the nearest emergency line in their area.
Withdrawal
A person who has taken Valium or Xanax regularly for a long time may experience withdrawal if they stop taking the medication. These symptoms may be physical or mental.
Withdrawal symptoms are similar for both, but Xanax may cause more symptoms than Valium.
Some examples of these withdrawal symptoms include:
- stomach cramps
- increased feeling of anxiety
- headaches
- dizziness
- problems sleeping
A person should not stop either medication without talking with their doctor and establishing a plan. This is very important due to the potential for withdrawal symptoms.
It is possible for withdrawal symptoms to last for weeks or months. Support from friends, family, a group, or an organization can help a person coping with these effects. A doctor may be able to prescribe medication to help with withdrawal symptoms.
Dangers
If a person does not have certain underlying health conditions, Valium and Xanax are safe to take as long as a person follows a doctor’s instructions.
Both medications can cause dependency because they trigger significant changes in the brain, and withdrawal can be difficult.
For this reason, doctors tend to recommend Valium and Xanax for short-term use.
Drug interactions
People may not be able to take certain medications alongside Valium or Xanax. A person should talk with their doctor or pharmacist and review current medications to decide what they can or cannot take.
The list below covers some of the drugs that may interact with Valium or Xanax, but there may be more. People should talk with their doctor about all possible interactions that may occur.
Valium
Treatments that can interact with Valium include:
- opioids
- alcohol
- antacids
- cimetidine, ketoconazole, fluvoxamine, fluoxetine, and omeprazole, which inhibit certain hepatic enzymes, such as cytochrome P450 3A and 2C19
- phenytoin
- centrally acting agents
Examples of centrally acting agents include: phenothiazines, antipsychotics, anxiolytics and sedatives, hypnotics, anticonvulsants, narcotic analgesics, anesthetics, sedative antihistamines, narcotics, barbiturates, MAO inhibitors, and other antidepressants.
This is a partial list of interactions. Before starting treatment the individual should talk with their doctor or pharmacist about all medications, herbs, and supplements they are taking to ensure they are safe.
Xanax
Drugs and drug types that may interact with Xanax include:
- opioids
- alcohol
- other central nervous system (CNS) depressants
- digoxin
- imipramine
- desipramine
- drugs that inhibit CYP450 3A (examples include fluoxetine, propoxyphene and oral contraceptives)
A doctor may advise a person with a prescription for Valium or Xanax to stop taking other medications, or change the dosage of that person’s medications. The doctor may also monitor the person regularly for side effects.
This is a partial list of interactions. Before starting treatment the individual should talk with their doctor or pharmacist about all medications, herbs, and supplements they are taking to ensure they are safe.
»MORE:Get a refill for your medication in as little as 15 minutes with Optum Now Online Care.Optum Now is operated by RVO Health. By clicking on this link, we may receive a commission. Learn more.
Who should avoid Valium or Xanax?
These medications are not suitable for everyone. A doctor will ask about existing conditions before prescribing Valium or Xanax.
People with the following medical conditions usually cannot take Valium or Xanax:
- breathing problems or lung disease
- severe kidney or liver disease
- sleep apnea
- muscle weakness
- previous or current drug or alcohol addiction or misuse
- depression
- glaucoma
Children generally cannot take Valium or Xanax. Older adults can, but they usually receive a reduced dosage. There is very little data showing the use of either Valium or Xanax in children.
People should speak to their doctor if they are pregnant, are planning to become pregnant, or might become pregnant. There is no data in humans to show that either of these medications is safe or harmful during pregnancy or breastfeeding.
Both drugs can cause drowsiness. A person should usually not drive or operate machinery while taking either medication.
Takeaway
Valium and Xanax are different, though they can treat similar issues. A doctor considers a range of factors before recommending either.
- Mental Health
- Anxiety / Stress
- Pharmacy / Pharmacist
How we reviewed this article:
SourcesMedical News Today has strict sourcing guidelines and relies on peer-reviewed studies, academic research institutions, and medical journals and associations. We only use quality, credible sources to ensure content accuracy and integrity. You can learn more about how we ensure our content is accurate and current by reading our editorial policy.- Alprazolam. (2017).https://medlineplus.gov/druginfo/meds/a684001.html
- Anxiety. (n.d.)https://www.mhanational.org/conditions/anxiety
- Anxiety disorders. (n.d.). http://www.mentalhealthamerica.net/conditions/anxiety-disorders
- Comparison of benzodiazepines. (n.d.).http://www.vhpharmsci.com/vhformulary/tools/benzodiazepines-comparison.htm
- Diazepam. (2019). https://medlineplus.gov/druginfo/meds/a682047.html
- FDA requiring Boxed Warning updated to improve safe use of benzodiazepine drug class. (2020).https://www.fda.gov/drugs/drug-safety-and-availability/fda-requiring-boxed-warning-updated-improve-safe-use-benzodiazepine-drug-class
- Lautieri, A. (2020). Xanax withdrawal - Symptoms, duration, dangers, and treatment.https://americanaddictioncenters.org/withdrawal-timelines-treatments/xanax
- Medication. (n.d.). http://www.mentalhealthamerica.net/medication
- Sleeping pills and minor tranquillisers. (2016).https://www.mind.org.uk/information-support/drugs-and-treatments/sleeping-pills-and-minor-tranquillisers/about-benzodiazepines/#.W9cQm3r7SRs
- Xanax — Alprazolam tablet. (2020).https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=388e249d-b9b6-44c3-9f8f-880eced0239f
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Medically reviewed by Dena Westphalen, PharmD — Written by Claire Sissons — Updated on February 17, 2023Latest news
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